Adverse effect of Nitroxynil and Albendazole on rabbits

Abstract

The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits. Design: Randomized controlled experimental study. Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6). Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1 st , 7 th and 14 th days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed. Results:The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A.