Advances in the treatment of chronic wounds: a patent review

Koppen, Chris J. van; Hartmann, Rolf W.

doi:10.1517/13543776.2015.1045879

Cited by 58 publications

(36 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Defective wound healing affects millions of people in the Western World and is a strong burden to patients and healthcare systems . Although there is a plethora of wound therapies available, challenges remain in the treatment of problematic wounds . Non‐healing wounds are known to display an imbalance in redox processes and inflammation, ultimately disturbing the sequence of events necessary for healing.…”

Section: Introductionmentioning

confidence: 99%

A cold plasma jet accelerates wound healing in a murine model of full‐thickness skin wounds

Schmidt

Bekeschus

Wende

et al. 2017

Experimental Dermatology

203

140

View full text Add to dashboard Cite

Cold plasma has been successfully applied in several fields of medicine that require, for example, pathogen inactivation, implant functionalization or alteration of cellular activity. Previous studies have provided evidence that plasma supports the healing of wounds owing to its beneficial mixtures of reactive species and modulation of inflammation in cells and tissues. To investigate the wound healing activity of an atmospheric pressure plasma jet in vivo, we examined the cold plasma's efficacy on dermal regeneration in a murine model of dermal full-thickness ear wound. Over 14 days, female mice received daily plasma treatment. Quantitative analysis by transmitted light microscopy demonstrated a significantly accelerated wound re-epithelialization at days 3-9 in comparison with untreated controls. In vitro, cold plasma altered keratinocyte and fibroblast migration, while both cell types showed significant stimulation resulting in accelerated closure of gaps in scratch assays. This plasma effect correlated with the downregulation of the gap junctional protein connexin 43 which is thought to be important in the regulation of wound healing. In addition, plasma induced profound changes in adherence junctions and cytoskeletal dynamics as shown by downregulation of E-cadherin and several integrins as well as actin reorganization. Our results theorize cold plasma to be a beneficial treatment option supplementing existing wound therapies.

show abstract

Section: Introductionmentioning

confidence: 99%

A cold plasma jet accelerates wound healing in a murine model of full‐thickness skin wounds

Schmidt

Bekeschus

Wende

et al. 2017

Experimental Dermatology

203

140

View full text Add to dashboard Cite

show abstract

“…As a result, there is urgent need of novel therapies for these conditions. 22 Today, researchers are interested to study traditional systems of medicine to find remedies for the current medical issues. One of these systems is traditional Persian medicine, which is still being practiced in Iran.…”

Section: Discussionmentioning

confidence: 99%

An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

Hosseinkhani

Falahatzadeh

Raoofi

et al. 2016

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

Research on wound healing agents is a developing area in biomedical sciences. Traditional Persian medicine is one of holistic systems of medicine providing valuable information on natural remedies. To collect the evidences for wound-healing medicaments from traditional Persian medicine sources, 5 main pharmaceutical manuscripts in addition to related contemporary reports from Scopus, PubMed, and ScienceDirect were studied. The underlying mechanisms were also saved and discussed. Totally, 65 herbs used in traditional Persian medicine for their wound healing properties was identified. Related anti-inflammatory, antioxidant, antimicrobial, and wound-healing activities of those remedies were studied. Forty remedies had at least one of those properties and 10 of the filtered plants possessed all effects. The medicinal plants used in wound healing treatment in traditional Persian medicine could be a good topic for further in vivo and clinical research. This might lead to development of effective products for wound treatment.

show abstract

“…45 Additionally, failed reepithelialization may perpetuate these processes. 46 Chronic wounds demonstrate a pathological level of underhealing. The use of stem cells in addressing these lesions is geared toward restoring the wound's ability to heal, either by supplanting ineffective healing mechanisms or by augmenting muted physiological processes.…”

Section: Interactions Between Stem Cells and Chronic Wounds Chronic Wmentioning

confidence: 99%

Stem cells and chronic wound healing: state of the art

Leavitt¹,

Hu²,

Barnes³

et al. 2016

CWCMR

View full text Add to dashboard Cite

Currently available treatments for chronic wounds are inadequate. A clearly effective therapy does not exist, and treatment is often supportive. This is largely because the cellular and molecular processes underlying failure of wound repair are still poorly understood. With an increase in comorbidities, such as diabetes and vascular disease, as well as an aging population, the incidence of these intractable wounds is expected to rise. As such, chronic wounds, which are already costly, are rapidly growing as a tremendous burden to the health-care system. Stem cells have garnered much interest as a therapy for chronic wounds due to their inherent ability to differentiate into multiple lineages and promote regeneration. Herein, we discuss the types of stem cells used for chronic wound therapy, as well as the proposed means by which they do so. In particular, we highlight mesenchymal stem cells (including adipose-derived stem cells), endothelial progenitor cells, and induced pluripotent stem cells. We include the results of recent in vitro and in vivo studies in both animal models and human clinical trials. Finally, we discuss the current studies to improve stem cell therapies and the limitations of stem cell-based therapeutics. Stem cells promise improved therapies for healing chronic wounds, but further studies that are well-designed with standardized protocols are necessary for fruition.

show abstract

Advances in the treatment of chronic wounds: a patent review

Cited by 58 publications

References 36 publications

A cold plasma jet accelerates wound healing in a murine model of full‐thickness skin wounds

A cold plasma jet accelerates wound healing in a murine model of full‐thickness skin wounds

An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

Stem cells and chronic wound healing: state of the art

Contact Info

Product

Resources

About