Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery

Abstract

Review Advances of the Target-Based and Phenotypic Screenings and Strategies in Drug Discovery Shoubao Wang 1,*, Zihan Wang1, Lianhua Fang1, Yang Lv2, and Guanhua Du1,* 1 Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. 2 Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. * Correspondence: shoubaowang@imm.ac.cn (Shoubao Wang); dugh@imm.ac.cn (Guanhua Du). Received: 8 November 2022 Accepted: 15 November 2022 Published: 21 December 2022 Abstract: Drug discovery and development is a complex and expensive process. There are two approaches, phenotypic and target-based approaches, each holding different advantages for screening novel drug candidates when pursuing successful marketing authorization. However, the attrition rates of drug candidates continue to increase. In this review, we discuss recent successes and ongoing advances in phenotypic screening and target-based screening for drug discovery. We also explore how strategic and technological innovations may fuel new approaches in drug discovery. There are two approaches in drug discovery.

Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research

“…New drug candidates are identified within the early and full phases of drug discovery research via complex and challenging multidisciplinary and multistep scientific endeavors (Figure ). The process begins by steadfastly increasing our understanding of disease biology via molecular and empirical approaches to uncover new ways of targeting drivers of disease. − Suitable assays and screening paradigms (e.g., virtual, fragment-based, and high-throughput screens) are developed to identify hits for disease targets. These hits are further evolved into leads through a progression of comprehensive investigations.…”

Virtual Screening and ADMET Prediction to Uncover the Potency of Flavonoids from Genus Erythrina as Antibacterial Agent through Inhibition of Bacterial ATPase DNA Gyrase B

“…Target-based approaches emerged in line with the development of chemistry and pharmacology in the early 20th century. In recent decades, drug discovery with target-based approaches has become a major paradigm in the early stages of drug discovery; this approach has increased the screening capacity of drug compounds and improved the rationalization of drug discovery [5].…”

Current Progress in Drug Target Identification and Drug Delivery

“…Wang and Du et al from Beijing Key Laboratory of Drug Targets Identification and Drug Screening denote two approaches in drug discovery, i.e., phenotype and target-based approaches, each holding different advantages for screening novel drug candidates when pursuing successful marketing authorization [1]. They also outline the progress of modern drug discovery.…”