Advances in the Hyphenation of Flow Analysis Techniques with Liquid Separations for Pharmaceutical Analysis

Abstract

This commentary critically discusses the main advances in the field of flow analysis techniques hyphenated with liquid separations for pharmaceutical analysis over the last 15 years. Flow analysis techniques provide a convenient way to perform chemical assays with significant benefits in terms of rapidity, simplicity and cost of instrumentation, economy, precision, versatility in sample handling and potential for automation. The first-generation flow injection analysis (FIA), developed in the 1970's, has been supplemented by a host of second-generation and third-generation flow methods developed in the 1990's and 2000's such as sequential injection analysis (SIA) and multi-syringe flow injection analysis (MSFIA) [1]. However, the main drawback of these techniques is their limited ability to simultaneously determine several analytes.

Programmable Low-Pressure Chromatographic Sub-90 s Assay of Parabens in Cosmetics with Post-Column Chemiluminescence Detection

“…Different methodologies, mainly based on liquid chromatography, have been proposed for the separation and the determination of parabens in cosmetics [11][12][13]. Over the last few years, low-pressure separation approaches have been developed and applied to the separation and determination of many organic compounds [14][15][16][17]. Low-pressure techniques utilize simpler and less expensive components (pumps, valves) than the highpressure ones necessary for HPLC.…”

Upcoming New Dimension in Drug Analysis Methods

“…The methods of partition and evaluation of the atomic elements assume a signi icant job in pharmaceutical investigations. In the wake of thinking about the mechanical headways, preferences and the constraint of hyphenated approaches, Economou [3] has underlined that luid partitionbased hyphenation of stream investigation ills in as corresponding to standard luid chromatography and has a massive degree in pharmaceutical examination with ability to decide a huge number of pharmaceuticals including the application for low to medium weight detachments and advancement of slope elution convention just as online example pretreatment. [4] Massive importance in creating, adjusting, enhancing and approval of better explanatory systems and approaches having pertinence to nasal shower based treatment; structuring and creating exact medication analogues for malignant growth treatment just as detachment of new pharmaceutical analytes which present signi icant systematic dif iculties [5].…”

New Dimensions of Pharmaceutical Analysis

“…The techniques of separation and quantification of the molecular entities play major role in pharmaceutical analyses. After deliberating about the technological advancements, advantages and the limitation of hyphenated approaches, Economou [3] has emphasized that liquid separation based hyphenation of flow analysis serves as complementary to customary liquid chromatography and has immense scope in pharmaceutical analysis with capacity to determine large number of pharmaceuticals including application for low to medium pressure separations and development of gradient elution protocol as well as online sample pretreatment.…”