Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection

Abstract

Efforts have been made to enhance the surface sensitivity of the conventional surface plasmon resonance biosensor. To improve the sensitivity, a unique two-dimensional heterostructure layer of titanium disilicide and black phosphorus layer has been deposited over the metal surface. The titanium disilicide (TiSi2) nanosheet is placed in between silver (Ag) and black phosphorus (BP) films in the Kretschmann arrangement. This biosensor executes better over a wide range of refractive index variations, including biological cell distribution in individual blood. It may become a fast method of detecting cancerous cells and the several variants of corona and other viruses that become pandemic. Using the finite element method-based simulation technique, the sensitivity obtained as 195.4 degree/RIU, 167.6 degree/RIU, 212.4 degree/RIU, 168.4 degree/RIU, 212.4 degree/RIU, 186.6 degree/RIU, 218.6 degree/RIU, 195.4 degree/RIU, 203.6 degree/RIU, 202.6 degree/RIU 203.6 degree/RIU, and 202.6 for basal (skin cancer), basal (normal cell), HeLa (cervical cancer), MCF-7 (breast cancer), HeLa (normal cell), Jurkat (blood cancer), Jurkat (normal cell), PCI-2 (adrenal gland cancer), PCI-2 (normal cell), MDA-MB-231 (breast cancer), MDA-MB-231 (normal cell), MCF-7 (breast cancer), and MCF-7 (normal cell), respectively, and other performance parameters such as detection accuracy, figure of merit, and full width and half maximum (FWHM) are also evaluated.

Advances in surface plasmon resonance–based biosensor technologies for Cancer Cell detection

“…e sensitivity and detection accuracy are the performance parameters of the biosensor [38], and the same is computed for the proposed biosensor. e sensitivity of the biosensor is represented as S � δθ SPR /δn, where δn is the change in the RI.…”

Early detection of Chikungunya virus utilizing the Surface Plasmon Resonance comprising of Silver-Silicon-PtSe 2 Multi-Layer Structure

“…Under TIR circumstances, the photon permeates the metal and passes its energy to oscillating electrons, causing SPR. This happens when the incidence wave vector (Ki) matches the surface plasmon wave vector (Kp) [18]. Light alone can't excite the The suggested biosensor is envisaged to comprise five layers consisting of Figure 1.…”

Photonic crystal fiber (PhCF) for petrochemical sensing

“…Habib et al also reported a hollow-core PhCF sensor with a sensitivity of ≃89% [20]. Moreover, Karki and his group reported an advanced SPR biosensor for detecting cancer cells [22]. This group also presented another biosensor for Hemoglobin detection [23].…”