Advances in the use of calcium silicate-based materials in bone tissue engineering

Liu, Zhihua; He, Xiaoyu; Chen, Shupeng; Yu, Haiming

doi:10.1016/j.ceramint.2023.03.063

Cited by 25 publications

(7 citation statements)

References 122 publications

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“…Si is extremely important in the calcification of bone, specifically in the metabolic process. Furthermore, Si can help to enhance bone density and inhibit osteoporosis [13][14][15][16]. In vitro cell culture studies have shown that CaSi-based materials can support the attachment, proliferation, and differentiation of human bone mesenchymal stem cells (hMSC).…”

Section: Introductionmentioning

confidence: 99%

Whey Protein Isolate/Calcium Silicate Hydrogels for Bone Tissue Engineering Applications—Preliminary In Vitro Evaluation

Ivory-Cousins,

Nurzynska,

Klimek

et al. 2023

Materials

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Whey protein isolate (WPI) hydrogels are attractive biomaterials for application in bone repair and regeneration. However, their main limitation is low mechanical strength. Therefore, to improve these properties, the incorporation of ceramic phases into hydrogel matrices is currently being performed. In this study, novel whey protein isolate/calcium silicate (WPI/CaSiO3) hydrogel biomaterials were prepared with varying concentrations of a ceramic phase (CaSiO3). The aim of this study was to investigate the effect of the introduction of CaSiO3 to a WPI hydrogel matrix on its physicochemical, mechanical, and biological properties. Our Fourier Transform Infrared Spectroscopy results showed that CaSiO3 was successfully incorporated into the WPI hydrogel matrix to create composite biomaterials. Swelling tests indicated that the addition of 5% (w/v) CaSiO3 caused greater swelling compared to biomaterials without CaSiO3 and ultimate compressive strength and strain at break. Cell culture experiments demonstrated that WPI hydrogel biomaterials enriched with CaSiO3 demonstrated superior cytocompatibility in vitro compared to the control hydrogel biomaterials without CaSiO3. Thus, this study revealed that the addition of CaSiO3 to WPI-based hydrogel biomaterials renders them more promising for bone tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Whey Protein Isolate/Calcium Silicate Hydrogels for Bone Tissue Engineering Applications—Preliminary In Vitro Evaluation

Ivory-Cousins,

Nurzynska,

Klimek

et al. 2023

Materials

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“…In comparison, calcium silicate bioceramic materials possess better mechanical properties than calcium phosphate bioceramic materials and induce the deposition of a calcium-phosphate layer on the scaffold surface, demonstrating excellent mineralization capability. 26 Nevertheless, calcium silicate bioceramic scaffold degrades relatively quickly in the body, potentially leading to an increased pH around the scaffold, which might be detrimental to cell growth. Bioactive glass primarily comprises SiO 2 , Na 2 O, CaO, P 2 O 5 , and so on, which exhibits excellent bone generation and guiding properties, fostering strong integration in both bone and soft tissues.…”

Section: Bone Tissue Engineering Scaffoldmentioning

confidence: 99%

Construction of antibacterial bone implants and their application in bone regeneration

Feng,

He,

et al. 2024

Mater. Horiz.

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“…In addition, calcium silicate's osteoinductivity and bone ingrowth properties remain inadequate. Owing to these limitations, researchers have endeavored to improve calcium silicate's mechanical and osteogenic properties by adding various materials [22]. So, the novelty of this work is to evaluate if the addition of protein material to calcium silicate affects the performance of calcium silicate as a coating material; therefore, this study aims to investigate some properties of various concentrations of zein and calcium silicate composite coating (with different concentrations of 10% : 90%, 20% : 80%, and 30% : 70% of zein : calcium silicate) on PEEK dental implants.…”

Section: Introductionmentioning

confidence: 99%

Studying and Characterization of Coating of Zein–CaSiO3 Composite on Polyetheretherketone Implant Material

Abdulrazzaq,

Ismael Hamad

2024

International Journal of Dentistry

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Material-coated implants are placed in the bone and play an essential role in bone regeneration and rapid healing around implants. Polymeric matrix reinforced with ceramic materials is a promising composite material for coating implants. This study aims to determine the effect of mixing various concentrations of zein with CaSiO3 on polyetheretherketone (PEEK) as implant material. The coating was performed using the electrospray method. PEEK disks were used as a control group. The coated disks with different concentrations of zein–CaSiO3 (Group 1: 10% wt, 90% wt), (Group 2: 20% wt, 80% wt), and (Group 3%: 30% wt, 70% wt) were the experimental group. Each group was characterized by atomic force microscopy, field emission scanning electron microscope, Fourier-transform infrared spectroscopy, water contact angle, and adhesion strength. The lowest water contact angle was obtained for Group 1: 10% wt and 90% wt were (26.64° and 27.13°, respectively), and increasing amounts of zein in comparison to quantities of CaSiO3 resulted in increased adhesion strength of the composite material to the substrate. The current study suggested that the higher amount of zein compared to the amount of CaSiO3 mixture coating is achieved by electrospraying, a favorable candidate for coating implants compared to uncoated and coated disks with low concentrations of zein compared to concentrations of CaSiO3.

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Advances in the use of calcium silicate-based materials in bone tissue engineering

Cited by 25 publications

References 122 publications

Whey Protein Isolate/Calcium Silicate Hydrogels for Bone Tissue Engineering Applications—Preliminary In Vitro Evaluation

Whey Protein Isolate/Calcium Silicate Hydrogels for Bone Tissue Engineering Applications—Preliminary In Vitro Evaluation

Construction of antibacterial bone implants and their application in bone regeneration

Studying and Characterization of Coating of Zein–CaSiO3 Composite on Polyetheretherketone Implant Material

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