With increasing concerns of labor issue risks within supply chains, both academia and practitioners are paying increasingly great attention to how to design and implement effective management approaches to enhance labor sustainability in supply chains. Furthermore, digitalization facilitates and brings both opportunities and challenges to this area. Using the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), we conducted a systematic literature review based on 50 selected papers from the Web of Science database. Starting from the supply chain level, this study identifies digital technology (DT)-enabled labor sustainability management practices, barriers to the adoption of DT in labor management practices, and the performance outcomes of such practices. In addition, we put forward solutions to eliminate those identified barriers to facilitate DT adoption in firms’ labor sustainability management. Last, future directions and research opportunities for both supply chain management and labor sustainability are summarized.