Advances in Nanotechnology for the Treatment of Osteoporosis

Abstract

Osteoporosis is a degenerative bone disease commonly related to aging. With an increase in life expectancies worldwide, the prevalence of the disease is expected to rise. Current clinical therapeutic treatments are not able to offer long-term solutions to counter the bone mass loss and the increased risk of fractures, which are the primary characteristics of the disease. However, the combination of bioactive nanomaterials within a biomaterial scaffold shows promise for the development of a localized, long-term treatment for those affected by osteoporosis. This review summarizes the unique characteristics of engineered nanoparticles that render them applicable for bone regeneration and recaps the current body of knowledge on nanomaterials with potential for osteoporosis treatment and bone regeneration. Specifically, we highlight new developments that are shaping this emerging field and evaluate applications of recently developed nanomaterials for osteoporosis treatment. Finally, we will identify promising new research directions in nanotechnology for bone regeneration.

Nanoengineered biomaterials for repair and regeneration of orthopedic tissue interfaces

“…Additionally, most of these new developed strategies are evaluated for bone-related applications and very limited studies focus on evaluating these new nanomaterials for other orthopedic tissues including cartilage, tendon, and ligament. [125][126][127] Thus there is a need to investigate these next generation of biomaterials for interface tissue engineering.…”

Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations

“…Some drugs such as insulin [20], paclitaxel [21], azithromycin [22], triamcinolone acetonide [23], methylprednisolone acetate [24], ibuprofen [25], naproxen [26], etc. [27][28][29][30][31][32][33][34] have been prepared by this method.…”

Management of Endodontic and Periodontal Lesions: the Role of Regenerative Dentistry and Biomaterials

“…Most of the literature converges on the fact that MSCs seeded on bECM-derived scaffolds are mostly able to differentiate towards osteogenic cells. bECM-derived scaffolds are, in fact, able to stimulate a higher mineral deposition by an up-regulation of both osteogenic genes and markers related to bone formation, compared to what happens with collagen scaffolds [14,15]. An issue in regenerative and reparative medicine is represented by graft survival after implantation: the survival rate strongly depends on the quality of graft vascularization.…”