Adverse effect of splenectomy on growth and survival withmurine lymphosarcoma

Mollitt, Daniel L.; Malangoni, Mark A.; Thomas, Vinod; Grosfeld, Jay L.

doi:10.1016/s0022-3468(82)80011-0

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Meanwhile, numerous studies have been done to explore the role of the spleen in immunological regulation for immune response in tumor-bearing hosts [7,8] and in evaluating the effect of splenectomy on the growth of tumor without satisfactory conclusion. Splenectomy has been shown to enhance [9,10], inhibit [11,12], or to have no effect on [13,14] Several reasons have been offered to explain these differences [15,16], but so far the exact mechanisms for enhanced or retarded tumor growth in splenectomized subjects remain obscure.…”

Section: Introductionmentioning

confidence: 99%

Changes of peripheral t‐cell subsets in asplenic w256 tumor‐bearing rats

Han

Xiantao

1989

Journal of Surgical Oncology

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In exploring the mechanism of the effect of splenectomy on tumor growth, splenectomized rats and other control rats were implanted subcutaneously with Walker 256 carcinosarcoma cells (5 x 10(5] on day 10 after splenic operation; meanwhile, peripheral T-lymphocyte subsets were analysed successively. It was found that splenectomy enhanced the rate of tumor appearance and mean tumor diameter and disturbed the equation of T-lymphocyte subsets in peripheral blood, i.e., a subnormal level of Th/Ts ratio. Interestingly, a significant correlation was noted between decreasing values of Th/Ts ratio and increasing average diameters of implanted tumor in splenectomized rats, but not in sham-splenectomized or nonoperated rats with tumor growth. In spleen cells from tumor-bearing rats, a distinct increase of B-lymphocytes and a decrease of T cells were demonstrated. Data from this investigation provide striking evidence that a relationship exists between enhancement of tumor growth and disproportion of T-lymphocyte subsets in peripheral blood and offer some reasonable explanation for the causes of the promotive role of tumor growth following splenectomy.

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