Advances in plant molecular farming

Obembe, Olawole O.; Popoola, Jacob O.; Leelavathi, Sadhu; Reddy, Siva V.

doi:10.1016/j.biotechadv.2010.11.004

Cited by 238 publications

(207 citation statements)

References 190 publications

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“…Alterations of the plastid genome represent a promising possibility for high-level, clean, and safe expression of proteins (and other products) in cost-effective commercial applications. The advantages and challenges of plant molecular pharming are extensively reviewed elsewhere Daniell 2006;Bock 2007Bock , 2014Verma and Daniell 2007;Chebolu and Daniell 2009;Rybicki 2009;Bock and Warzecha 2010;Cardi et al 2010;Meyers et al 2010;Wani et al 2010;Lössl and Waheed 2011;Maliga and Bock 2011;Obembe et al 2011;Scotti et al 2012;Ahmad and Mukhtar 2013). Although several plastid-derived vaccine antigenes have already been tested in animal models (Lössl and Waheed 2011), to our knowledge no transplastomic plants have been licensed for biopharmaceutical use (Section 4).…”

Section: Molecular Pharming-accumulation Of Recombinant Proteinsmentioning

confidence: 99%

Transplastomic plants for innovations in agriculture. A review

Wani

Sah

Sági

et al. 2015

Agron. Sustain. Dev.

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Food production has to be significantly increased in order to feed the fast growing global population estimated to be 9.1 billion by 2050. The Green Revolution and the development of advanced plant breeding tools have led to a significant increase in agricultural production since the 1960s. However, hundreds of millions of humans are still undernourished, while the area of total arable land is close to its maximum utilization and may even decrease due to climate change, urbanization, and pollution. All these issues necessitate a second Green Revolution, in which biotechnological engineering of economically and nutritionally important traits should be critically and carefully considered. Since the early 1990s, possible applications of plastid transformation in higher plants have been constantly developed. These represent viable alternatives to existing nuclear transgenic technologies, especially due to the better transgene containment of transplastomic plants. Here, we present an overview of plastid engineering techniques and their applications to improve crop quality and productivity under adverse growth conditions. These applications include (1) transplastomic plants producing insecticidal, antibacterial, and antifungal compounds. These plants are therefore resistant to pests and require less pesticides. (2) Transplastomic plants resistant to cold, drought, salt, chemical, and oxidative stress. Some pollution tolerant plants could even be used for phytoremediation. (3) Transplastomic plants having higher productivity as a result of improved photosynthesis. (4) Transplastomic plants with enhanced mineral, micronutrient, and macronutrient contents. We also evaluate field trials, biosafety issues, and public concerns on transplastomic plants. Nevertheless, the transplastomic technology is still unavailable for most staple crops, including cereals. Transplastomic plants have not been commercialized so far, but if this crop limitation were overcome, they could contribute to sustainable development in agriculture.

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Section: Molecular Pharming-accumulation Of Recombinant Proteinsmentioning

confidence: 99%

Transplastomic plants for innovations in agriculture. A review

Wani

Sah

Sági

et al. 2015

Agron. Sustain. Dev.

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“…Further, another problem of PEVs is rooted in gene flow. 7 According to Cartagena protocols on biosafety, the genetically manipulated (GM) plants must be cultured cautiously in guaranteed fields. 8 However, it seems that most developing countries neither do precisely execute the articles of biosafety nor meet the certain rules/regulations in this regard.…”

Section: Limitations Of Plant Systems For Production Of Edible Vaccinesmentioning

confidence: 99%

The search for a promising cell factory system for production of edible vaccine

Saeedi

Zarredar²,

Barar

et al. 2014

Human Vaccines & Immunotherapeutics

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“…Four PMPs have already been launched on the market, in addition to three previously commercialized proteins derived from maize, bovine trypsin, avidin, and β-glucuronidase, all of which have been utilized in research laboratories worldwide since 1998 (Table 1) (Ma et al, 2003;Obembe et al, 2011).…”

Section: Introductionmentioning

confidence: 99%