Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Oumar, Aboubacar Alassane; Abdoulaye, Amadou; Maiga, Mamoudou; Sidibe, Younoussa; Cissoko, Yacouba; Konaté, Issa; Diarra, Maimouna; Sangho, F; Dembélé, Jean Paul; Tulkens, Paul M.; Dao, Sounkalo

doi:10.4172/2329-6887.1000228

Cited by 10 publications

(18 citation statements)

References 21 publications

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“…P value of less than 0.05 was taken as significant. 8 in 2014 also not observed any significant difference in ADR between male (50.6%) and female (49.4%) in their study.…”

Section: Discussionmentioning

confidence: 61%

A Study on Adverse Drug Reactions in Patients on Antiretroviral Therapy in a Tertiary Care Hospital at Jaipur, Rajasthan

Gupta

Agarwal

2021

IJMBS

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Background: The present study was conducted to know the status of ADRs caused due to the first line ART in the ART center of SMS Hospital Jaipur, Rajasthan. This study would be beneficial to the HIV infected patients, with the ultimate goal of improving the tolerability and effectiveness of HIV treatment by promoting the early recognition of potentially serious adverse effects. Methods: Hospital based Prospective, Observational study conducted after approval by research review board and ethics committee SMS Medical College Jaipur (Rajasthan). WHO definition of ADR was used (any response to a medicine which is noxious and unintended and which occurs at doses normally used in man). The detail of ADRs collected including suspected drug involved, treatment given for ADRs and outcome. Results: Majority of ADRs were related to central and peripheral nervous system related 55 (47%) followed by gastro intestinal 28 (23.9%), dermatological 15 (12.8%), musculoskeletal 9 (7.7%) and metabolic 5 (4.3%). Conclusion: Majority of ADRs were related to central and peripheral nervous system related followed by gastro intestinal. Keywords: ADRs, HIV, WHO.

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“…P value of less than 0.05 was taken as significant. 8 in 2014 also not observed any significant difference in ADR between male (50.6%) and female (49.4%) in their study.…”

Section: Discussionmentioning

confidence: 61%

A Study on Adverse Drug Reactions in Patients on Antiretroviral Therapy in a Tertiary Care Hospital at Jaipur, Rajasthan

Gupta

Agarwal

2021

IJMBS

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“…This pattern of manifestation was similar to findings reported from several studies. 10,11,20,33,34,36 It is also worthy to note that this pattern of ADRs reported was similar to the common side effects associated with major HAART regimen used by most of the patients (zudovudine + Lanuvudine +Nevirapine). There is a likelihood that some mild ADRs may not have been reported by the patients nor found by the researchers due to their similarity with the symptoms and signs of HIV infection which further supports the low prevalence rate reported from the study.…”

Section: Discussionmentioning

confidence: 52%

Prevalence and Pattern of Adverse Drug Reactions among HIV Infected Patients on Highly Active Antiretroviral Therapy (HAART) in Imo State, Nigeria: A Hospital Based Survey

Chioma

Chukwuma

Chinomnso

2019

J. Drug Delivery Ther.

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Introduction: It is a proven fact that almost all drugs carry the potential to produce undesirable effects in addition to the desired ones. Aim: The aim of this study is to determine the prevalence, pattern and socio-demographic determinants of adverse drug reactions among patients on HAART attending clinics in hospitals in Imo State Nigeria. Methodology: This was a hospital-based cross-sectional study carried out among HIV patients attending clinics in hospitals in Imo State. The 400 participants were selected using a multistage sampling technique. Data was collected using an interviewer administered, semi-structured questionnaire and analyzed using EPI Info version 3:2:1. Chi-square and regression analysis was used to test association between variables. P-value was set at ≤ 0.05. Results: The mean age of the participants was 41.7±3.0 years with a male to female ration of 1:2. The adherence level to HIV treatment was 85.0%. The prevalence of ADRs in the last 1 year preceding the study was 13.7% and the common forms of ADR experienced by patients was Hematological symptoms (34%), GIT symptoms (21.8%) and skin manifestation (20.0%). Socio-demographic determinants of the occurrence of ADR among the participants were: age 50 years and above (OR: 9.28), female gender (OR: 2.55) and living in a rural area (OR: 4.47). Conclusion: Though the prevalence of ADR reported in this study was low, there is need to increase the depth of knowledge among HIV patients in the State, monitor patients closely by care givers and find possible ways to increase adherence to HIV drugs which was not optimal among participants. Keywords: Prevalence, Pattern, Adverse Drug reactions, HAART, HIV, Patients, Imo State.

