Adverse cutaneous reactions to skin care products on the face vary with age, but not with sex

Huang, Lining; Zhong, Yiping; Liú, Dan; Wang, Xiaohua; Gong, Can‐yi; Wen, Shusheng; Elias, Peter M.; Yang, Bin; Man, Mao‐Qiang

doi:10.1111/cod.13102

Cited by 17 publications

(13 citation statements)

References 33 publications

(59 reference statements)

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“…Correspondingly, we show here that skin care products were the number one factor associated with sensitive skin on the face of normal young Chinese. This finding parallels with recent observations that skin care products increasingly cause adverse cutaneous reactions . That more females than males proclaimed skin care products as trigger factor is likely linked to a higher prevalence of adverse cutaneous reactions to skin care products in females (Table ), possibly due to that more females than males used skin care products (24% vs 10%).…”

Section: Discussionmentioning

confidence: 99%

Gender‐related characterization of sensitive skin in normal young Chinese

Wang

Zheng

et al. 2019

J of Cosmetic Dermatology

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Background: While clinical signs, symptoms, as well as etiology of sensitive skin in general populations have been extensively studied over the last decades, characteristics of sensitive skin in normal subjects, particularly gender-related characteristics, still remain unknown.Objective: In the present study, we characterize facial sensitive skin in normal young Chinese. Subjects and Methods:A questionnaire was given to each participant aged 10-30 years. Clinical signs, symptoms, and associated trigger factors of facial sensitive skin were compared in normal young Chinese males versus females.Results: After excluding subjects with pre-existing skin disorders, 475 females and 429 males out of 954 responders were included in the analyzes. Prevalence of selfreported facial sensitive skin was significantly higher in females than in males. Yet, while more females experienced various symptoms, symptoms were more severe in males than in females. However, both the prevalence and severity of clinical signs were similar in females and males. Skin care products appeared to be the major contributors to facial sensitive skin in both genders. Moreover, it appeared that females were more sensitive to environmental factors such as low humidity and sun-exposure while males were more sensitive to emotional factors. Taken together, these results demonstrate that characteristics of sensitive skin are associated with gender, while the underlying mechanisms remain to be explored. Conclusions:There are gender differences in prevalence, symptoms, and trigger factors of facial sensitive skin in normal young Chinese. K E Y W O R D S gender, prevalence, sensitive skin, skin care products S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Wang X, Su Y, Zheng B, et al. Gender-related characterization of sensitive skin in normal young Chinese.

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Section: Discussionmentioning

confidence: 99%

Gender‐related characterization of sensitive skin in normal young Chinese

Wang

Zheng

et al. 2019

J of Cosmetic Dermatology

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“…A wide range of ingredients can improve epidermal function. However, it is worth noting that a substantial portion of emollients on the market are harmful to epidermal function, although some ingredients in these products may benefit epidermal function [142][143][144][145]. The harmful emollients often contain some ingredient, such as eicosadienoic acid-enriched oils, stearic acid, ceteareth 20, PEG-40 castor oil and PEG-100 stearate, which all can induce cutaneous inflammation and/or disrupt epidermal permeability barrier [145][146][147][148].…”

Section: Natural Ingredientsmentioning

confidence: 99%

Aging-associated alterations in epidermal function and their clinical significance

Wang¹,

Man

Li³

et al. 2020

Aging

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105

104

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INTRODUCTION With advances in medical biology and healthcare technology over recent decades, human lifespans are increasing worldwide, with lifespan expectations of up to 100 years in developed countries by 2025 [1], resulting in a proportionate increase in the aged population. As early as 50 years of age, the frequency of aging-associated cutaneous disorders increases, in parallel with epidermal dysfunction, including compromised permeability homeostasis and reductions in levels of stratum corneum hydration, as well as elevations in skin surface pH, the most prominent features associated with chronic aging. Studies have shown that epidermal dysfunction, in turn, predisposes to the development of a variety of cutaneous abnormalities, including atopic dermatitis, contact dermatitis, pruritus and xerosis, and possibly agingassociated systemic disorders [2-5]. In this review, we discuss aging-associated alterations in epidermal function and their link to cutaneous disorders. Aging-associated alterations in epidermal function Compromised epidermal permeability barrier homeostasis Aging-associated changes in baseline transepidermal water loss (TEWL) rates, an indicator of epidermal permeability barrier, vary greatly with gender, body sites and pigment types. While some studies have shown that baseline TEWL rates on several body sites are lower in the aged than in young skin [6-12], other

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“…Thus, skin care product makers have been striving to develop products that can potently improve epidermal permeability barrier function. Because of the high incidence of adverse cutaneous reactions to skin care products, identification of safe and effective ingredients is becoming emergent [92, 93]. Our group has demonstrated that twice-daily applications of 2% hesperidin to young mouse skin for 6 days accelerated permeability barrier recovery in a model of acute barrier disruption although basal transepidermal water loss rates, stratum corneum hydration, and skin surface pH remained unchanged [31].…”

Section: Benefits Of Hesperidin For Cutaneous Functionsmentioning

confidence: 99%

Benefits of Hesperidin for Cutaneous Functions

Man

Yang

Elias

2019

Evidence-Based Complementary and Alternative Medicine

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106

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Hesperidin is a bioflavonoid, with high concentration in citrus fruits. In addition to its well-known benefits for cardiovascular function, type II diabetes, and anti-inflammation, recent studies have demonstrated multiple benefits of hesperidin for cutaneous functions, including wound healing, UV protection, anti-inflammation, antimicrobial, antiskin cancer, and skin lightening. In addition, hesperidin enhances epidermal permeability barrier homeostasis in both normal young and aged skin. The mechanisms by which hesperidin benefits cutaneous functions are attributable to its antioxidant properties, inhibition of MAPK-dependent signaling pathways, and stimulation of epidermal proliferation, differentiation, and lipid production. Because of its low cost, wide availability, and superior safety, hesperidin could prove useful for the management of a variety of cutaneous conditions.

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Adverse cutaneous reactions to skin care products on the face vary with age, but not with sex

Abstract: Our results indicate that pruritus, xerosis and erythema are common adverse cutaneous reactions to facial skin care products. These reactions vary with age, but not with sex. Vigorous safety testing should precede the marketing of skin care products.

Cited by 17 publications

References 33 publications

Gender‐related characterization of sensitive skin in normal young Chinese

Gender‐related characterization of sensitive skin in normal young Chinese

Aging-associated alterations in epidermal function and their clinical significance

Benefits of Hesperidin for Cutaneous Functions

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