Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease

Kulkarni, Nilesh; Jain, Priti; Shindikar, Amol; Suryawanshi, Pravin; Thorat, Nanasaheb D.

doi:10.1016/j.carbpol.2022.119351

Cited by 79 publications

(31 citation statements)

References 166 publications

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“…Chitosan, as a natural polysaccharide, has played an important role in biomedicine with the advantages of excellent biodegradability and biosafety . Diverse types of drug-loaded micro-/nanoparticles based on chitosan are designed for targeted drug delivery, possessing the features of sustained drug release and pH responsiveness. − Researchers have explored the use of chitosan microparticles loaded with drugs to treat colorectal cancer, showing good therapeutic effects. , The emulsification cross-linking method was introduced to fabricate chitosan microparticles (CMs) to load the drug. The scanning electron microscopy (SEM) image of CMs is shown in Figure b.…”

Section: Resultsmentioning

confidence: 99%

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Chen

Zhang

Tian

et al. 2022

ACS Appl. Polym. Mater.

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Tremendous progress in applying small-scale magnetic robots for targeted drug delivery has sparked a growing interest among researchers. However, significant effort is needed to design and fabricate robots to meet the needs of clinical treatments, such as biocompatibility, biodegradation, and synergistic therapy. Here, we propose a multiscale magnetic hydrogel robot (MMHR) with a core–shell structure in which superparamagnetic nanoparticles and curcumin-loaded chitosan microparticles (CCMs) are encapsulated inside the core, while doxorubicin-loaded chitosan microparticles (DCMs) are embedded inside the shell. The core and shell of the MMHR are composed of pH-sensitive calcium alginate hydrogels that can alleviate the sudden release of drugs from CCMs and DCMs in gastric fluid. MMHRs can be precisely actuated to the target region through magnetic driving systems for further drug delivery. The experimental results demonstrate that the MMHR possesses superior obstacle-crossing ability and can successfully locomote on the surface of the intestine. Additionally, the co-delivery of doxorubicin and curcumin is realized through the different fabrication methods of CCMs and DCMs and shows excellent synergistic therapeutic effects against colon cancer cells. The powerful propulsion, good biocompatibility, and remarkable synergistic efficacy of the MMHR offer a promising route for active drug delivery through the gastrointestinal tract.

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Section: Resultsmentioning

confidence: 99%

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Chen

Zhang

Tian

et al. 2022

ACS Appl. Polym. Mater.

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“…67,68 Therefore, several researchers have been devoted to engineering suitable NPs as colon-targeted DDSs for IBD treatment in the past years. 69–71 In this part, several NP platforms as colon-targeted DDSs in the treatment of IBD will be particularly discussed.…”

Section: Np Systemsmentioning

confidence: 99%

“…86 Chitosan NPs are widely applied as colon-targeted DDSs in IBD treatment because of their good biocompatibility, desirable biodegradability, and strong muco-adhesiveness. 69,87,88 Moreover, chitosan NPs presenting a positively charged amino group (–NH 3+ ) can specifically interact with the negatively charged mucosal surface of the inflamed colon contributing to prolonged drug release, and enhanced colonic drug absorption. 89,90 However, chitosan is known for its solubility in acidic media, which may exhibit a premature release and/or burst release of the agents before reaching the colon.…”

Section: Np Systemsmentioning

confidence: 99%

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Yang

et al. 2022

J. Mater. Chem. B

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“…CS-based multiparticulate dosage forms, aimed at the colon delivery of drugs in the treatment of Inflammatory Bowel Disease, were recently reviewed [ 322 ]. CS-based conventional and unconventional colon-targeted delivery systems were recently reviewed [ 323 , 324 ]; however, the scientific production about such a subject is so broad and articulated, that you can continuously find new CS applications in this field.…”

Section: Chitosan-based Mucosal Drug Delivery Systemsmentioning

confidence: 99%

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

et al. 2022

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Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the pharmaceutical field, in the early 1990s, CS attracted great interest, which has constantly increased over the years, due to its several beneficial and favorable features, including large availability, biocompatibility, biodegradability, non-toxicity, simplicity of chemical modifications, mucoadhesion and permeation enhancer power, joined to its capability of forming films, hydrogels and micro- and nanoparticles. Moreover, its cationic character, which renders it unique among biodegradable polymers, is responsible for the ability of CS to strongly interact with different types of molecules and for its intrinsic antimicrobial, anti-inflammatory and hemostatic activities. However, its pH-dependent solubility and susceptibility to ions presence may represent serious drawbacks and require suitable strategies to be overcome. Presently, CS and its derivatives are widely investigated for a great variety of pharmaceutical applications, particularly in drug delivery. Among the alternative routes to overcome the problems related to the classic oral drug administration, the mucosal route is becoming the favorite non-invasive delivery pathway. This review aims to provide an updated overview of the applications of CS and its derivatives in novel formulations intended for different methods of mucosal drug delivery.

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Advances in the colon-targeted chitosan based multiunit drug delivery systems for the treatment of inflammatory bowel disease

Cited by 79 publications

References 166 publications

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Multiscale Magnetic Hydrogel Robot with a Core–Shell Structure for Active Targeted Delivery

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

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