Using a quasi‐experimental, cross‐sectional design, we examined coping differences among American adolescents who reported a history of nonsuicidal self‐injury (NSSI; n = 90, 25.7%) and those without a history of NSSI (n = 260, 74.3%). Findings from a profile analysis indicated that a measurable difference in coping profiles may exist between those with a history of NSSI and those without a history of NSSI. Specifically, adolescents who have a history of NSSI appear to rely upon, at higher rates, maladaptive methods of coping, including acting out and rumination, in comparison to adolescents who have never engaged in NSSI, who appear to rely upon adaptive methods of coping, including distraction and self‐care, at higher rates. No meaningful difference was apparent between groups on seeking social support as a method of coping. These findings confirm the importance of assessing and enhancing effective coping strategies among adolescent clients who self‐injure and potentially utilizing coping skill enhancement strategies as a form of NSSI prevention.