Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

Abstract

Chronic diabetic wounds are one of the main complications of diabetes, manifested by persistent inflammation, decreased epithelialization motility, and impaired wound healing. This will not only lead to the repeated hospitalization of patients, but also bear expensive hospitalization costs. In severe cases, it can lead to amputation, sepsis or death. Electrospun nanofibers membranes have the characteristics of high porosity, high specific surface area, and easy functionalization of structure, so they can be used as a safe and effective platform in the treatment of diabetic wounds and have great application potential. This article briefly reviewed the pathogenesis of chronic diabetic wounds and the types of dressings commonly used, and then reviewed the development of electrospinning technology in recent years and the advantages of electrospun nanofibers in the treatment of diabetic wounds. Finally, the reports of different types of nanofiber dressings on diabetic wounds are summarized, and the method of using multi-drug combination therapy in diabetic wounds is emphasized, which provides new ideas for the effective treatment of diabetic wounds.

Electrospun Polycaprolactone/Chitosan Nanofibers Containing Cordia myxa Fruit Extract as Potential Biocompatible Antibacterial Wound Dressings

“…Electrospinning was utilized to prepare PCL/CH nanofibrous scaffolds in the current study, where the CMF extract was immobilized into the created nanofibers. In spite of the fact that medicinal CMF extract has notable wound healing and antibacterial actions, it is preferable to improve them via immobilizing the extract on the nanofibrous surface of a scaffolding [ 31 ]. Electrospinning polymer nanofibers of PCL/CH containing a varied quantity of CMF extract was performed according to the criteria outlined in the methods section.…”

Recent Progress of Electrospun Herbal Medicine Nanofibers

“…With the rapid development of technology, electrospinning is improved and developed in three directions: (1) From a single fluid process to coaxial [110,111], triaxial [112,113], side by side [114,115] and the combination of multi-fluid processes [116][117][118], improve the practical functions of the designed complex nanostructures; (2) the scale-up fabrication of nanofibers for realization of their medical and material applications [77,119]; and (3) direct functional application of nanofibers [120].…”

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

“…Hydrogels 20–30 nm in size (“nanogels”) are capable of incorporating hydrophobic drugs into the core and delivering them to their destination, providing their prolonged release. In particular, hydrogel delivery systems for enzymes [ 6 ], proteins [ 7 ], antibiotics [ 8 , 9 , 10 , 11 ], adenoviruses [ 12 ], anticancer drugs, for example, doxorubicin [ 13 , 14 , 15 ], paclitaxel [ 16 ], 5-fluorouracil [ 17 , 18 , 19 ], kaempferol [ 20 ], vincristine [ 21 ], oxaliplatin [ 22 ], cyclophosphamide [ 23 ], carmustine and curcumin [ 24 ], drugs for the treatment of skin diseases [ 25 , 26 , 27 ], anesthetics for the treatment of acute postoperative pain [ 28 ], antimicrobial silver nanoparticles and quantum dots for wound healing [ 29 , 30 ] are known and studied currently. The rate of release of these mentioned drugs from hydrogels is affected by the degree of cross-linking and the degree of swelling of the hydrogels.…”