Advantages of methohexital over amobarbital in determining hemispheric language and memory lateralization in the Wada test – A retrospective study

Conradi, Nadine; Rosenberg, Friederike; Biermann, Louise; Haag, Anja; Hermsen, A.; Gorny, Iris; Podewils, Viola von; Gurschi, Mariana; Keil, Fee; Hattingen, Elke; Menzler, Katja; Bauer, Sebastian; Schubert‐Bast, Susanne; Knake, Susanne; Rosenow, Felix; Strzelczyk, Adam

doi:10.1016/j.yebeh.2020.107551

Cited by 3 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As described elsewhere 48 , all patients underwent internal carotid artery catheterization via the right femoral artery. After a contrast medium was injected to determine the location of the catheter and to control for crossflow, a barbiturate injection (using amobarbital in 75.0% and methohexital in 25.0% of patients) followed, leading to an inactivation of brain structures supplied by the injected vessel.…”

Section: Methodsmentioning

confidence: 99%

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Conradi

Rosenberg

Knake

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R2 = 0.233, p = .032) and verbal memory function (∆R2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.

show abstract

Section: Methodsmentioning

confidence: 99%

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Conradi

Rosenberg

Knake

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

Balloon Test Occlusion, Wada Test and Inferior Petrosal Sinus Sampling

Balushi

Knopman

2022

Introduction to Vascular Neurosurgery

View full text Add to dashboard Cite

Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy

Massot‐Tarrús

Mirsattari

2022

Front. Neurol.

View full text Add to dashboard Cite

Surgical treatment of pharmacoresistant temporal lobe epilepsy (TLE) carries risks for language function that can significantly affect the quality of life. Predicting the risks of decline in language functions before surgery is, consequently, just as important as predicting the chances of becoming seizure-free. The intracarotid amobarbital test, generally known as the Wada test (WT), has been traditionally used to determine language lateralization and to estimate their potential decline after surgery. However, the test is invasive and it does not localize the language functions. Therefore, other noninvasive methods have been proposed, of which functional magnetic resonance (fMRI) has the greatest potential. Functional MRI allows localization of language areas. It has good concordance with the WT for language lateralization, and it is of predictive value for postsurgical naming outcomes. Consequently, fMRI has progressively replaced WT for presurgical language evaluation. The objective of this manuscript is to review the most relevant aspects of language functions in TLE and the current role of fMRI and WT in the presurgical evaluation of language. First, we will provide context by revising the language network distribution and the effects of TLE on them. Then, we will assess the functional outcomes following various forms of TLE surgery and measures to reduce postoperative language decline. Finally, we will discuss the current indications for WT and fMRI and the potential usefulness of the resting-state fMRI technique.

show abstract

Advantages of methohexital over amobarbital in determining hemispheric language and memory lateralization in the Wada test – A retrospective study

Cited by 3 publications

References 24 publications

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Balloon Test Occlusion, Wada Test and Inferior Petrosal Sinus Sampling

Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy

Contact Info

Product

Resources

About