Advances in novel iridium (III) based complexes for anticancer applications: A review

S, Ajay Sharma; Sudhindra, P; Roy, Nilmadhab; Paira, Priyankar

doi:10.1016/j.ica.2020.119925

Cited by 55 publications

(30 citation statements)

References 58 publications

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“…It has widely been used as key scaffold for design and preparation of novel drug candidate materials [20][21][22][23][24][25], supramolecular structures [26,27], polymers [28], and catalysts [29][30][31]. The essential vitamin B 6 , nicotine, redox NADP-NADPH 2 coenzymes and many other natural products possess pyridine ring in their structures so it is quite rational that pyridine-containing compounds continue to receive great synthetic attention in organic chemistry [32][33][34][35]. On the other hand, indole derivatives, which are another important class of nitrogen containing heterocyclic compounds, also play notable role as targets in synthesis of a variety of drugs such as zolmitriptan (migraine: 1), sumatriptan (migraine:2), tadalafil (erectile dysfunction: 3) and indomethacin (anti-inflammatory :4).…”

Section: Introductionmentioning

confidence: 99%

Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

Kalhor

Zarei

Sepehrmansourie

et al. 2021

Molecular Catalysis

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In this study, we have designed, synthesized and full characterized a novel biological based acidic nano organocatalyst via condensations reaction of uric acid and phosphorous acid. The obtained compound was named theacrine tetrakis(phosphonic acid) (TTPA) and prepared under refluxing ethanol. This new nano organocatalyst was applied as an efficient and recyclable catalyst for the preparation of novel pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation with good to excellent yields.

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Section: Introductionmentioning

confidence: 99%

Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

Kalhor

Zarei

Sepehrmansourie

et al. 2021

Molecular Catalysis

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“…The Group 9 metal complexes, in particular Iridium(III) complexes have been studied and reported in many applications including biomolecular probes [98–101] bioimaging [102–104] and photodynamic therapy (PDT) [105–107] In general, Ir(III) complexes have a wide absorption range in the ultraviolet to visible region, high photoluminescent quantum yield, relatively long lifetimes and large Stokes shift similar to Ru(II) and Re(I) complexes. Ir(III) complexes have shown near‐infrared emission with good penetration path due to the two‐photon absorption, improving the capability for bioimaging [108–110] .…”

Section: Iridium(iii) Complexesmentioning

confidence: 99%

Probing Amyloid Nanostructures Using Photoluminescent Metal Complexes

Jiang

Martí

2021

Eur J Inorg Chem

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Amyloid aggregates have been linked to the onset of multiple human neurodegenerative diseases, including Alzheimer's disease, Parkinson disease and type II diabetes. The detection of these aggregates is critical for understanding the mechanism and factors that lead to aggregation. In the recent decades, photoluminescence spectroscopy has been utilized to study amyloid aggregation, allowing the development of interesting therapeutic and diagnostic strategies. With the advancement of photoluminescence spectroscopy, metal complexes have led to the detection of amyloid aggregates due to their distinct properties. In the presence of amyloid aggregates, these metal complexes exhibit specific responses such as intensity changes, shift in emission wavelength, variations in lifetime and anisotropy changes. In this minireview, we provide an overview of the photoluminescent metal complexes used for the detection of amyloid aggregates, including Ru(II), Re(I), Ir(III) and Pt(II) complexes.

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“…In recent years, the research has underlined how a synthetic approach of this type allows great progress in the synthesis and optimization of competitive chemotherapy; however, the intrinsic reactivity and biological characteristics of platinum make it difficult to overcome many important therapeutic obstacles and the consequent achievement of an ideal pharmacology. Due to this fact, the use of alternative metals is becoming a valid possible answer to the problem [5,[12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes

et al. 2022

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Two novel phosphine ligands, Ph2PCH2N(CH2CH3)3 (1) and Ph2PCH2N(CH2CH2CH2CH3)2 (2), and six new metal (Cu(I), Ir(III) and Ru(II)) complexes with those ligands: iridium(III) complexes: Ir(η5-Cp*)Cl2(1) (1a), Ir(η5-Cp*)Cl2(2) (2a) (Cp*: Pentamethylcyclopentadienyl); ruthenium(II) complexes: Ru(η6-p-cymene)Cl2(1) (1b), Ru(η6-p-cymene)Cl2(2) (2b) and copper(I) complexes: [Cu(CH3CN)2(1)BF4] (1c), [Cu(CH3CN)2(2)BF4] (2c) were synthesized and characterized using elemental analysis, NMR spectroscopy, and ESI-MS spectrometry. Copper(I) complexes turned out to be highly unstable in the presence of atmospheric oxygen in contrast to ruthenium(II) and iridium(III) complexes. The studied Ru(II) and Ir(III) complexes exhibited promising cytotoxicity towards cancer cells in vitro with IC50 values significantly lower than that of the reference drug—cisplatin. Confocal microscopy analysis showed that Ru(II) and Ir(III) complexes effectively accumulate inside A549 cells with localization in cytoplasm and nuclei. A precise cytometric analysis provided clear evidence for the predominance of apoptosis in induced cell death. Furthermore, the complexes presumably induce the changes in the cell cycle leading to G2/M phase arrest in a dose-dependent manner. Gel electrophoresis experiments revealed that Ru(II) and Ir(III) inorganic compounds showed their unusual low genotoxicity towards plasmid DNA. Additionally, metal complexes were able to generate reactive oxygen species as a result of redox processes, proved by gel electrophoresis and cyclic voltamperometry. In vitro cytotoxicity assays were also carried out within multicellular tumor spheroids and efficient anticancer action on these 3D assemblies was demonstrated. It was proven that the hydrocarbon chain elongation of the phosphine ligand coordinated to the metal ions does not influence the cytotoxic effect of resulting complexes in contrast to metal ions type.

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Advances in novel iridium (III) based complexes for anticancer applications: A review

Cited by 55 publications

References 58 publications

Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

Probing Amyloid Nanostructures Using Photoluminescent Metal Complexes

Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino CuI, RuII, IrIII Complexes

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