Advances in microneedles research based on promoting hair regrowth

Zhou, Yanjun; Jia, Luan; Zhou, Di; Chen, Gang; Fu, Qiang; Li, Ning

doi:10.1016/j.jconrel.2022.12.040

Cited by 31 publications

(18 citation statements)

References 97 publications

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“…The results of the one‐way repeated measures ANOVA for N 1– N 7 were significant, revealing significant differences in all pairwise comparisons, indicating that scalp repair serum microneedle combined therapy had a positive therapeutic effect on moderate to severe androgenetic alopecia. Compared with previous studies, 11,13,17,19 the combined treatment interval in this study was 2 weeks. This interval showcased outstanding efficacy, suggesting that the hair restoration serum significantly improved treatment efficiency and enhanced patient compliance.…”

Section: Discussionmentioning

confidence: 91%

Observing the clinical efficacy of combined serum microneedle therapy for moderate to severe androgenetic alopecia in scalp repair

Zhang,

Jia,

et al. 2024

Skin Research and Technology

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ObjectiveIn this study, the safety and efficacy of scalp repair serum microneedles combined with oral drug administration and topical medication were investigated for the treatment of moderate to severe androgenetic alopecia.MethodsTwenty patients, consisting of 4 males and 16 females, who sought treatment for moderate to severe androgenetic alopecia at our hair medicine research center alopecia specialty clinic between August and December 2022 were randomly selected for the study. Male patients underwent oral administration of finasteride topical application of 5% minoxidil, and biweekly scalp repair serum microneedle therapy. Female patients were administered spironolactone or Diane‐35 orally and applied 2% minoxidil topically, paired with biweekly scalp repair serum microneedle therapy sessions. After seven treatments, the scalp repair serum microneedle was discontinued, but oral administration and topical applications were continued, followed by a 1‐month follow‐up. Using a hair dermoscopy, hair follicles in a fixed region on the top of the head were manually counted per unit area to evaluate the hair restoration status of the patients quantitatively.ResultsAll 20 patients completed 3 months of combined therapy and a 1‐month follow‐up. On average, the patients experienced an increase of 42.6 hairs, with an efficiency rate of 100%. Significant differences were observed in hair count between any two of the first seven treatments (p < 0.001). A significant negative correlation was discovered between the initial pre‐treatment hair count and the total improvement of hair (p < 0.001), indicating that the greater the degree of hair loss before treatment, the more pronounced the improvement.ConclusionScalp repair serum microneedle combined therapy in moderate to severe androgenetic alopecia significantly reduces the number of microneedle treatments required, enhances treatment efficacy, and improves therapeutic outcomes.

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Section: Discussionmentioning

confidence: 91%

Observing the clinical efficacy of combined serum microneedle therapy for moderate to severe androgenetic alopecia in scalp repair

Zhang,

Jia,

et al. 2024

Skin Research and Technology

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“…[41][42][43][44][45] Silicon, metals, ceramics, and glass are the early reported materials used to fabricate microneedles, and they offer relatively high stiffnesses (over 10 GPa) and considerable mechanical strength to realize excellent tissue penetration. [46][47][48][49] However, they exhibit poor biocompatibility because they are non-degradable under normal conditions, which are easy to fracture after piercing and potentially have adverse effects on organisms. For polymers, they could adjust their crosslinking density, charge properties, and concentration to realize tunable drug release characteristics, but the fabrication of polymers microneedles is relatively time-consuming and complex.…”

Section: Methodsmentioning

confidence: 99%

Advanced Silk Fibroin Biomaterials‐Based Microneedles for Healthcare

Wang

et al. 2023

Macromolecular Bioscience

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Microneedles are a promising transdermal drug delivery system that has the advantages of minimal invasiveness, painlessness, and on‐demand drug delivery compared with commonly used medical techniques. Natural resources are developed as next‐generation materials for microneedles with varying degrees of success. Among them, silk fibroin is a natural polymer obtained from silkworms with good biocompatibility, high hardness, and controllable biodegradability. These properties provide many opportunities for integrating silk fibroin with implantable microneedle systems. In this review, the research progress of silk fibroin microneedles in recent years is summarized, including their materials, processing technology, detection, drug release methods, and applications. Besides, the research and development of silk fibroin in a multidimensional way are analyzed. Finally, it is expected that silk fibroin microneedles will have excellent development prospects in various fields.

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“…Microneedles are dense microscale needles placed in an array. For subcutaneous administration of cargo, the extraordinary delivery proportions, minimal invasion, and the cytokine generation stimulated by minor mechanical damage of microneedles are considered the new milestone for a variety of skin diseases. ,,, Microneedles are generally categorized as solid, hollow, coated, and dissolving microneedles. , …”

Section: Development Strategies For Drug Delivery Systems In Alopeciamentioning

confidence: 99%

“…47,139,196,197 Microneedles are generally categorized as solid, hollow, coated, and dissolving microneedles. 198,199 Yin et al 200 designed minoxidil-loaded PLGA microspheres delivered via microneedles (Figure 6). Minoxidil and PLGA in individual organic solutions were mixed with a poly(vinyl alcohol) solution and evaporated to form microspheres.…”

Section: Microneedlesmentioning

confidence: 99%

Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

Wu,

2023

Mol. Pharmaceutics

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Over 50% of the global population suffers from hair loss. The mixed results in the treatment of hair loss reveal the limitations of conventional commercial topical drugs. One the one hand, the definite pathogenesis of hair loss is still an enigma. On the other hand, targeted drug carriers ensure the drug therapeutic effect and low side effects. This review highlights the organization and overview of nine crucial signaling pathways associated with hair loss, as well as the development of nanobased topical delivery systems loading the clinical drugs, which will fuel emerging hair loss treatment strategies.

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Advances in microneedles research based on promoting hair regrowth

Cited by 31 publications

References 97 publications

Observing the clinical efficacy of combined serum microneedle therapy for moderate to severe androgenetic alopecia in scalp repair

Observing the clinical efficacy of combined serum microneedle therapy for moderate to severe androgenetic alopecia in scalp repair

Advanced Silk Fibroin Biomaterials‐Based Microneedles for Healthcare

Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

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