Advances in the mechanisms of Hibiscus sabdariffa L. on hypertension

Liu, Hua; Liang, Ze-Ming; Li, Rui-ting; Yu, Yigang

doi:10.1051/e3sconf/202014501039

Cited by 4 publications

(6 citation statements)

References 46 publications

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“…The application of this plant in traditional medicine has been supported by previous scientific research for the treatment of hypertension (Al Disi et al, 2016;Al-anbaki et al, 2019;Herrera-Arellano et al, 2016;Liu et al, 2020), inflammation (Garbi et al, 2017), type-2 diabetes (Adeyemi & Adewole, 2019;Ndarubu et al, 2019). In addition, scientific evidence has also shown that it possesses hepatoprotective (Bhavana et al, 2017), nephroprotective (Al-Qahtani et al, 2017;Anwar Ibrahim & Noman Albadani, 2014), as well as cancer preventive activities (Fithrotunnisa et al, 2020;Malacrida et al, 2016& Su et al, 2018.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 84%

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Elegbeleye¹,

Krishnamoorthy

Bamidele

et al. 2022

Journal of Food Biochemistry

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The rural communities of the sub‐Sahara regions in Africa are rich in diverse indigenous culinary knowledge and foods, food crops, and condiments such as roots/tubers, cereal, legumes/pulses, locust beans, and green leafy vegetables. These food crops are rich in micronutrients and phytochemicals, which have the potentials to address hidden hunger as well as promote health when consumed. Some examples of these are fermented foods such as ogi and plants such as Vernonia amygdalina (bitter leaf), Zingiber officinales (garlic), Hibiscus sabdariffa (Roselle), and condiments. Food crops from West Africa contain numerous bioactive substances such as saponins, alkaloids, tannins, phenolics, flavonoids, and monoterpenoid chemicals among others. These bioresources have proven biological and pharmacological activities due to diverse mechanisms of action such as immunomodulatory, anti‐inflammatory, antipyretic, and antioxidant activities which made them suitable as candidates for nutraceuticals and pharma foods. This review seeks to explore the different processes such as fermentation applied during food preparation and food crops of West‐African origin with health‐promoting benefits. The different bioactive compounds present in such food or food crops are discussed extensively as well as the diverse application, especially regarding respiratory diseases. Practical applications The plants and herbs summarized here are more easily accessible and affordable by therapists and others having a passion for promising medicinal properties of African‐origin plants.The mechanisms and unique metabolic potentials of African food crops discussed in this article will promote their applicability as a template molecule for novel drug discoveries in treatment strategies for emerging diseases. This compilation of antiviral plants will help clinicians and researchers bring new preventive strategies in combating COVID‐19 like viral diseases, ultimately saving millions of affected people.

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Section: Ta B L E 1 (Continued)mentioning

confidence: 84%

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Elegbeleye¹,

Krishnamoorthy

Bamidele

et al. 2022

Journal of Food Biochemistry

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“…1 Several drugs used for treating hypertension belong to the angiotensin-converting enzyme (ACE) inhibitor class, which work by inhibiting the conversion of angiotensin-I to angiotensin-II, a vasopressor that triggers an increase in blood pressure. 2,3 However, antihypertensive drugs have limitations because they must be adjusted to the patient's health condition, especially those with contraindications. 1 In addition, the long-term use of synthetic drugs can cause undesired side effects, such as hypersensitivity reactions, itching, hypotension, and upper respiratory tract infections.…”

Section: Introductionmentioning

confidence: 99%

“…32 One of the physiological properties of the phytochemicals contained in H. sabdariffa and C. sativus is their ability to inhibit ACE. 2,7,33 In several studies, observations of ACE-inhibitory activity were carried out by initially extracting the plants in the form of decoction/infusion, 22,23 but the doses used were still varied, so the therapeutic effects observed were still inconsistent. 34 Furthermore, no previous study has directly measured the ACE inhibitory activities of H. sabdariffa and C. sativus from their infusions.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition and Inhibitory Activities of Hibiscus sabdariffa and Cucumis sativus Infusions Against Angiotensin-Converting Enzyme

