Advances in the alkylsilyl derivatization of glyphosate and aminomethylphosphonic acid: A critical comeback to the N - tert .-butyldimethylsilyl- N -methyltrifluoroacetamide reagent

Arkan, T.; Molnár-Perl, I.

doi:10.1016/j.microc.2017.02.004

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…The very stable tert ‐butyl radical results in most of the spectra of TBDMS derivatized compounds displaying very abundant [M − tert ‐C 4 H 9 • ] + ([M − 57] + ) ions (Millington, ; Ogilvie, ; Phillipou et al, ; Watson & Sweetman, ). A typical spectrum is shown in Figure c, Consequently, these derivatives are favourites for selected ion monitoring work and a large number of applications have been published up to the present day (Arkan & Molnár‐Perl, ). These applications are too numerous to be included in the present review and only a few will be discussed.…”

Section: Other Silyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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This review describes the mass spectral fragmentation of trimethylsilyl (TMS) and related alkylsilyl derivatives used for preparing samples for analysis, mainly by combined gas chromatography and mass spectrometry (GC/MS). The review is divided into three sections. The first section is concerned with the TMS derivatives themselves and describes fragmentation of derivatized alcohols, thiols, amines, ketones, carboxylic acids and bifunctional compounds such as hydroxy‐ and amino‐acids, halo acids and hydroxy ethers. More complex compounds such as glycerides, sphingolipids, carbohydrates, organic phosphates, phosphonates, steroids, vitamin D, cannabinoids, and prostaglandins are discussed next. The second section describes intermolecular reactions of siliconium ions such as the TMS cation and the third section discusses other alkylsilyl derivatives. Among these latter compounds are di‐ and trialkyl‐silyl derivatives, various substituted‐alkyldimethylsilyl derivatives such as the tert‐butyldimethylsilyl ethers, cyclic silyl derivatives, alkoxysilyl derivatives, and 3‐pyridylmethyldimethylsilyl esters used for double bond location in fatty acid spectra. © 2019 Wiley Periodicals, Inc. Mass Spec Rev 0000:1–107, 2019

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Section: Other Silyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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“…The quantification of trace concentrations of GLY and AMPA represents a challenging issue due to the high polar, zwitterion character, low molecular weight, and ligand properties of both species. Derivatization of polar moieties in the structure of both compounds (i.e., using a combination of trifluoroacetic acid and trifluoroethanol [ 6 ], or a silylation reagent [ 7 ]) allows their determination by gas chromatography-mass spectrometry (GC–MS) [ 6 , 8 ]. However, liquid chromatography-mass spectrometry (LC–MS) remains the most resorted technique for the quantification of GLY and AMPA in environmental and food samples.…”

Section: Introductionmentioning

confidence: 99%

Approaches to liquid chromatography tandem mass spectrometry assessment of glyphosate residues in wine

et al. 2021

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The performance of two different analytical methodologies to investigate the presence of glyphosate (GLY) and aminomethylphosphonic acid (AMPA) residues in wine samples was evaluated. Transformation of compounds in their fluorene-9-methyloxycarbonyl derivatives permitted their separation under reversed-phase liquid chromatography with tandem mass spectrometry (LC–MS/MS) determination. Although the wine matrix severely impaired the efficiency of GLY derivatization, this drawback was solved using a molecularly imprinted sorbent for the previous, selective extraction of GLY and AMPA from wine. Alternatively, the use of a strong anionic exchange, polyvinyl alcohol-based LC column, turned to be the most effective alternative for direct determination of both compounds in diluted wine samples. The chromatographic behavior of this column and the magnitude of matrix effects observed during analysis of diluted wine samples were significantly affected by the composition of the mobile phase. Under final working conditions, this column permitted the separation of AMPA and the fungicide fosetyl (which shows common transitions in tandem MS/MS methods), it improved significantly the sample throughput versus extraction-derivatization-purification method, and it allowed the use of solvent-based calibration standards. Both analytical procedures provided similar limits of quantification (LOQs) for GLY (0.5–1.0 ng mL−1), while the multistep method was 8 times more sensitive to AMPA than the direct procedure. GLY residues stayed above method LOQs in 70% of the processed wines; however, concentrations measured in 95% of positive samples remained 100 times below the maximum residue limit (MRL) set for GLY in vinification grapes. Graphical abstract

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Direct, automated and sensitive determination of glyphosate and related anionic pesticides in environmental water samples using solid-phase extraction on-line combined with liquid chromatography tandem mass spectrometry

López-Vázquez

Pérez-Mayán

Fernández-Fernández

et al. 2023

Journal of Chromatography A

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Advances in the alkylsilyl derivatization of glyphosate and aminomethylphosphonic acid: A critical comeback to the N - tert .-butyldimethylsilyl- N -methyltrifluoroacetamide reagent

Cited by 5 publications

References 9 publications

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Approaches to liquid chromatography tandem mass spectrometry assessment of glyphosate residues in wine

Direct, automated and sensitive determination of glyphosate and related anionic pesticides in environmental water samples using solid-phase extraction on-line combined with liquid chromatography tandem mass spectrometry

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