Adverse drug reactions to antiretroviral therapy (ART): an experience of spontaneous reporting and intensive monitoring from ART centre in India

Modayil, Retty Rajan; Harugeri, Anand; Parthasarathi, G; Ramesh, Madhan; Prasad, Rajendra; Naik, V.R.; Giriyapura, Vamadeva

doi:10.1002/pds.1907

Cited by 47 publications

(49 citation statements)

References 34 publications

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“…Treatment of clinically evaluated ADR consisted of counseling (78%). Modayil et al, Khalili et al, found similar results [19,23]. Our study summarized the dominant complaints of patients and observations of physicians following antiretroviral therapy.…”

Section: Discussionsupporting

confidence: 74%

“…On the other hand, when the effect was severe or persistent despite the symptomatic treatment a change of antiretroviral molecule was made. Similar results have been described in the literature [19,23,40]. We used the WHO causality score of adverse drug reactions to assess antiretroviral related causality.…”

Section: Discussionmentioning

confidence: 63%

“…Tuberculosis was most prevalent in patients without ADR. Khalili et al, found cases of co-infections with tuberculosis in 8% [19]; Modayil et al in 2010 found 39.7% of cases of co-infections with tuberculosis [23]. Tuberculosis is a pathology that could be associated and be an additional risk.…”

Section: Discussionmentioning

confidence: 99%

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Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Oumar¹,

Abdoulaye²,

Maiga³

et al. 2017

J Pharmacovigilance

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Objective: The purpose of this study was to evaluate the adverse effects of Antiretroviral Therapy (ART) in adult HIV-infected patients in decentralized setting of Sikasso, in Mali.Methods: This is a proactive study that took place from 2 January 2011 to 30 December 2012 at the Hospital of Sikasso (Department of Medicine). HIV-infected adult patients who have started ART at least 3 months before were included in this study to monitor the laboratory and clinical Adverse Drug Reactions (ADR) for at least 6 months. The WHO classification of adverse drug reactions has been used to investigate the causality of antiretrovirals.Results: Women were the most represented with 58% of the cases. The most represented age range was 26-47 years with 73.6%. Of the 178 patients enrolled, 61.2% had an ADR. ADR were neurological (40.4%), digestive (35.8%), cutaneous (18.3%) and hematological (5.5%). Stavudine was the most incriminated molecule, in 24.8% of the cases. The WHO grade 4 classification of ART toxicity was represented in 3.4% of the cases. The WHO causality score of "certain" was found in 29.8% of the cases. Conclusion:Adverse effects of Antiretrovirals are frequent and could be life-threatening in short and long terms. Regular follow-up of patients receiving these triple therapies, and the associated complications, is essential. We recommend active surveillance of antiretroviral therapy to strengthen Pharmacovigilance in Mali.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 63%

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Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Oumar¹,

Abdoulaye²,

Maiga³

et al. 2017

J Pharmacovigilance

View full text Add to dashboard Cite

show abstract

“…In contrast, most of the previous studies result in higher prevalence of ADRs among female than male patients [17][18][19], however the observation support the result of higher prevalence rate of ADRs in age group 31-50 years of patients [17,20]. The results of ours study may be due to majority of the male patients in the current study.…”

Section: Discussioncontrasting

confidence: 57%

Gender Differences in Adverse Drug Reactions during HAART Therapy in HIV/AIDS Patients at a Tertiary Care Hospital Penang, Malaysia

Khan¹,

Khan²,

Sulaiman³

et al. 2017

J AIDS Clin Res

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“…Unfortunately adverse effects of these drugs are of serious concern. 6 The introduction of HAART has led to a signifi cant reduction in AIDS related morbidity and mortality. Unfortunately, up to 25% of all patients discontinue their initial HAART regimen because of treatment failure, toxic effects or noncompliance within the fi rst 8 months of therapy.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Observational Study of Adverse Drug Reactions to Antiretroviral Therapy: Type and Risk Factors in a Tertiary Care Teaching Hospital.

Krishnaswamy

Hema

Sangeetha³

2014

Int J Basic Clin Pharmacol

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Adverse drug reactions to antiretroviral therapy (ART): an experience of spontaneous reporting and intensive monitoring from ART centre in India

Abstract: Prevalence of ADRs in intensively monitored patients was found to be 39.7%. Tuberculosis in HIV patients is an influential risk factor for occurrence of ADRs. With the increasing access to antiretrovirals in India, ADRs to antiretrovirals require monitoring and reporting.

Cited by 47 publications

References 34 publications

Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Gender Differences in Adverse Drug Reactions during HAART Therapy in HIV/AIDS Patients at a Tertiary Care Hospital Penang, Malaysia

A Prospective Observational Study of Adverse Drug Reactions to Antiretroviral Therapy: Type and Risk Factors in a Tertiary Care Teaching Hospital.

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