Advances in real-time multispectral optoacoustic imaging and its applications

Taruttis, Adrian; Ntziachristos, Vasilis

doi:10.1038/nphoton.2015.29

Cited by 537 publications

(476 citation statements)

References 98 publications

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“…The ability of MSOT to differentiate multiple spectral signatures based on tissue optical absorption offers an additional dimension absent from ultrasonography, which provides only a "monochromatic" image of acoustic im- pedance differences [9]. Advantageously, MSOT can distinguish tissue types based on molecular composition, in particular for photoabsorbing molecules such as hemoglobin and fat.…”

Section: Discussionmentioning

confidence: 99%

Imaging of fatty tumors: appearance of subcutaneous lipomas in optoacoustic images

et al. 2017

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A wide variety of subcutaneous soft-tissue masses may be seen in clinical practice. Clinical examination based on palpation alone is often insufficient to identify the nature and exact origin of the mass, in which case imaging is necessary. We used handheld multispectral optoacoustic imaging technology (MSOT) in a proof-of-principle study to image superficial fatty tumors and compare the images with diagnostic ultrasound. Fatty tumors were clearly visualized by MSOT and exhibited a spectral signature which differed from normal fatty tissue or muscle tissue. Our findings further indicated that MSOT offers highly complementary contrast to sonography. Based on the performance achieved, we foresee a promising role for MSOT in the diagnosis and evaluation of subcutaneous soft-tissue masses.Picture: Pseudo-color representation of a cross-sectional multi-spectral optoacoustic slice through a subcutaneous lipoma. Multi-spectral information is encoded in color. The lipoma can clearly be distinguished from the surrounding tissue based on its color. Scalebar 1 cm.

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Section: Discussionmentioning

confidence: 99%

Imaging of fatty tumors: appearance of subcutaneous lipomas in optoacoustic images

et al. 2017

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“…We have shown that image quality significantly improves when using curved ultrasound detectors, over linear detectors [5]. Moreover, recent development of fast-tuning lasers offering >50 mJ energy per pulse has allowed the application of single-pulse-per-frame (SPPF) acquisition [6], which uses a single laser pulse to collect a cross-sectional image from tissue without averaging data from multiple pulses. SPPF minimizes motion artifacts and allows image collection at >50 Hz frame rates.…”

Section: Introductionmentioning

confidence: 99%

Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept

Karlas

Reber

Diot

et al. 2017

Biomed. Opt. Express

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Label-free multispectral optoacoustic tomography (MSOT) has recently shown superior performance in visualizing the morphology of human vasculature, especially of smaller vessels, compared to ultrasonography. Herein, we extend these observations towards MSOT interrogation of macrovascular endothelial function. We employed a real-time handheld MSOT scanner to assess flow-mediated dilatation (FMD), a technique used to characterize endothelial function. A data processing scheme was developed to quantify the dimensions and diameter changes of arteries in humans and determine wall distensibility parameters. By enabling high-resolution delineation of the blood-vessel wall in a crosssectional fashion, the findings suggest MSOT as a capable alternative to ultrasonography for clinical FMD measurements.

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“…In addition they are associated with several drawbacks such as being invasive, requiring contrast agents with potential side effects or delivering high doses of radiation that may increase cancer risks. Non-invasive direct measurements of oxygenation are currently being investigated, including CMR using the Blood Oxygen-Level Dependent (BOLD) scheme [2], Photo-Acoustic Tomography (PAT) [3] and Ultrasound Optical Tomography (UOT) [4]. The BOLD CMR scheme has so far shown limited contrast-to-noise ratios and susceptibility to artifacts [2], in addition to being an expensive and complicated method.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)

Walther¹,

Rippe²,

Wang³

et al. 2017

Biomed. Opt. Express

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Despite the important medical implications, it is currently an open task to find optical non-invasive techniques that can image deep organs in humans. Addressing this, photo-acoustic tomography (PAT) has received a great deal of attention in the past decade, owing to favorable properties like high contrast and high spatial resolution. However, even with optimal components PAT cannot penetrate beyond a few centimeters, which still presents an important limitation of the technique. Here, we calculate the absorption contrast levels for PAT and for ultrasound optical tomography (UOT) and compare them to their relevant noise sources as a function of imaging depth. The results indicate that a new development in optical filters, based on rare-earth-ion crystals, can push the UOT technique significantly ahead of PAT. Such filters allow the contrastto-noise ratio for UOT to be up to three orders of magnitude better than for PAT at depths of a few cm into the tissue. It also translates into a significant increase of the image depth of UOT compared to PAT, enabling deep organs to be imaged in humans in real time. Furthermore, such spectral holeburning filters are not sensitive to speckle decorrelation from the tissue and can operate at nearly any angle of incident light, allowing good light collection. We theoretically demonstrate the improved performance in the medically important case of non-invasive optical imaging of the oxygenation level of the frontal part of the human myocardial tissue. Our results indicate that further studies on UOT are of interest and that the technique may have large impact on future directions of biomedical optics.

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Advances in real-time multispectral optoacoustic imaging and its applications

Cited by 537 publications

References 98 publications

Imaging of fatty tumors: appearance of subcutaneous lipomas in optoacoustic images

Imaging of fatty tumors: appearance of subcutaneous lipomas in optoacoustic images

Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept

Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)

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