One of the most crucial aspects of image segmentation is multilevel thresholding. However, multilevel thresholding becomes increasingly more computationally complex as the number of thresholds grows. In order to address this defect, this paper proposes a new multilevel thresholding approach based on the Evolutionary Arithmetic Optimization Algorithm (AOA). The arithmetic operators in science were the inspiration for AOA. DAOA is the proposed approach, which employs the Differential Evolution technique to enhance the AOA local research. The proposed algorithm is applied to the multilevel thresholding problem, using Kapur’s measure between class variance functions. The suggested DAOA is used to evaluate images, using eight standard test images from two different groups: nature and CT COVID-19 images. Peak signal-to-noise ratio (PSNR) and structural similarity index test (SSIM) are standard evaluation measures used to determine the accuracy of segmented images. The proposed DAOA method’s efficiency is evaluated and compared to other multilevel thresholding methods. The findings are presented with a number of different threshold values (i.e., 2, 3, 4, 5, and 6). According to the experimental results, the proposed DAOA process is better and produces higher-quality solutions than other comparative approaches. Moreover, it achieved better-segmented images, PSNR, and SSIM values. In addition, the proposed DAOA is ranked the first method in all test cases.