Advances in Research on the Effects and Mechanisms of Chemokines and Their Receptors in Cancer

Xu, Jing; Li, Jingquan; Chen, Qi-lei; Shestakova, Elena; Misyurin, V. A.; Pokrovsky, Vadim S.; Tchevkina, Elena M.; Chen, Hubiao; Song, Hang; Zhang, Jianye

doi:10.3389/fphar.2022.920779

Cited by 5 publications

(1 citation statement)

References 118 publications

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“…It’s known that different immune cell subsets can be recruited into TME via interactions between chemokines and chemokine receptors, and affect tumor progression and therapeutic outcome [ 66 ]. Chemokines (CXCL12 [ 67 ], CXCL8 [ 68 ], CXCL5 [ 69 ]) and chemokine receptors (CXCR1/2 [ 70 ], CCR4 [ 71 , 72 ], CCR8 [ 73 ]) are well-known to deeply participate in the tumor development and progression in various cancers, including LUAD [ 74 ]. In the present study, we found that the expression of KIAA1199 was correlated with the levels of many chemokines (CXCL12, CXCL8, CXCL5) and chemokine receptors (CXCR1/2, CXCR4, CCR8) in LUAD.…”

Section: Discussionmentioning

confidence: 99%

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker

Shen¹,

Mo²,

Tan³

et al. 2022

Pathol. Oncol. Res.

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Background: KIAA1199 has been considered a key regulator of carcinogenesis. However, the relationship between KIAA1199 and immune infiltrates, as well as its prognostic value in lung adenocarcinoma (LUAD) remains unclear.Methods: The expression of KIAA1199 and its influence on tumor prognosis were analyzed using a series of databases, comprising TIMER, GEPIA, UALCAN, LCE, Prognoscan and Kaplan-Meier Plotter. Further, immunohistochemistry (IHC), western blot (WB) and receiver operating characteristic (ROC) curve analyses were performed to verify our findings. The cBioPortal was used to investigate the genomic alterations of KIAA1199. Prediction of candidate microRNA (miRNAs) and transcription factor (TF) targeting KIAA1199, as well as GO and KEGG analyses, were performed based on LinkedOmics. TIMER and TISIDB databases were used to explore the relationship between KIAA1199 and tumor immune infiltration.Results: High expression of KIAA1199 was identified in LUAD and Lung squamous cell carcinoma (LUSC) patients. High expression of KIAA1199 indicated a worse prognosis in LUAD patients. The results of IHC and WB analyses showed that the expression level of KIAA1199 in tumor tissues was higher than that in adjacent tissues. GO and KEGG analyses indicated KIAA1199 was mainly involved in extracellular matrix (ECM)-receptor interaction and extracellular matrix structure constituent. KIAA1199 was positively correlated with infiltrating levels of CD4+ T cells, macrophages, neutrophil cells, dendritic cells, and showed positive relationship with immune marker subsets expression of a variety of immunosuppressive cells.Conclusion: High expression of KIAA1199 predicts a poor prognosis of LUAD patients. KIAA1199 might exert its carcinogenic role in the tumor microenvironment via participating in the extracellular matrix formation and regulating the infiltration of immune cells in LUAD. The results indicate that KIAA1199 might be a novel biomarker for evaluating prognosis and immune cell infiltration in LUAD.

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Section: Discussionmentioning

confidence: 99%

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker

Shen¹,

Mo²,

Tan³

et al. 2022

Pathol. Oncol. Res.

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Chemokines and Their Receptors: Predictors of Therapeutic Potential in Tumor Microenvironment on Esophageal Cancer

Huang,

Liu,

Zheng

et al. 2024

Dig Dis Sci

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The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

Yoshimura

Wang

et al. 2023

Cell Mol Immunol

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Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause of death in cancer patients. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was isolated from the culture supernatants of not only mitogen-activated peripheral blood mononuclear leukocytes but also malignant glioma cells based on its in vitro chemotactic activity toward human monocytes. MCP-1 was subsequently found to be identical to a previously described tumor cell-derived chemotactic factor thought to be responsible for the accumulation of tumor-associated macrophages (TAMs), and it became a candidate target of clinical intervention; however, the role of TAMs in cancer development was still controversial at the time of the discovery of MCP-1. The in vivo role of MCP-1 in cancer progression was first evaluated by examining human cancer tissues, including breast cancers. Positive correlations between the level of MCP-1 production in tumors and the degree of TAM infiltration and cancer progression were established. The contribution of MCP-1 to the growth of primary tumors and metastasis to the lung, bone, and brain was examined in mouse breast cancer models. The results of these studies strongly suggested that MCP-1 is a promoter of breast cancer metastasis to the lung and brain but not bone. Potential mechanisms of MCP-1 production in the breast cancer microenvironment have also been reported. In the present manuscript, we review studies in which the role of MCP-1 in breast cancer development and progression and the mechanisms of its production were examined and attempt to draw a consensus and discuss the potential use of MCP-1 as a biomarker for diagnosis.

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Advances in Research on the Effects and Mechanisms of Chemokines and Their Receptors in Cancer

Cited by 5 publications

References 118 publications

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker

Chemokines and Their Receptors: Predictors of Therapeutic Potential in Tumor Microenvironment on Esophageal Cancer

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

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