Advances in nanotechnology for diagnosis and treatment of tuberculosis

Abstract

This review covers the prospect of using nanotechnology for the detection of mycobacterial strains and nanotechnology-based drug delivery systems for effective eradication of mycobacterial infections.

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

“…The dendrimer-based system was found effective in delivery of rifampicin in tuberculosis treatment. Kumar et al (2006) 10 J. Singh et al Drug Deliv, suitable candidates as drug-delivery carriers (Li et al, 2009;Banyal et al, 2013). Generally, the polymeric nanoparticles can be made structurally more stable by selecting different kinds of polymers, different surfactants and organic solvents (Cekié et al, 2007;Ohashi et al, 2009;Kaur et al, 2014f).…”

Advancing Technologies for the Diagnosis and Management of Infections

“…Nanoparticle modification has improved isoniazid and rifampin delivery decreasing systemic toxicity. 36 Many of these processes require nanoparticle recognition of an epitope (a part of molecule or protein) found in the bacterial biofilm. Suci and colleagues 37 demonstrated that viral nanoparticles coated with antibodies to staphylococcal protein A (a surface protein and virulence factor) were markedly better able to target S aureus biofilms.…”

Shape and size engineered cellulosic nanomaterials as broad spectrum anti-microbial compounds

“…The uses of biodegradable nanoparticles in anti-TB drug delivery systems have been demonstrated to be effective [3]. Nanoparticle-based forays for treatment of tuberculosis has recently been reviewed, and found to be efficacious [4,5].…”