Advances in tissue engineering of nanocellulose-based scaffolds: A review

Luo, Huize; Cha, Ruitao; Li, Juanjuan; Hao, Wenshuai; Zhang, Yan; Zhou, Fengshan

doi:10.1016/j.carbpol.2019.115144

Cited by 186 publications

(109 citation statements)

References 140 publications

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“…To conclude the natural polymer section, cellulose represents another interesting material mainly obtained from different natural source such as bacteria, tunicates, and plants. Constituted of a polysaccharide macromolecule with β-(1,4) glycosidic bonds, it is characterized by hydrophilicity, cytocompatibility, bioactivity and optical transparency that make it suitable in several medical applications, such as skin tissue repair, cortical implants, drug delivery, vascular graft and medical implants [59,60]. In particular, in the bone tissue field, it is widely used due to its tunability in terms of chemical, physical, and mechanical properties [38,59].…”

Section: Natural Polymersmentioning

confidence: 99%

“…Constituted of a polysaccharide macromolecule with β-(1,4) glycosidic bonds, it is characterized by hydrophilicity, cytocompatibility, bioactivity and optical transparency that make it suitable in several medical applications, such as skin tissue repair, cortical implants, drug delivery, vascular graft and medical implants [59,60]. In particular, in the bone tissue field, it is widely used due to its tunability in terms of chemical, physical, and mechanical properties [38,59]. Cellulose applications range from membrane, scaffold bulk material, coatings, nanofibers, films, and nanocrystals that lead the research in developing new technologies strategies [59,61,110].…”

Section: Natural Polymersmentioning

confidence: 99%

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Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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Bone tissue is the structural component of the body, which allows locomotion, protects vital internal organs, and provides the maintenance of mineral homeostasis. Several bone-related pathologies generate critical-size bone defects that our organism is not able to heal spontaneously and require a therapeutic action. Conventional therapies span from pharmacological to interventional methodologies, all of them characterized by several drawbacks. To circumvent these effects, tissue engineering and regenerative medicine are innovative and promising approaches that exploit the capability of bone progenitors, especially mesenchymal stem cells, to differentiate into functional bone cells. So far, several materials have been tested in order to guarantee the specific requirements for bone tissue regeneration, ranging from the material biocompatibility to the ideal 3D bone-like architectural structure. In this review, we analyse the state-of-the-art of the most widespread polymeric scaffold materials and their application in in vitro and in vivo models, in order to evaluate their usability in the field of bone tissue engineering. Here, we will present several adopted strategies in scaffold production, from the different combination of materials, to chemical factor inclusion, embedding of cells, and manufacturing technology improvement.

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Section: Natural Polymersmentioning

confidence: 99%

Section: Natural Polymersmentioning

confidence: 99%

Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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“…Among possible natural-derived polymers used for the production of hydrogels for biomedical applications, cellulose nanofibers (CNFs) have emerged as an outstanding alternative, thanks to the high availability, low cost and good biocompatibility of cellulose [16][17][18][19][20]. A suitable method for the preparation of CNFs is based on the regioselective oxidation of the primary hydroxyls of cellulose to corresponding carboxylic groups, catalyzed by 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) in the presence of an NaBr/NaClO oxidizing system.…”

Section: Introductionmentioning

confidence: 99%

TEMPO-Nanocellulose/Ca2+ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility

et al. 2020

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Stable hydrogels with tunable rheological properties were prepared by adding Ca2+ ions to aqueous dispersions of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)-oxidized and ultra-sonicated cellulose nanofibers (TOUS-CNFs). The gelation occurred by interaction among polyvalent cations and the carboxylic units introduced on TOUS-CNFs during the oxidation process. Both dynamic viscosity values and pseudoplastic rheological behaviour increased by increasing the Ca2+ concentration, confirming the cross-linking action of the bivalent cation. The hydrogels were proved to be suitable controlled release systems by measuring the diffusion coefficient of a drug model (ibuprofen, IB) by high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy. IB was used both as free molecule and as a 1:1 pre-formed complex with β-cyclodextrin (IB/β-CD), showing in this latter case a lower diffusion coefficient. Finally, the cytocompatibility of the TOUS-CNFs/Ca2+ hydrogels was demonstrated in vitro by indirect and direct tests conducted on a L929 murine fibroblast cell line, achieving a percentage number of viable cells after 7 days higher than 70%.

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“…The increased demand for high-performance materials with tailored mechanical and physical properties has elevated the nanocellulose status to one of the most attractive renewable materials for advanced medical applications. Nanocellulose is a considered to be a new generation of nanomaterials that combines important cellulose properties, including high specific strength, hydrophilicity, low density, flexibility and chemical inertness, with the ability to be chemically modified to incorporate specific features at the nanoscale [120,121]. In biomedicine, its exceptional water-retention capacity and large surface area that are associated with enhanced cell attachment, proliferation, and migration with no reports of toxic responses, has increased its desirability for a variety of uses that include packages, membranes for hemodialysis, vascular grafts, drug delivery systems, wound dressings, and tissue engineering strategies [122][123][124].…”

Section: Nanocellulosementioning

confidence: 99%

“…Nanocelluloses can be classified in three main categories: (1) cellulose nanofibers (CNFs), also known as microfibrillated cellulose (MFC), and nanofibrillated cellulose (NFC); (2) cellulose nanocrystals (CNCs), also designated by nanocrystalline cellulose (NCC) or cellulose nanowhiskers (CNWs); and, (3) BC or also named bacterial nanocellulose (BNC) [121]. The major difference between the CNFs and CNCs lies in their dimensions and crystalline structure.…”

Section: Nanocellulosementioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

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Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

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Advances in tissue engineering of nanocellulose-based scaffolds: A review

Cited by 186 publications

References 140 publications

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Natural and Synthetic Polymers for Bone Scaffolds Optimization

TEMPO-Nanocellulose/Ca2+ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

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