2014
DOI: 10.1111/jcmm.12270
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Advances in the cellular immunological pathogenesis of type 1 diabetes

Abstract: Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of insulin-producing pancreatic β cells. In recent years, the incidence of type 1 diabetes continues to increase. It is supposed that genetic, environmental and immune factors participate in the damage of pancreatic β cells. Both the immune regulation and the immune response are involved in the pathogenesis of type 1 diabetes, in which cellular immunity plays a significant role. For the infiltration of CD4+ and CD8+ T lymphocyte… Show more

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Cited by 62 publications
(36 citation statements)
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“…Immunological abnormalities such as abnormal expression of NK cell surface markers and abnormal cytokine production may also be associated with the pathogenesis of DM. In fact, some researchers had reported decreased expression of NKp46 and changed levels of serum cytokines such as IFN‐γ, TNF‐α, TGF‐β, and VEGF in patients with DM . Recently, the relationship between immune response and metabolic diseases such as obesity, type 2 diabetes, and GDM was reported …”
Section: Discussionmentioning
confidence: 99%
“…Immunological abnormalities such as abnormal expression of NK cell surface markers and abnormal cytokine production may also be associated with the pathogenesis of DM. In fact, some researchers had reported decreased expression of NKp46 and changed levels of serum cytokines such as IFN‐γ, TNF‐α, TGF‐β, and VEGF in patients with DM . Recently, the relationship between immune response and metabolic diseases such as obesity, type 2 diabetes, and GDM was reported …”
Section: Discussionmentioning
confidence: 99%
“…Type 1 diabetes (T1D) is an autoimmune disease in which insulin-secreting pancreatic β cells are selectively destroyed by self-reactive immune responses that are dictated by proinflammatory cytokines (1-3). Isoflavones in soy exert weak estrogen-like (i.e., phytoestrogenic) effects, and the major components in the isoflavone family are genistein (GEN), diadzein, and glycitein.…”
Section: Introductionmentioning
confidence: 99%
“…Especially, the number of cytokine regulating pathways were increased manifold, where more than half were unique to this time-window. Along with anti-inflammatory cytokines, such as IL-10 and IL-4 [Qiao et al, 2016;Borish et al, 2003;Souto et al, 2014], many pro-inflammatory cytokine regulating pathways were enriched, such as IL-1, IL-1β, IL-5 [Borish et al, 2003], IL-6 [Souto et al, 2014;Borish et al, 2003], IL-12 [Mbongue et al, 2017], IL-21 [Bending et al, 2012;Clark et al, 2017;Li et al, 2014], IL-22 [Borish et al, 2003], IFNγ, TNF-α. In the absence of IFNγ and TNF-α, cytokines IL-2, IL-1β and IL-6 are considered anti-inflammatory [Souto et al, 2014;Clark et al, 2017;Bending et al, 2012;Hartemann and Bourron, 2012;Pérol et al, 2016;Borish et al, 2003], but in their presence, these cytokines aggravate the inflammatory disease pattern, which is probably the case in the time time-window before T1D diagnosis.…”
Section: Discussionmentioning
confidence: 99%