Adverse childhood experiences in patients with psoriasis

Akamine, A; Rusch, Gabriela de Souza; Nisihara, Renato; Skare, Thelma Larocca

doi:10.47626/2237-6089-2021-0251

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Researchers had previously found that ACEs were associated with an increased chance of development of obesity in adulthood 8 as well as development of other chronic health conditions such as high blood pressure, 9 diabetes, 5,10 atopic dermatitis, 11 and psoriasis. 12 While a direct mechanism of association has not been determined for these conditions, different biological pathways have been proposed to explain this phenomenon. One pathway suggests that ACEs cause a change in epigenetic mechanisms to the immune system, which may ultimately predispose patients exposed to ACEs to illness as well as chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Adverse childhood experiences (ACEs) and associated health outcomes among adults with skin cancer

AV Okeke,

P Williams,

H Tran

et al. 2023

JDC

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Background: Ongoing investigations established the relationship between adverse childhood experiences (ACEs) and chronic diseases, such as high blood pressure, diabetes, atopic dermatitis, and psoriasis. However, the specific association between ACEs and skin cancer remains relatively unexplored in scientific literature. Objective: This study aimed to evaluate the relationship between adverse childhood experiences (ACEs) and measures of health-related quality of life (HRQOL) among individuals with a skin cancer diagnosis. Methods: Data from the 2019 Behavioral Risk Factors and Surveillance Study (BRFSS) were analyzed. The study included 418,268 adults, with 41,773 individuals diagnosed with skin cancer. HRQOL measures, including physical health, mental health, and lifestyle impairment, were assessed using self-reported data. ACEs were identified through participants' responses to 11 specific questions. Multivariable logistic regression analyses adjusted for demographic variables. Results: Skin cancer survivors with a history of ACEs reported significantly poorer physical health (OR 1.39, 95% CI 1.24-1.56) and mental health (OR 2.13, 95% CI 1.81-2.51) compared to those without ACEs. They also experienced higher levels of lifestyle impairment related to health (OR 1.31, 95% CI 1.16-1.48). Commonly reported ACEs included parental separation, exposure to domestic violence, and verbal abuse. Discussion: This study highlights the detrimental impact of childhood maltreatment on HRQOL among skin cancer survivors. Healthcare professionals should be attentive to the unique needs of this population by providing comprehensive support and interventions. Conclusion: Childhood maltreatment has a significant negative impact on HRQOL among skin cancer survivors. The study emphasizes the importance of addressing the psychological and emotional well-being of individuals with a history of ACEs. Healthcare professionals should consider the specific needs of this vulnerable population to provide appropriate care and support. Further research is required to deepen our understanding of the underlying mechanisms and to develop effective interventions to improve the well-being of skin cancer survivors with a history of childhood maltreatment. Furthermore, longitudinal analyses and objective measures are needed to establish causal relationships and mitigate potential biases.

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Section: Discussionmentioning

confidence: 99%

Adverse childhood experiences (ACEs) and associated health outcomes among adults with skin cancer

AV Okeke,

P Williams,

H Tran

et al. 2023

JDC

View full text Add to dashboard Cite

show abstract

“…Adult obesity [67] Adverse childhood event Arterial stiffness Cardiovascular Disease [68] Adverse childhood experiences Female psoriasis patients had more ACEs than controls or male patients. Psoriasis [69] Adverse childhood experiences Evaluated in adulthood and specifically associated with other ACE comorbidities (e.g., depression).…”

Section: Period Of Early Life Biomarkers (Population Subset) Ncd/cd E...mentioning

confidence: 99%

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences

Dietert

Dietert²

2022

Microorganisms

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Adverse childhood experiences (ACEs), which can include child trafficking, are known to program children for disrupted biological cycles, premature aging, microbiome dysbiosis, immune-inflammatory misregulation, and chronic disease multimorbidity. To date, the microbiome has not been a major focus of deprogramming efforts despite its emerging role in every aspect of ACE-related dysbiosis and dysfunction. This article examines: (1) the utility of incorporating microorganism-based, anti-aging approaches to combat ACE-programmed chronic diseases (also known as noncommunicable diseases and conditions, NCDs) and (2) microbiome regulation of core systems biology cycles that affect NCD comorbid risk. In this review, microbiota influence over three key cyclic rhythms (circadian cycles, the sleep cycle, and the lifespan/longevity cycle) as well as tissue inflammation and oxidative stress are discussed as an opportunity to deprogram ACE-driven chronic disorders. Microbiota, particularly those in the gut, have been shown to affect host–microbe interactions regulating the circadian clock, sleep quality, as well as immune function/senescence, and regulation of tissue inflammation. The microimmunosome is one of several systems biology targets of gut microbiota regulation. Furthermore, correcting misregulated inflammation and increased oxidative stress is key to protecting telomere length and lifespan/longevity and extending what has become known as the healthspan. This review article concludes that to reverse the tragedy of ACE-programmed NCDs and premature aging, managing the human holobiont microbiome should become a routine part of healthcare and preventative medicine across the life course.

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Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

Dietert¹,

Dietert²

2021

Preprint

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Adverse childhood experiences are known to program children for disrupted biological cycles, premature aging, microbiome dysbiosis, immune-inflammatory misregulation, and chronic disease multimorbidity. To date, the microbiome has not been a major focus of deprogramming efforts despite its emerging role in every aspect of ACE-related dysbiosis and dysfunction. This article examines: 1) the utility of incorporating microorganism-based, anti-aging approaches to combat ACE-programmed chronic diseases (also known as noncommunicable diseases and conditions, NCDs) and 2) microbiome regulation of core systems biology cycles that affect NCD comorbid risk. In this review microbiota influence over three key cyclic rhythms (circadian cycles, the sleep cycle, and the lifespan/longevity cycle) as well as tissue inflammation and oxidative stress are discussed as an opportunity to deprogram ACE-driven chronic disorders. Microbiota, particularly those in the gut, have been shown to affect host-microbe interactions regulating the circadian clock, sleep quality, as well as immune function/senescence and regulation of tissue inflammation. The microimmunosome is one of several systems biology targets of gut microbiota regulation. Furthermore, correcting misregulated inflammation and increased oxidative stress is key to protecting telomere length and lifespan/longevity and extending what has become known as the healthspan. This review article concludes that to reverse the tragedy of ACE-programmed NCDs and premature aging, managing the human holobiont microbiome should become a routine part of healthcare and preventative medicine across the life course.

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Adverse childhood experiences in patients with psoriasis

Cited by 3 publications

References 19 publications

Adverse childhood experiences (ACEs) and associated health outcomes among adults with skin cancer

Adverse childhood experiences (ACEs) and associated health outcomes among adults with skin cancer

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

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