Advances of bacteria-based delivery systems for modulating tumor microenvironment

Cloaking Mesoporous Polydopamine with Bacterial Membrane Vesicles to Amplify Local and Systemic Antitumor Immunity

“…Many bacterial strains have since been tested on animal models and showed preferential tumor-targeting and good tumor eradication effects, several of which have been developed for clinical trials . Among them, VNP20009 was engineered from the Salmonella Typhimurium strain 14028S by knocking out msbB , purI genes and has advanced to clinical stages, while there were still potential biosafety hazards in using live bacteria . In this study, we leveraged the membrane debris from the attenuated Salmonella strain, which automatically assembled into DMVs, thus successfully reducing the live bacterial virulence and increasing the systemic safety.…”

“…62 Among them, VNP20009 was engineered from the Salmonella Typhimurium strain 14028S by knocking out msbB, purI genes and has advanced to clinical stages, while there were still potential biosafety hazards in using live bacteria. 63 In this study, we leveraged the membrane debris from the attenuated Salmonella strain, which automatically assembled into DMVs, thus successfully reducing the live bacterial virulence and increasing the systemic safety. Besides, the entire process of DMV production did not require any sophisticated synthesis technologies and could be scaled up cost-effectively.…”

Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

“… 156 , 157 Emerging studies have indicated that hypoxia in the tumor microenvironment promotes tumor progression, and thus, hypoxia could be regarded as a prognostic factor for metastasis. 32 , 158 , 159 There are significantly fewer N1-like TANs in groups with high hypoxia than in the groups without hypoxia, suggesting that hypoxia might contribute to evasion of immune surveillance and promotion of tumor metastasis by reducing antitumor immune cells. 157 However, both studies described above only considered the total TAN number without taking functional differences between subtypes into account, which may be due to the difficulty in recognizing specific biomarkers.…”

“…29,30 Therefore, versatile nanoplatforms, including biomimetic nanoparticles, inorganic nanomaterials, and organic nanomaterials, have been used to effectively modulate the immune microenvironment. [31][32][33] Importantly, some immunomodulatorybased nanoplatforms have achieved satisfactory therapeutic effects in the preclinical study of osteosarcoma. 34 For these reasons, managing the osteosarcoma immune microenvironment and using nanomedicines in enhanced immunotherapy are gaining widespread attention as personalized treatment regimens.…”

Nanozyme‐Coated Bacteria Hitchhike on CD11b+ Immune Cells to Boost Tumor Radioimmunotherapy

“…Bacterial-based delivery strategies have recently emerged as a pivotal research direction in the field of drug delivery and DOI: 10.1002/adma.202309332 have garnered widespread attention. [1][2][3][4][5] Compared to traditional drug delivery carriers, bacteria possess the natural ability to target tumors or other pathological tissues. [2,6] In recent years, various types of engineered bacteria have been developed through genetic engineering and synthetic biology to perform specific tasks, such as producing therapeutic proteins, releasing drugs, or responding to environmental stimuli.…”