Advances in Male Contraception

Page, Stephanie T.; Amory, John K.; Bremner, William J.

doi:10.1210/er.2007-0041

Cited by 711 publications

(166 citation statements)

References 363 publications

(175 reference statements)

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“…7 Furthermore, although acute administration of kisspeptin seems to increase LH, FSH and testosterone secretion, chronic administration lowers serum LH levels in monkeys. 8,9 Manipulation of the kisspeptin-GPR54 pathway represents another potential target for future male contraceptive therapy. 8 Complex interplay between testosterone, FSH and other factors is important for normal spermatogenesis.…”

Section: Review Of Hypothalamic-pituitarygonadal Axis and Spermatogenmentioning

confidence: 99%

“…8,9 Manipulation of the kisspeptin-GPR54 pathway represents another potential target for future male contraceptive therapy. 8 Complex interplay between testosterone, FSH and other factors is important for normal spermatogenesis. Sertoli cells are part of the seminiferous tubules that are activated by FSH and function to provide the optimal environment for the developing sperm cells throughout spermatogenesis.…”

Section: Review Of Hypothalamic-pituitarygonadal Axis and Spermatogenmentioning

confidence: 99%

“…However, the role of inhibin in FSH suppression and spermatogenesis is unclear, as low levels of inhibin are still present with LH-receptor mutations and chronic FSH administration. 8,10,11 Progesterone receptors are seen in the hypothalamus, pituitary and testis. It appears that progesterone affects gonadotropins via the hypothalamicpituitary-testis axis, however, they may function directly on the testis as well.…”

Section: Review Of Hypothalamic-pituitarygonadal Axis and Spermatogenmentioning

confidence: 99%

“…8,[36][37][38][39][40][41][42][43] The purpose of this review was to summarize the published data regarding hormone-based male contraceptive treatment options.…”

Section: Hormonal Treatmentmentioning

confidence: 99%

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Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti

Honig

2010

Int J Impot Res

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Traditionally, male contraception has consisted of either barrier methods, such as condoms, or vasectomy. However, in recent years, we have made great strides in the basic science and clinical medicine to better understand the feedback mechanisms and physiology of the male reproductive system. These advances have enabled the development of several nonsurgical, hormonal, reversible, well-tolerated alternatives for male contraception. Men are more likely now than ever to participate in the choice of contraceptive techniques. This review will discuss the current status and recent developments in nonsurgical hormonal male contraception, a field that has been historically limited by social, financial and physiological challenges.

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Section: Review Of Hypothalamic-pituitarygonadal Axis and Spermatogenmentioning

confidence: 99%

Section: Review Of Hypothalamic-pituitarygonadal Axis and Spermatogenmentioning

confidence: 99%

Section: Review Of Hypothalamic-pituitarygonadal Axis and Spermatogenmentioning

confidence: 99%

“…8,[36][37][38][39][40][41][42][43] The purpose of this review was to summarize the published data regarding hormone-based male contraceptive treatment options.…”

Section: Hormonal Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti

Honig

2010

Int J Impot Res

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“…Exogenously administered testosterone maintains sexual function and other androgenic effects on other reproductive and non-reproductive target organs without supporting spermatogenesis. [1][2][3][4][5][6][7] Studies from our group and others showed that low intratesticular testosterone levels decrease spermatogonia proliferation, accelerate apoptosis, and result in defects in spermiation and sequestration of mature spermatozoa by Sertoli cells. [8][9][10][11][12][13][14] Two landmark contraceptive efficacy studies of testosterone induced azoospermia and severe oligozoospermia conducted by WHO (World Health Organization) in 1990s showed conclusively that when spermatogenesis is severely suppressed by exogenous intramuscular administration of testosterone in healthy men, contraceptive efficacy comparable to hormonal contraceptive methods for women can be achieved.…”

Section: Introductionmentioning

confidence: 99%

Does ethnicity matter in male hormonal contraceptive efficacy?

Ilani¹,

Liu²,

Swerdloff³

et al. 2011

Asian J Androl

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The development of male hormonal contraception has progressed significantly during the last three decades. The ultimate goal is to produce an effective, safe and reversible male method of contraception that are within reach of and can be used by all men globally. This review aims to outline the recent developments in male hormonal contraception with special emphasis on how ethnicity influences acceptability, extent of sperm suppression, and rate of recovery of spermatogenesis. Baseline differences in testicular histomorphology and testosterone metabolism between East Asian and Caucasian men have been reported, but whether this contributes significantly to varying degrees of sperm suppression in response to exogenous testosterone therapy is less known. Testosterone alone male hormonal contraceptive regimens are effective and applicable for East Asian men, and less so for Caucasians. Combinations of progestins with androgens are sufficient to optimize effectiveness of suppression and applicability to all ethnicities. New compounds such as steroidal or non-steroidal selective androgen receptor modulators with dual androgenic and progestational activities are potential compounds for further development as male hormonal contraceptive methods. At the present time, combined androgen and progestin contraceptive regimens appear to be effective, safe, reversible and convenient to use for all men with ethnic, cultural and environmental differences. Further refinements on the hormonal agent, methods of delivery, and dose optimization of the androgen relative to the progestin are necessary. This goal mandates further investment and large clinical trials in multiethnic populations to better define safety and efficacy.

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Vasectomy occlusion techniques for male sterilization

Cook

Vliet

Lopez

et al. 2007

Cochrane Database of Systematic Reviews

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For vas occlusion with clips or vasectomy with vas irrigation, no conclusions can be made as those studies were of low quality and underpowered. Fascial interposition reduced vasectomy failure. An intra-vas device was less effective in reducing sperm count than was no-scalpel vasectomy. Randomized controlled trials examining other vasectomy techniques were not available. More and better quality research is needed to examine vasectomy techniques.

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Advances in Male Contraception

Cited by 711 publications

References 363 publications

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Does ethnicity matter in male hormonal contraceptive efficacy?

Vasectomy occlusion techniques for male sterilization

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