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“…Based on our finding, the risk of ADR among patients from rural areas were higher than patients from urban. Similarly, the proportion of ADR were higher at the rural on the studies conducted at Mali [ 8 ]. Even though studies were conducted in different setting in Ethiopia, residency was not significantly associated with ADR.…”

Section: Discussionmentioning

confidence: 99%

Predictors of adverse drug reaction among adult HIV-infected patients on antiretroviral therapy in government hospitals of Kaffa Zone, Ethiopia; November 2018: a retrospective cohort

Mitkie¹,

Belayneh²,

Debiso³

2021

Pan Afr Med J

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Introduction incidence of adverse drug reactions (ADR) associated with antiretroviral therapy (ART) was higher in developing countries. In two teaching hospital in Ethiopia: Debremarkose 23% and Yirgalem 73.2% of study participants reported at least one ADR. Since there was limited information about ADR in the study area; we aimed to determine its incidence-rate and predictors. Methods we conducted retrospective cohort study using medical records of HIV-infected patients enrolled on ART between 2006 and 2017 in government hospitals of Ethiopia. ADR was defined as report of at least one unwanted response to ART. We run descriptive and cox regression analysis (CRA). Results incidence-rate of ADR was 4.1 per 100 person-years (py). Hazards of ADR among patients living at rural was almost two times than at urban; [Adjusted hazard ratio (AHR): 1.94(95% (CI): 1.18, 3.20)]. Stavudine (D4T)-Lamivudine (3TC)-Nevirapine (NVP) had about two times [AHR: 1.78(95%CI: 1.03, 3.08)], Zidovudine(AZT)-3TC-NVP had about two times [AHR: 2.34 (95%CI: 1.20, 4.57)], D4T-3TC-Efaviranze(EFV) had about three times [AHR: 2.86(95%CI: 1.38, 5.95)] and AZT-3TC-EFV had about two times [AHR: 2.16(95%CI: 1.21,3.90)] hazards of ADR than Tenofovir(TDF) based regimens. Being WHO clinical stage III had about two times hazard of ADR [AHR: 2.46 (95%CI: 1.22, 4.95)] and IV had about four times hazard of ADR [AHR: 4.32 (95%CI: 1.88, 9.93)] than stage I. Conclusion risk of ADR was higher among adult HIV-infected patients on ART living in rural, WHO clinical stage III and IV, and patients on AZT and D4T based regimen. AZT should not be given as an alternative treatment, increase access of TDF regimens.

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Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Cited by 10 publications

References 21 publications

A Study on Adverse Drug Reactions in Patients on Antiretroviral Therapy in a Tertiary Care Hospital at Jaipur, Rajasthan

A Study on Adverse Drug Reactions in Patients on Antiretroviral Therapy in a Tertiary Care Hospital at Jaipur, Rajasthan

Prevalence and Pattern of Adverse Drug Reactions among HIV Infected Patients on Highly Active Antiretroviral Therapy (HAART) in Imo State, Nigeria: A Hospital Based Survey

Predictors of adverse drug reaction among adult HIV-infected patients on antiretroviral therapy in government hospitals of Kaffa Zone, Ethiopia; November 2018: a retrospective cohort

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