Advances of Direct Peripheral Nerve Repair Techniques: Do We Already Have Enough Scientific Evidence?

Silva, Jefferson Braga; Becker, Alice Scalzilli; Leal, Bruna Leiria Meréje; Busnello, Catarina

doi:10.1007/s43465-022-00791-5

Cited by 5 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If there is tension, as a practical rule beyond the holding strength of a 9-0 suture, a nerve graft is preferable despite the resultant double suture lines. There is limited evidence to support the use of one suturing technique (Figure 1) (epineural/perineural/epiperineural/glue) over another (Silva et al., 2023).…”

Section: Nerve Injury Without Gapmentioning

confidence: 99%

Current perspectives on peripheral nerve repair and management of the nerve gap

McMorrow,

Czarnecki,

Reid

et al. 2024

J Hand Surg Eur Vol

View full text Add to dashboard Cite

From the first surgical repair of a nerve in the 6th century, progress in the field of peripheral nerve surgery has marched on; at first slowly but today at great pace. Whether performing primary neurorrhaphy or managing multiple large nerve defects, the modern nerve surgeon has an extensive range of tools, techniques and choices available to them. Continuous innovation in surgical equipment and technique has enabled the maturation of autografting as a gold standard for reconstruction and welcomed the era of nerve transfer techniques all while bioengineers have continued to add to our armamentarium with implantable devices, such as conduits and acellular allografts. We provide the reader a concise and up-to-date summary of the techniques available to them, and the evidence base for their use when managing nerve transection including current use and applicability of nerve transfer procedures.

show abstract

Section: Nerve Injury Without Gapmentioning

confidence: 99%

Current perspectives on peripheral nerve repair and management of the nerve gap

McMorrow,

Czarnecki,

Reid

et al. 2024

J Hand Surg Eur Vol

View full text Add to dashboard Cite

show abstract

“…The aim of this study was to evaluate the effectiveness of the use of fibrin glue (Tisseel ® ) in securing a nerve graft without the use of sutures and compare the outcomes to those of traditional microsurgical repair. This method could reduce the suture line inflammation, and therefore scarring, improving axonal regeneration and accelerating the time of functional recovery [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Nerve Regeneration after a Nerve Graft in a Rat Model: The Effectiveness of Fibrin Glue

Zabbia,

Toia,

Coppola

et al. 2024

JPM

View full text Add to dashboard Cite

Background: Simulating the post-traumatic continuity defect of small human peripheral nerves, we compared the effectiveness of fibrin glue with neurorrhaphy for nerve gap restoration. Methods: In twenty-four male Wistar rats, a fifteen mm defect in one sciatic nerve only was made and immediately repaired with an inverted polarity autograft. According to the used technique, rats were divided into Group A (Control), using traditional neurorrhaphy, and Group B (Study), using fibrine glue sealing; in total, 50% of rats were sacrificed at 16 weeks and 50% at 21 weeks. Before sacrifice, an assessment of motor function was done through Walking Track Analysis and an electroneurophysiological evaluation. After sacrifice, selected muscle mass indexes and the histology of the regenerated nerves were assessed. All data were evaluated by Student’s t test for unpaired data. Results: No significant differences were found between the two groups, with only the exception of a relative improvement in the tibialis anterior muscle’s number of motor units in the study group. Conclusion: Despite the fact that the use of fibrin glue as a nerve sealant is not superior in terms of functional recovery, its effectiveness is comparable to that of microsurgical repair. Hence, the faster and technically easier glueing technique could deserve broader clinical application.

show abstract