Advances in the treatment of central serous chorioretinopathy

Abstract

Central serous chorioretinopathy is a disease that is partly understood. Novel advancements have led to further understanding of the disease, and have identified choroidal dysfunction as the principal element in CSCR development. New imaging tools have aided in better monitoring disease response to various treatment models. Enhanced depth imaging optical coherence tomography, in particular, has helped in observing choroidal thickness changes after various treatment models. To date, photodynamic therapy and focal laser remain the main stay of treatment. More understanding of disease pathophysiology in the future will help in determining the drug of choice and the best management option for such cases.

Ranibizumab in the Treatment of Chronic Central Serous Chorio Retinopathy

“…However, those who do not resolve spontaneously may develop permanent visual impairment because of pigment epithelial and photoreceptor damage [6]. Most clinicians prefer to observe these patients for three months before considering any treatment options because most cases recover spontaneously [7][8][9]. Infrequently, neurosensory retinal detachment persists and leads to RPE and photoreceptor damage.…”

Comparison of optical coherence tomography findings in males and females with acute central serous chorioretinopathy

“…It has a benign and self-limiting nature, with a long-term recurrence rate of 30%. CSCR usually occur in males in 20-50 years [1][2][3][4][5][6].…”

“…Although the pathogenesis of disease is well unknown, it has been considered that focal RPE defect or choroidal lobular ischemia and choroidal venous congestion may be played in the main role [5][6][7][8]. Recent studies have demonstrated that the CSC is associated with psychological stress, type A personality, glucocorticoid treatment, endogenous hypercortisolism like Cushing's syndrome, systemic hypertension, and pregnancy [1][2][3][4][5][6][7][8][9].…”

“…Recent studies have demonstrated that the CSC is associated with psychological stress, type A personality, glucocorticoid treatment, endogenous hypercortisolism like Cushing's syndrome, systemic hypertension, and pregnancy [1][2][3][4][5][6][7][8][9].…”

Effect of half adult dose of oral Rifampicin (300mg) in patientswith idiopathic central serous chorioretinopathy

“…However 50% of the patients have recurrences and 15-20% progress to chronic form which has relatively poor visual outcome 12. Various treatment modalities such as standard laser photocoagulation, micro-pulse diode laser photocoagulation, trans-pupillary thermotherapy (TTT), photodynamic therapy (PDT)and multiple anti-corticosteroids agents have been proposed for the treatment of CSCR 13. A recent study documented mineralocorticoid receptors in choroidal tissue, and hypothesized that glucocorticoids activate mineralocorticoid receptors and may cause or aggravate CSCR manifestations [Zhao M et al 2012] 14.…”