Advances on Automatic Speech Analysis for Early Detection of Alzheimer Disease: A Non-linear Multi-task Approach

Ipiña, Karmele López de; Martinez-de-Lizarduy, U.; Calvo, Pilar M.; Mekyska, Jiří; Beitia, B.; Barroso, Nora; Estanga, Ainara; Tainta, Mikel; Ecay-Torres, Mirian

doi:10.2174/1567205014666171120143800

Cited by 61 publications

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“…Different sample sizes and the use of nonparametric tests are common in studies with people with dementia. Voice studies like López-De-Ipiña et al [50], Hoffmann et al [23], or Beltrami et al [51] have followed this path.…”

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confidence: 98%

Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia

Meilán

Sánchez

Martínez-Nicolás

et al. 2020

Behavioural Neurology

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This study explores several speech parameters related to mild cognitive impairment, as well as those that might be flagging the presence of an underlying neurodegenerative process. Speech is an excellent biomarker because it is not invasive and, what is more, its analysis is rapid and economical. Our aim has been to ascertain whether the typical speech patterns of people with Alzheimer’s disease are also present during the disorder’s preclinical stages. To do so, we shall be using a task that involves reading out aloud. This is followed by an analysis of the recordings, looking for the possible parameters differentiating between those older people with MCI and a high probability of developing dementia and those with MCI that will not do so. We found that the disease’s most differentiating parameters prior to its onset involve changes in speech duration and an alteration in rhythm rate and intensity. These parameters seem to be related to the first difficulties in lexical access among older people with AD.

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confidence: 98%

Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia

Meilán

Sánchez

Martínez-Nicolás

et al. 2020

Behavioural Neurology

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“…Most significantly, thanks to the vigorous development of Graphics Processing Units (GPUs) for parallel computing, a current mainstream process is to adopt deep learning methods to replace traditional classifiers. Examples include biomedical imaging and wave recognition [18,19]; speech recognition [20,21]; biomedical signal detection [18,19,22]; cancer identification [19,22,23]; potential drug discovery [24,25]; and adverse drug effects [26]. Images of the drug are pre-processed to obtain the correct viewing angle and drug separation, and the characteristics of the pills are established manually [27].…”

Section: Introductionmentioning

confidence: 99%

A drug identification model developed using deep learning technologies: experience of a medical center in Taiwan

Ting

Chung

Chen

et al. 2020

BMC Health Serv Res

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Background: Issuing of correct prescriptions is a foundation of patient safety. Medication errors represent one of the most important problems in health care, with 'look-alike and sound-alike' (LASA) being the lead error. Existing solutions to prevent LASA still have their limitations. Deep learning techniques have revolutionized identification classifiers in many fields. In search of better image-based solutions for blister package identification problem, this study using a baseline deep learning drug identification (DLDI) aims to understand how identification confusion of look-alike images by human occurs through the cognitive counterpart of deep learning solutions and thereof to suggest further solutions to approach them. Methods: We collected images of 250 types of blister-packaged drug from the Out-Patient Department (OPD) of a medical center for identification. The deep learning framework of You Only Look Once (YOLO) was adopted for implementation of the proposed deep learning. The commonly-used F1 score, defined by precision and recall for large numbers of identification tests, was used as the performance criterion. This study trained and compared the proposed models based on images of either the front-side or back-side of blister-packaged drugs. Results: Our results showed that the total training time for the front-side model and back-side model was 5 h 34 min and 7 h 42 min, respectively. The F1 score of the back-side model (95.99%) was better than that of the frontside model (93.72%). Conclusions:In conclusion, this study constructed a deep learning-based model for blister-packaged drug identification, with an accuracy greater than 90%. This model outperformed identification using conventional computer vision solutions, and could assist pharmacists in identifying drugs while preventing medication errors caused by look-alike blister packages. By integration into existing prescription systems in hospitals, the results of this study indicated that using this model, drugs dispensed could be verified in order to achieve automated prescription and dispensing.

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“…Most significantly, thanks to the vigorous development of Graphics Processing Units (GPUs) for parallel computing, a current mainstream process is to adopt deep learning methods to replace traditional classifiers. Examples include biomedical imaging and wave recognition [18,19]; speech recognition [20,21]; biomedical signal detection [18,19,22]; cancer identification [19,22,23]; potential drug discovery [24,25]; and adverse drug effects [26]. Images of the drug are preprocessed to obtain the correct viewing angle and drug separation, and the characteristics of the pills are established manually [27].…”

Section: Introductionmentioning

confidence: 99%

A Drug Identification Model developed using Deep Learning Technologies: Experience of a Medical Center in Taiwan

Ting

Chung

Chen

et al. 2020

Preprint

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Background: Issuing of correct prescriptions is a foundation of patient safety. Medication errors represent one of the most important problems in health care, with ‘look-alike and sound-alike’ (LASA) being the lead error. Existing solutions to prevent LASA still have their limitations. Deep learning techniques have revolutionized identification classifiers in many fields. In search of better image-based solutions for blister package identification problem, this study using a baseline deep learning drug identification (DLDI) aims to understand how identification confusion of look-alike images by human occurs through the cognitive counterpart of deep learning solutions and thereof to suggest further solutions to approach them.Methods: We collected images of 250 types of blister-packaged drug from the Out-Patient Department (OPD) of a medical center for identification. The deep learning framework of You Only Look Once (YOLO) was adopted for implementation of the proposed deep learning. The commonly-used F1 score, defined by precision and recall for large numbers of identification tests, was used as the performance criterion. This study trained and compared the proposed models based on images of either the front-side or back-side of blister-packaged drugs. Results: Our results showed that the total training time for the front-side model and back-side model was 5 hours 34 minutes and 7 hours 42 minutes, respectively. The F1 score of the back-side model (95.99%) was better than that of the front-side model (93.72%). Conclusions: In conclusion, this study constructed a deep learning-based model for blister-packaged drug identification, with an accuracy greater than 90%. This model outperformed identification using conventional computer vision solutions, and could assist pharmacists in identifying drugs while preventing medication errors caused by look-alike blister packages. By integration into existing prescription systems in hospitals, the results of this study indicated that using this model, drugs dispensed could be verified in order to achieve automated prescription and dispensing.

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Advances on Automatic Speech Analysis for Early Detection of Alzheimer Disease: A Non-linear Multi-task Approach

Abstract: Finally, the most relevant features are selected by means of the non-parametric Mann- Whitney U-test.

Cited by 61 publications

References 0 publications

Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia

Changes in the Rhythm of Speech Difference between People with Nondegenerative Mild Cognitive Impairment and with Preclinical Dementia

A drug identification model developed using deep learning technologies: experience of a medical center in Taiwan

A Drug Identification Model developed using Deep Learning Technologies: Experience of a Medical Center in Taiwan

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