Advances in the clinical use of collagen as biomarker of liver fibrosis

Meurer, Steffen K.; Karsdal, Morten A.; Weiskirchen, Ralf

doi:10.1080/14737159.2020.1814746

Cited by 12 publications

(10 citation statements)

References 165 publications

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“…Moreover, the histochemical section of the liver of the liver fibrosed animals which displayed the severe elastic collagen fibers deposition that stained blue around of portal vein revealed to perivascular fibrosis. Nearly similar results clarified by 12 who reported that the collagen fibers which stained blue moreover, the cytoplasm of hepatocytes are stained red with this histochemical stain. The above results were consistent with our microscopical results, which showed severe area of fibrosis particularly in the pericentral vein region as well to the portal area of the affected liver.…”

Section: Discussionsupporting

confidence: 80%

Pathological Evaluation of Canine Hepatic Cirrhosis and Necro-inflammatory Activity

Shahad Saad Mahdi,

Jihad Abdulameer Ahmed

2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Hepatic fibrosis is a common pathological result of chronic liver diseases, which is a dynamic process of liver decomposition mediated by cellular mediators in response to injury.Objective: The present study aims to evaluate the histopathological features of dog-liver fibrosis and / or cirrhosis.Materials and Methods: 40 liver samples were collected; 12 liver fibrosis suspected animals were performed the histopathology to determine the main features of canine liver fibrosis. Results:The histopathology revealed chronic hepatitis with liver islands separated by strips of fibroblasts and collagen, moderate numbers of macrophages, lymphocytes and plasma cells. Also in fibrosis between chronic hepatitis/cirrhosis had a wide range of severity and inflammation was observed primarily around fibrous tissue or was surrounded by fibrous tissue but extended to the liver parenchyma. The histochemical study revealed to a deposition of collagen fibers in the portal, subscapular and interlobular regions. Conclusion:The histopathology revealed a range of lesions vary from mild hepatic degenerative changes to severe fibrotic features associated with canine hepatic fibrosis and early cirrhosis.

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Section: Discussionsupporting

confidence: 80%

Pathological Evaluation of Canine Hepatic Cirrhosis and Necro-inflammatory Activity

Shahad Saad Mahdi,

Jihad Abdulameer Ahmed

2021

Indian Journal of Forensic Medicine & Toxicology

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“…Without timely and valid treatment, liver fibrosis might finally develop into end-stage cirrhosis. The mechanisms of liver fibrosis are complex, consisting of inflammation, hepatic stellate cell (HSC) activation, extracellular matrix (ECM) production, and the deposit of collagen in liver [ 61 , 62 ]. Therefore, liver fibrosis can be reversed via ceasing chronic liver damage, blocking inflammation, deactivating HSCs, and degrading ECM [ 63 ].…”

Section: Polysaccharides In Different Liver Diseasesmentioning

confidence: 99%

The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases

Ren

Song

et al. 2022

Nutrients

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Liver disease is a global health burden with high morbidity and mortality worldwide. Liver injuries can develop into severe end-stage diseases, such as cirrhosis or hepatocellular carcinoma, without valid treatment. Therefore, identifying novel drugs may promote liver disease treatment. Phytochemicals, including polysaccharides, flavonoids, alkaloids, and terpenes, are abundant in foods and medicinal plants and have various bioactivities, such as antioxidation, immunoregulation, and tumor killing. Recent studies have shown that many natural polysaccharides play protective roles in liver disease models in vitro and in vivo, such as fatty liver disease, alcoholic liver disease, drug-induced liver injury, and liver cancer. The mechanisms of liver disease are complex. Notably, ferroptosis, a new type of cell death driven by iron and lipid peroxidation, is considered to be the key mechanism in many hepatic pathologies. Therefore, polysaccharides and other types of phytochemicals with activities in ferroptosis regulation provide novel therapeutic strategies for ferroptosis-related liver diseases. This review summarizes our current understanding of the mechanisms of ferroptosis and liver injury and compelling preclinical evidence of natural bioactive polysaccharides and phytochemicals in treating liver disease.

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“…Mast cell-deficient animals have lower degrees of liver fibrosis. The effect of mast cells may be mediated through their stimulatory roles in the proliferation of cholangiocytes and in the further activation of HSCs (Meurer et al, 2020). Specific inhibition of mast cells may therefore be another target of intervention to prevent fibrosis.…”

Section: Molecular Mechanism Of Liver Fibrosis and Recent Clinical Trialsmentioning

confidence: 99%

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

et al. 2021

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Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic liver damage and leading to cirrhosis, liver cancer, and liver failure. To date, there is no effective and specific therapy for patients with hepatic fibrosis. As a result of their various advantages such as biocompatibility, imaging contrast ability, improved tissue penetration, and superparamagnetic properties, magnetic nanoparticles have a great potential for diagnosis and therapy in various liver diseases including fibrosis. In this review, we focus on the molecular mechanisms and important factors for hepatic fibrosis and on potential magnetic nanoparticles-based therapeutics. New strategies for the diagnosis of liver fibrosis are also discussed, with a summary of the challenges and perspectives in the translational application of magnetic nanoparticles from bench to bedside.

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Advances in the clinical use of collagen as biomarker of liver fibrosis

Cited by 12 publications

References 165 publications

Pathological Evaluation of Canine Hepatic Cirrhosis and Necro-inflammatory Activity

Pathological Evaluation of Canine Hepatic Cirrhosis and Necro-inflammatory Activity

The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

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