Advances in the Relationship between Respiratory Viruses and Asthma

Romero-Tapia, Sergio; Guzmán Priego, Crystell; Del-Río-Navarro, Blanca; Sánchez-Solis, Manuel

doi:10.3390/jcm12175501

Cited by 11 publications

(2 citation statements)

References 102 publications

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“…56 It is to be noted that these clinical conditions usually follow acute viral RIs in children. 57 Therefore, this literature evidences confirmed that these products could effectively and safely prevent RRIs.…”

Section: Intergroup Analysismentioning

confidence: 58%

Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray

Tosca,

Varricchio,

Schiavetti

et al. 2024

Allergol Immunopathol

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Background: Preschoolers frequently have respiratory infections (RIs) that, in turn, may cause wheezing in some subjects. Type 2 polarization may favor increased susceptibility to RIs and associated wheezing. Non-pharmacological remedies are garnering increasing interest as possible add-on therapies. The present preliminary study investigated the efficacy and safety of a new multicomponent nasal spray in preschoolers with frequent RIs and associated wheezing. Methods: Some preschoolers with these characteristics randomly took this product, containing lactoferrin, dipotassium glycyrrhizinate, carboxymethyl-beta-glucan, vitamin C, and vitamin D3 (Saflovir), two sprays per nostril twice daily for three months. Other children were randomly treated only with standard therapy. Outcomes included the number of RIs and wheezing episodes, medications use, and symptoms' severity. Results: preschoolers treated add-on with this multicomponent product experienced fewer RIs and used fewer b2-agonists than untreated children (p=0.01 and 0.029, respectively). Conclusions: This preliminary experience demonstrated that a multicomponent product, add-on administered as a nasal spray, could reduce the incidence of respiratory infections and the use of symptomatic drugs for relieving wheezing in children.

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Section: Intergroup Analysismentioning

confidence: 58%

Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray

Tosca,

Varricchio,

Schiavetti

et al. 2024

Allergol Immunopathol

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show abstract

“…A recent study indicated that the approximately 15%of 5-year current asthma cases could be prevented by avoiding RSV infection during infancy 21 . Additionally, recurrent infections with other viruses, such as rhinovirus, in uenza virus, adenovirus, and can lead to the occurrence of asthma 22 . For the infection of the novel coronavirus, the initial focus has been on Long COVID syndrome.…”

Section: Resultsmentioning

confidence: 99%

Causal relationship between COVID-19 and the risk of asthma: A Mendelian Randomisation study

Chen,

Li,

Shi

et al. 2024

Preprint

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Background Existing research has focused on new-onset asthma and viral infections, particularly respiratory syncytial virus (RSV). However, studies on whether COVID-19 can induce asthma are limited. Methods We performed bidirectional two-sample Mendelian Randomization (MR) to assess the potential causal relationship between COVID-19 and asthma using genome-wide association study (GWAS) summary data obtained from the COVID-19 Host Genetic Initiative GWAS Meta-analysis Round 5 (release date: 18 January 2021). Several methods (random-effects inverse variance weighted, weighted median, MR-Egger regression, and MR-PRESSO) were used to ensure the robustness of the causal effects. Heterogeneity was measured using Cochran's Q value. Horizontal pleiotropy was evaluated using MR-Egger regression and leave-one-out analyses. Results We observed a significant causal association between COVID-19 hospitalisation and asthma (odds ratio (OR) = 1.042, 95% Confidence Interval (CI) = 1.004–1.081, p = 0.031), indicating a significantly increased risk of COVID-19 hospitalisation associated with asthma. However, no statistically significant causal relationships were observed for COVID-19 susceptibility (OR = 1.023, 95% CI = 0.931–1.124, p = 0.637), COVID-19 severity (OR = 1.006, 95% CI = 0.978–1.035, p = 0.669), and asthma. Conclusions COVID-19 can trigger the onset of asthma. Individuals experiencing prolonged coughing, chest tightness, or difficulty in breathing long after recovery from COVID-19 should remain vigilant about the possibility of developing asthma.

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Influenza, SARS-CoV-2, and Their Impact on Chronic Lung Diseases and Fibrosis

Soni,

Antonescu,

et al. 2024

The American Journal of Pathology

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Advances in the Relationship between Respiratory Viruses and Asthma

Cited by 11 publications

References 102 publications

Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray

Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray

Causal relationship between COVID-19 and the risk of asthma: A Mendelian Randomisation study

Influenza, SARS-CoV-2, and Their Impact on Chronic Lung Diseases and Fibrosis

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