Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications

Chong, Yu; Liu, Qiang; Ge, Cuicui

doi:10.1016/j.nantod.2021.101076

Cited by 212 publications

(107 citation statements)

References 151 publications

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“…Obtained results shown a dependency of the reaction rate with the nanozyme concentration ( Figure S6a,d ). Au@Pt nanozyme was highly active in a wide temperature range (i.e., 25–55 °C) ( Figure S6b,e ), a common feature among nanozymes [ 50 ]. In terms of pH, the optimal performance was found at pH = 4.0–4.5 ( Figure S6c,f ) which is also the typical values reported for oxidase-like nanozymes, such as CeO 2 or Pd [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Gold-Platinum Nanoparticles with Core-Shell Configuration as Efficient Oxidase-like Nanosensors for Glutathione Detection

et al. 2022

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Nanozymes, defined as nanomaterials that can mimic the catalytic activity of natural enzymes, have been widely used to develop analytical tools for biosensing. In this regard, the monitoring of glutathione (GSH), a key antioxidant biomolecule intervening in the regulation of the oxidative stress level of cells or related with Parkinson’s or mitochondrial diseases can be of great interest from the biomedical point of view. In this work, we have synthetized a gold-platinum Au@Pt nanoparticle with core-shell configuration exhibiting a remarkable oxidase-like mimicking activity towards the substrates 3,3′,5,5′-tetramethylbenzidine (TMB) and o-phenylenediamine (OPD). The presence of a thiol group (-SH) in the chemical structure of GSH can bind to the Au@Pt nanozyme surface to hamper the activation of O2 and reducing its oxidase-like activity as a function of the concentration of GSH. Herein, we exploit the loss of activity to develop an analytical methodology able to detect and quantify GSH up to µM levels. The system composed by Au@Pt and TMB demonstrates a good linear range between 0.1–1.0 µM to detect GSH levels with a limit of detection (LoD) of 34 nM.

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Section: Resultsmentioning

confidence: 99%

Gold-Platinum Nanoparticles with Core-Shell Configuration as Efficient Oxidase-like Nanosensors for Glutathione Detection

et al. 2022

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“…Oxidases catalytically oxidize substrate (electron donor) and produce H 2 O or H 2 O 2 in the presence of oxygen, which is served as the electron acceptor. The oxidase family is classified according to the acting group of donors, including amino groups, CH-OH group (GOx), Ph-OH group (polyphenol oxidase), sulfur group (sulfite oxidase, SuOx), and ferrous ions (ferroxidase and cytochrome c oxidase) [ 192 ]. Among them, the OXD-mimetic nanozymes that acting on amino groups were widely investigated.…”

Section: Properties Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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“…Recently, many inorganic nanomaterials have been found to catalyze the oxidation of substrates exhibiting oxidase-like activity such as Ce, noble metal, Mn, Fe, Cu, Mb. The oxidase-like activity can regulate their physicochemical parameters as size, shape, composition, and surface modification [ 96 , 111 ]. A capping agent can be used to obtain an excellent catalytic activity of nanozyme.…”

Section: Nanozyme Biosensorsmentioning

confidence: 99%

Enzyme (Single and Multiple) and Nanozyme Biosensors: Recent Developments and Their Novel Applications in the Water-Food-Health Nexus

et al. 2021

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The use of sensors in critical areas for human development such as water, food, and health has increased in recent decades. When the sensor uses biological recognition, it is known as a biosensor. Nowadays, the development of biosensors has been increased due to the need for reliable, fast, and sensitive techniques for the detection of multiple analytes. In recent years, with the advancement in nanotechnology within biocatalysis, enzyme-based biosensors have been emerging as reliable, sensitive, and selectively tools. A wide variety of enzyme biosensors has been developed by detecting multiple analytes. In this way, together with technological advances in areas such as biotechnology and materials sciences, different modalities of biosensors have been developed, such as bi-enzymatic biosensors and nanozyme biosensors. Furthermore, the use of more than one enzyme within the same detection system leads to bi-enzymatic biosensors or multi-enzyme sensors. The development and synthesis of new materials with enzyme-like properties have been growing, giving rise to nanozymes, considered a promising tool in the biosensor field due to their multiple advantages. In this review, general views and a comparison describing the advantages and disadvantages of each enzyme-based biosensor modality, their possible trends and the principal reported applications will be presented.

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Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications

Cited by 212 publications

References 151 publications

Gold-Platinum Nanoparticles with Core-Shell Configuration as Efficient Oxidase-like Nanosensors for Glutathione Detection

Gold-Platinum Nanoparticles with Core-Shell Configuration as Efficient Oxidase-like Nanosensors for Glutathione Detection

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Enzyme (Single and Multiple) and Nanozyme Biosensors: Recent Developments and Their Novel Applications in the Water-Food-Health Nexus

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