Adverse drug interactions in dentistry

Hersh, Elliot V.; Moore, Paul A.

doi:10.1111/j.1600-0757.2008.00224.x

Cited by 43 publications

(39 citation statements)

References 220 publications

(291 reference statements)

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“…Therefore, this technique may be helpful in patients who possess multi-drug-resistant bacteria at periodontal sites. 30 Moreover, patients with leukemia who do not show a response to conventional treatments 31 may benefit from PDT, which is a technique that can affect oral micro-organisms without inducing oral trauma.…”

Section: Discussionmentioning

confidence: 99%

Histomorphometric and Microbiological Assessment of Photodynamic Therapy as an Adjuvant Treatment for Periodontitis: A Short-Term Evaluation of Inflammatory Periodontal Conditions and Bacterial Reduction in a Rat Model

Prates

Yamada

Suzuki

et al. 2011

Photomedicine and Laser Surgery

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Section: Discussionmentioning

confidence: 99%

Histomorphometric and Microbiological Assessment of Photodynamic Therapy as an Adjuvant Treatment for Periodontitis: A Short-Term Evaluation of Inflammatory Periodontal Conditions and Bacterial Reduction in a Rat Model

Prates

Yamada

Suzuki

et al. 2011

Photomedicine and Laser Surgery

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“…Many publications have mentioned the importance of limiting the epinephrine doses in dentistry due to adverse effects (24,10). In the experimental group of Vy et al (11), collagen sponges saturated with 10 drops of 2.25% racemic epinephrine were used as haemostatics.…”

Section: Discussionmentioning

confidence: 99%

Haemostatic agents in apical surgery. A systematic review

Clé-Ovejero¹,

Valmaseda‐Castellón²

2016

Med Oral

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BackgroundBlood presence in apical surgery can prevent the correct vision of the surgical field, change the physical properties of filling materials and reduce their sealing ability. ObjetiveTo describe which are the most effective and safest haemostatic agents to control bleeding in patients undergoing apical surgery.Material and MethodsTWe carried out a systematic review, using Medline and Cochrane Library databases, of human clinical studies published in the last 10 years.ResultsThe agents that proved more effective in bleeding control were calcium sulphate (100%) and collagen plus epinephrine (92.9%) followed by ferric sulphate (60%), gauze packing (30%) and collagen (16.7%). When using aluminium chloride (Expasyl®), over 90% of the apical lesions improved, but this agent seemed to increase swelling. Epinephrine with collagen did not significantly raise either blood pressure or heart rate.ConclusionsDespite the use of several haemostatic materials in apical surgery, there is little evidence on their effectiveness and safety. The most effective haemostatic agents were calcium sulphate and epinephrine plus collagen. Epinephrine plus collagen did not seem to significantly raise blood pressure or heart rate during surgery. Aluminium chloride did not increase postoperative pain but could slightly increase postoperative swelling. Randomized clinical trials are needed to assess the haemostatic effectiveness and adverse effects of haemostatic materials in apical surgery. Key words:Haemostasis, apical surgery.

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“…20 DPSGC is highly protein bound, especially to albumin (at least 99%), which at least could theoretically increase blood levels and subsequent toxicity of other highly protein bound drugs such as sulfonylurea hypoglycemic drugs, warfarin, and phenytoin. 20,24 Liver microsomal enzymes, including CYP2C9, 3A4, and 2C8, are responsible for metabolism of DPSGC. CYP2C9 forms the major metabolite, 4…”

Section: Diclofenac Potassium Soft Gelatin Capsulesmentioning

confidence: 99%

“…DPSGC may also increase the toxicity of lithium and high-dose methotrexate by competing with the renal excretion of both. 24 DPSGC has not been well studied in pediatric, pregnant, or geriatric patients or patients who are in labor and delivery or nursing. NSAIDs close the ductus arteriosus by inhibiting prostaglandin synthesis.…”

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confidence: 99%

Three Newly Approved Analgesics: An Update

Saraghi

Hersh

2013

Anesthesia Progress

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Since 2008, three new analgesic entities, tapentadol immediate release (Nucynta) diclofenac potassium soft gelatin capsules (Zipsor), and bupivacaine liposome injectable suspension (EXPAREL) were granted US Food and Drug Administration (FDA) approval to treat acute pain. Tapentadol immediate-release is a both a muopioid agonist and a norepinephrine reuptake inhibitor, and is indicated for the treatment of moderate to severe pain. Diclofenac potassium soft gelatin capsules are a novel formulation of diclofenac potassium, which is a nonsteroidal antiinflammatory drug (NSAID), and its putative mechanism of action is through inhibition of cyclooxygenase enzymes. This novel formulation of diclofenac allows for improved absorption at lower doses. Liposomal bupivacaine is a new formulation of bupivacaine intended for single-dose infiltration at the surgical site for postoperative analgesia. Bupivacaine is slowly released from this liposomal vehicle and can provide prolonged analgesia at the surgical site. By utilizing NSAIDs and local anesthetics to decrease the transmission of afferent pain signals, less opioid analgesics are needed to achieve analgesia. Since drug-related adverse events are frequently dose related, lower doses from different drug classes may be employed to reduce the incidence of adverse effects, while producing synergistic analgesia as part of a multimodal analgesic approach to acute pain.

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Adverse drug interactions in dentistry

Cited by 43 publications

References 220 publications

Histomorphometric and Microbiological Assessment of Photodynamic Therapy as an Adjuvant Treatment for Periodontitis: A Short-Term Evaluation of Inflammatory Periodontal Conditions and Bacterial Reduction in a Rat Model

Histomorphometric and Microbiological Assessment of Photodynamic Therapy as an Adjuvant Treatment for Periodontitis: A Short-Term Evaluation of Inflammatory Periodontal Conditions and Bacterial Reduction in a Rat Model

Haemostatic agents in apical surgery. A systematic review

Three Newly Approved Analgesics: An Update

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