Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration

Foroushani, Fatemeh Tavakoli; Dzobo, Kevin; Khumalo, Nonhlanhla P.; Mora, Vanessa Zamora; Mezerville, Roberto de

doi:10.1186/s40824-022-00314-1

Cited by 16 publications

(1 citation statement)

References 299 publications

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“…Breast implants are designed to improve the appearance of the breasts, restore breast volume after mastectomy, or correct breast asymmetry. Breast implants can fail because of implant rupture, capsular contracture, and infection [36].…”

Section: Brief Overview Of Current Types Of Medical Implantsmentioning

confidence: 99%

An Overview of Enhancing the Performance of Medical Implants with Nanocomposites

Ramezani

Ripin

2023

J. Compos. Sci.

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Medical implants are essential tools for treating chronic illnesses, restoring physical function, and improving the quality of life for millions of patients worldwide. However, implant failures due to infection, mechanical wear, corrosion, and tissue rejection continue to be a major challenge. Nanocomposites, composed of nanoparticles or nanofillers dispersed in a matrix material, have shown promising results in enhancing implant performance. This paper provides an overview of the current state of research on the use of nanocomposites for medical implants. We discuss the types of nanocomposites being developed, including polymer-, metal-, and ceramic-based materials, and their advantages/disadvantages for medical implant applications. Strategies for improving implant performance using nanocomposites, such as improving biocompatibility and mechanical properties and reducing wear and corrosion, are also examined. Challenges to the widespread use of nanocomposites in medical implants are discussed, such as biocompatibility, toxicity, long-term stability, standardisation, and quality control. Finally, we discuss future directions for research, including the use of advanced fabrication techniques and the development of novel nanocomposite materials. The use of nanocomposites in medical implants has the potential to improve patient outcomes and advance healthcare, but continued research and development will be required to overcome the challenges associated with their use.

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Section: Brief Overview Of Current Types Of Medical Implantsmentioning

confidence: 99%

An Overview of Enhancing the Performance of Medical Implants with Nanocomposites

Ramezani

Ripin

2023

J. Compos. Sci.

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Experimental study on the cytocompatibility of milling surface of poly-ether-ether-ketone (PEEK)

Liu

Qian

2023

Int J Adv Manuf Technol

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Cytocompatibility of implant material is dependent on the processed surface topography. This study aimed to characterize the milling surface topography features and to assess the cytotoxicity of PEEK processed using end milling technology. Based on the Taguchi method, end milling experiments have been conducted on PEEK to characterize surface topographies induced by various milling conditions. Machined surface defects and 3-Dimensional surface topography parameters such as surface average height Sa, the tenpoint height of surface Sz, Skewness Ssk, and Kurtosis Sku were characterized. The relationships between the cutting technological parameters and surface topography parameters were established by developing a linear regression model. On the other hand, the effect of the machined surface topography on the viability of fibroblasts was investigated by using cells from a mouse fibroblast L929 and the agar overlay test, MTT test. The experimental result indicated that feed marks, scratch marks, budlike protuberances, the adhered surface particles are the main forms of the surface defect in the end milling of PEEK. The axial and radial depths of cut are the two most critical factors to affect surface topography parameters. Agar overlay tests produced no evidence of cell damage caused by PEEK, and a conclusion can be drawn that PEEK has no cytotoxicity to L929 cell. MTT test results indicated that milling-induced surface topography features exerted specific toxicity on L929 cells, and a statistical difference between the cell's viability of the test samples is observable. By correlation analysis, the correlations order of the viability of fibroblasts L929 with the machined surface roughness parameters were Ssk, Sa, Sku and Sz in large to small. It is concluded that end milling processing significantly affects surface topography which in turn influences the L929 fibroblast cellular response.A significant decrease of L929 viability started with the surface roughness of Sa = 1.18 μm, and surface roughness characterized by Ssk = 0.011 (namely, Ssk closed to zero) also 2 / 23 allowed to achieve the highest possible cells viability.

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INVITED DISCUSSION ON: Prepectoral Versus Subpectoral Direct-to-Implant Breast Reconstruction: Evaluation of Patient’s Quality of Life and Satisfaction with BREAST-Q

Pelle-Ceravolo

Vita²

2023

Aesth Plast Surg

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Advances in surface modifications of the silicone breast implant and impact on its biocompatibility and biointegration

Cited by 16 publications

References 299 publications

An Overview of Enhancing the Performance of Medical Implants with Nanocomposites

An Overview of Enhancing the Performance of Medical Implants with Nanocomposites

Experimental study on the cytocompatibility of milling surface of poly-ether-ether-ketone (PEEK)

INVITED DISCUSSION ON: Prepectoral Versus Subpectoral Direct-to-Implant Breast Reconstruction: Evaluation of Patient’s Quality of Life and Satisfaction with BREAST-Q

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