Advances of immune checkpoints in colorectal cancer treatment

Jiao, Qinlian; Ren, Yidan; Gabrie, Abakundana Nsenga Ariston; Wang, Qin; Wang, Yuli; Li, Du; Liu, Xiaoyan; Wang, Chuanxin; Wang, Yunshan

doi:10.1016/j.biopha.2019.109745

Cited by 29 publications

(22 citation statements)

References 69 publications

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“…Inflammatory pain is a complex symptom involving multiple modulators consisting of neurotransmitters, receptors, ion channels and signaling pathways (Jiao et al, 2020). Previous studies documented that NF‐ κ B, as a ubiquitously expressed transcription factor, could effectively initiate the inflammatory response to mediate cell proliferation, apoptosis and metastasis (Sethi, Sung, & Aggarwal, 2008).…”

Section: Discussionmentioning

confidence: 99%

The related mechanism of complete Freund's adjuvant‐induced chronic inflammation pain based on metabolomics analysis

Zhang

Jie

et al. 2021

Biomedical Chromatography

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Chronic inflammation pain is a debilitating disease, and its mechanism still remains poorly understood. This study attempted to illuminate the metabolic mechanism of chronic inflammation pain induced by complete Freund’s adjuvant (CFA) injection, especially at spinal level. The chronic inflammation pain model was established by CFA administration. Behavioral testing including mechanical allodynia and thermal hyperalgesia was performed. Meanwhile, a liquid chromatography–mass spectrometry‐based metabolomics approach was applied to analyze potential metabolic biomarkers. The orthogonal partial least squares discrimination analysis mode was employed for determining metabolic changes, and a western blot was performed to detect the protein expression change. The results showed that 27 metabolites showed obviously abnormal expression and seven metabolic pathways were significantly enriched, comprising aminoacyl‐tRNA biosynthesis, arginine and proline metabolism, histidine metabolism, purine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, glutathione metabolism, and phenylalanine metabolism. Meanwhile, the results showed that the expression of arginase I and nitric oxide levels were elevated in the CFA group compared with the control group, while the argininosuccinate synthetase and argininosuccinatelyase proteins were not significantly different between the groups. These findings demonstrate that metabolic changes of the spinal cord may be implicated in neurotransmitter release and pain conductivity following CFA administration.

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Section: Discussionmentioning

confidence: 99%

The related mechanism of complete Freund's adjuvant‐induced chronic inflammation pain based on metabolomics analysis

Zhang

Jie

et al. 2021

Biomedical Chromatography

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“…early detection methods for CRC involve colonoscopic, fecal, and blood sample examinations. According to the tumor size, location, and degree, as well as genetic changes and the patient's health status, CRC treatment can include surgery, chemotherapy, radiotherapy, molecular-targeted therapy, and immunotherapy (2)(3)(4)(5).…”

Section: Identification Of Gene Biomarkers and Immune Cell Infiltration Characteristics In Rectal Cancermentioning

confidence: 99%

Identification of gene biomarkers and immune cell infiltration characteristics in rectal cancer

Wen

Han

2021

J Gastrointest Oncol

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“…PD-1/PD-L1 antibody blocks this signal pathway and enhances the sustained killing effect of cytotoxic T lymphocytes on tumor cells without transforming their essence, which can even deplete the cells. The effector cells restore the immune killing function, nally boosting the tumor-killing effect (16). Immunotherapy has the advantages of good tolerance and mild side effects, as an eligible option for patients with refractory cancer after multiline treatment failure.…”

Section: Characteristics Of Samplesmentioning

confidence: 99%

A qualitative investigation of influencing factors for anxiety and depression in patients with advanced cancer after multiline treatment failure

Yang

Xie

Sun

et al. 2020

Preprint

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Background: To investigate the anxiety and depression of patients with advanced cancer who received immunotherapy using programmed death-1 or programmed death-ligand 1 after multiline treatment failure, to explore the influencing factors, and to provide reference for clinical medical staff and psychological support for patients.Methods: The Hospital Anxiety and Depression Scale was used to calculate the anxiety and depression scores before and after 1, 2 and 3 courses of treatment, respectively. The patients with anxiety and depression were counted. Purposive sampling was used to conduct face-to-face semi-structured interviews with 21 patients to find out the reasons. The obtained data were analyzed and collated using the Colaizzi's phenomenological method.Results: Before and after 1, 2 and 3 courses of treatment, 18.26%, 23.0%, 50% and 54% of patients suffered from anxiety and depression, respectively. Four related factors, i.e. low expectations for immunotherapy, lack of timely information after treatment, lack of awareness of treatment and drugs, and lack of family and social support, were extracted with the sampling survey. The proportion of patients with anxiety and depression during immunotherapy kept increasing.Conclusion: The anxiety and depression of patients with advanced cancer who receive immunotherapy after multiline treatment failure are aggravated along with treatment. Patients need to be given humane care and emotional support from their families, society and medical staff. Nursing staff should adopt personalized measures to meet the psychological needs of patients, and a targeted and complete nursing system should be established to extend the life span and to improve the quality of life.Trial registration: ChiCTR, ChiCTR1800015942. Registered 1 May 2018, http://www.chictr.org.cn/showproj.aspx?proj=26476

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Advances of immune checkpoints in colorectal cancer treatment

Cited by 29 publications

References 69 publications

The related mechanism of complete Freund's adjuvant‐induced chronic inflammation pain based on metabolomics analysis

The related mechanism of complete Freund's adjuvant‐induced chronic inflammation pain based on metabolomics analysis

Identification of gene biomarkers and immune cell infiltration characteristics in rectal cancer

A qualitative investigation of influencing factors for anxiety and depression in patients with advanced cancer after multiline treatment failure

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