2023

TJNPR

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Hibiscus sabdariffa and Cucumis sativus are often used in ethnomedicinal practice for treating several health conditions, including hypertension. The present study aimed to investigate the in vitro inhibitory activities of H. sabdariffa and C. sativus against angiotensin-converting enzyme (ACE) and their phytochemical properties directly from their infusions. Each infusion was prepared with a concentration of 10, 20, and 30 grams of plant material in 300 ml of hot distilled water. Combinations of both plants were also prepared in 1:1, 2:1, and 1:2 ratios. The inhibitory activities were determined by the colorimetric method. The results showed that the highest inhibition rates of H. sabdariffa and C. sativus infusions were 88.741±0.001% and 92.180±0.001%, respectively. Meanwhile, the highest inhibition rate of the combination infusion was obtained from the ratio of H. sabdariffa: C. sativus (1:2), which was 96.062±0.001%, although this result was still below the inhibitory activity of Captopril (97.393±0.001%). The phytochemical screening results indicated that H. sabdariffa infusions contain saponins and tannins, and C. sativus infusions contain alkaloids, saponins, and terpenoids. This study concluded that the infusion with the ratio of H. sabdariffa: C. sativus (1:2) demonstrated the strongest inhibitory activity against ACE and, therefore, could potentially be utilized as a functional drink for managing hypertension.

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“…Pharmacological studies have demonstrated that the anthocyanins from roselle, specially cyanidin‐3‐sambubioside and delphinidin‐3‐sambubioside, are involved in the majority of the blood pressure‐lowering mechanisms (Hopkins et al, 2013; Liu et al, 2020). The beneficial effect of roselle extracts on blood pressure reduction in normotensives and hypertensives has been well documented in both human and animal studies (Herrera‐Arellano et al, 2007; Hopkins et al, 2013; Inuwa et al, 2012; McKay et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacological studies have demonstrated that the anthocyanins from roselle, specially cyanidin-3-sambubioside and delphinidin-3-sambubioside, are involved in the majority of the blood pressure-lowering mechanisms (Hopkins et al, 2013;Liu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Improvement on blood pressure and skin using roselle drink: A clinical trial

Chiu

Liao

Shen

et al. 2022

Journal of Food Biochemistry

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Roselle (Hibiscus sabdariffa L.) is an increasingly attractive plant for its health and pharmaceutical, beverage, and cosmetic applications. The purpose of this study was to investigate the clinical effects of roselle drink on antioxidant activity, blood pressure, and skin condition. Roselle drink used in this study contained rich phenolics (1.96 g of gallic acid equivalent/100 ml) and anthocyanins (1.65 g of cyanidin‐3‐glucoside equivalent/100 ml). In a randomized, cross‐over, double‐blind, placebo‐controlled clinical study, 39 healthy adults received drank 200 ml of roselle drink or placebo‐control drink for 6 months. A significant reduction in the blood pressure was observed in the roselle drink treated group when compared with preintervention values. After 6 months of treatment with roselle drink, serum phenolics contents, the levels of Trolox equivalent antioxidant capacity (TEAC), glutathione, superoxide dismutase (SOD), glucose‐6‐phosphate dehydrogenase (G‐6‐PDH), glutathione peroxidase (GSH‐Px), and glutathione reductase (GSH‐Rd) were significantly increased in healthy subjects. However, a significant increment in skin redness and skin moisture was observed in the facial skin of roselle drink‐treated participants. Oral administration of roselle drink for 6 months significantly lowered the blood pressure, improved antioxidation level, and positively regulated skin redness as well as moisture. Phenolics and anthocyanins in roselle could be the major potential contributors to such health effects. Practical applications Roselle is a typical plant. Continuous administration of roselle drink clearly improved antioxidation levels, reduced blood pressure and positively regulated skin redness and moisture. Phenloics and anthocyanins in roselle could be the major potentila contributors of such health benefits.

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Advances in the mechanisms of Hibiscus sabdariffa L. on hypertension

Cited by 4 publications

References 46 publications

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Health‐promoting foods and food crops ofWest‐Africaorigin: The bioactive compounds and immunomodulating potential

Phytochemical Composition and Inhibitory Activities of Hibiscus sabdariffa and Cucumis sativus Infusions Against Angiotensin-Converting Enzyme

Improvement on blood pressure and skin using roselle drink: A clinical trial

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