Adverse effects in broiler chickens fed a high lycopene concentration supplemented diet

Pozzo, Luisa; Tarantola, Martina; Biasibetti, Elena; Capucchio, Maria Teresa; Pagella, Maddalena; Mellia, Elisabetta; Bergagna, Stefania; Gennero, Maria Silvia; Strazzullo, G.; Schiavone, Achille

doi:10.4141/cjas2012-081

Cited by 13 publications

(13 citation statements)

References 35 publications

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“…The results of this study revealed that dietary lycopene did not significantly improve production performance rates. This result is in accordance with the results obtained by Pozzo et al (2013). Interestingly, fertilization rates and hatchability of eggs set significantly (P < 0.05) increased with lycopene supplementation.…”

Section: Discussionsupporting

confidence: 82%

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Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Sun¹,

Ma²,

Zhang³

et al. 2014

Czech J. Anim. Sci.

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ABSTRACT:Lycopene is a carotenoid present in vegetables and ripe fruit and has been proved to be the most potent antioxidant among various common carotenoids. This study assessed the effects of lycopene on performance production, tissue lycopene content, antioxidant capacity, and biochemical parameters in 720 Xing-hua breeding hens. Rice-soybean diets were supplemented with different lycopene levels: 0, 20, 40, and 80 mg/kg. Lycopene supplementation significantly increased fertilization rates in hens. Serum and egg lycopene contents and the Roche Yolk Colour Fan score increased with lycopene supplementation through day 7. In the liver, lycopene supplementation significantly increased superoxide dismutase (SOD), total antioxidant capacity (T-AOC), and reduced glutathione to oxidized glutathione ratio (GSH/GSSG). Additionally, lycopene supplementation increased serum SOD, serum T-AOC, serum glutathione peroxidase, and serum GSH/GSSG. Lycopene addition significantly decreased total cholesterol and increased high density lipoprotein cholesterol and triiodothyroxine. It also improved fertilization rates, antioxidant capacity, and metabolism in breeding hens.

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Section: Discussionsupporting

confidence: 82%

“…Findings from other studies reveal that lycopene improves the lipid profile of chickens (Sevcikova et al 2008). Meanwhile, negative effects of high doses of lycopene have been found in broiler chickens (Pozzo et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Sun¹,

Ma²,

Zhang³

et al. 2014

Czech J. Anim. Sci.

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“…Growth performance is an indispensable indicator of poultry growth status under different conditions ( 21 ), and the lycopene could improve chicken performance ( 22 , 23 ). In the present study, the ADG increased, and the FCR decreased in groups treated with lycopene in the grower and whole phases, and the ADFI was quadratically affected by lycopene in the grower phase, which was consistent with Mezbani's study ( 22 ), who reported that chicken supplemented with 100 mg/kg lycopene from 21 to 42 days resulted in the increased body weight and decreased feed conversion ratio.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lycopene on the Growth Performance, Antioxidant Enzyme Activity, and Expression of Gene in the Keap1-Nrf2 Signaling Pathway of Arbor Acres Broilers

Wang

Zhu

et al. 2022

Front. Vet. Sci.

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The objective of this study was to determine the effect of dietary lycopene supplementation on the growth performance, antioxidant enzyme activity of serum and liver, and gene expressions associated with Kelch-like ech-associated protein-1 (Keap1)/Nuclear Factor E2-related factor 2 (Nrf2) pathway in liver of Arbor Acres broilers. A total of 288 1-day-old male broilers were randomly divided into 4 treatments with 6 replicates and 12 chickens for each replicate. The control group was fed with the basal diet, while the treated groups were fed with the basal diet with 10, 20, and 30 mg/kg lycopene in powder. Feed and water were provided ad libitum for 42 days. Compared with the control group, (a) the average daily gain increased (p = 0.002 vs. p = 0.001) and the feed conversion ratio decreased (p = 0.017 vs. p = 0.023) in groups treated with lycopene in the grower and whole phases, and the average daily feed intake was quadratically affected (p = 0.043) by lycopene in the grower phase; (b) the serum superoxide dismutase content was linearly affected (p = 0.035) by lycopene at 21 days; (c) the serum glutathione peroxidase content, superoxide dismutase content, and total antioxidant capability were higher (p = 0.014, p = 0.003, and p = 0.016, respectively) in the 30 mg/kg lycopene group at 42 days; (d) the liver glutathione peroxidase and superoxide dismutase contents in groups treated with lycopene were higher (p ≤ 0.001 vs. p ≤ 0.001) at 21 days; (e) the liver glutathione peroxidase content was higher (p ≤ 0.001) in the 20 and 30 mg/kg lycopene groups, at 42 days; (f) the mRNA expression levels of Nrf2, superoxide dismutase 2, NAD(P)H quinone dehydrogenase 1, and heme oxygenase 1 genes were higher (21 days: p = 0.042, p = 0.021, p = 0.035, and p = 0.043, respectively; 42 days: p = 0.038, p = 0.025, p = 0.034, and p = 0.043, respectively) in the 20 and 30 mg/kg lycopene groups at 21 and 42 days. The 30 mg/kg lycopene concentration improved the growth performance, antioxidant enzyme activity in serum and liver, and gene expression in the Keap1-Nrf2 signaling pathway of Arbor Acres broilers.

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“…For example, Sevcikova et al ( 2008 ) reported that dietary LP at 100 mg/kg of diet, but not at 50 mg/kg of diet, significantly increased the body weight in broiler chickens compared with those fed the LP-free diet. On the other hand, dietary LP failed to affect growth performance of broiler chickens fed diet containing tomato skin extracts, which contained 200 mg of LP per kg of diet (Marzoni et al 2014 ), or LP at 500 ppm (Pozzo et al 2013 ). Leal et al ( 1999 ) reported that LP feeding reversed the T-2 toxin-induced depression in feed intake and weight gain in chicken.…”

Section: Discussionmentioning

confidence: 99%

“…The latter finding explains the failure to find the presence of LP in leg meats compared with that in liver and plasma as shown in this study. Nonetheless, Pozzo et al ( 2013 ) reported that trace amounts of LP were detected in breast (0.10 mg/kg of fresh weight) and thigh meats (0.42 mg/kg of fresh weight) of broiler chickens fed LP-added diet at the level of 500 mg. Due to the lack of studies measuring LP in poultry meats, further studies with graded levels of LP are warranted to prove the observed differences. In contrast, the presence of LP in serum and liver has been well established in poultry (Sahin et al 2006 ; Englmaierova et al 2011 ; Sun et al 2014a , 2015 ), which corroborates well with our current study.…”

Section: Discussionmentioning

confidence: 99%

Effect of lycopene on the copper-induced oxidation of low-density lipoprotein in broiler chickens

et al. 2016

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The present study was undertaken to investigate whether dietary lycopene (LP) could prevent the copper-mediated oxidation of low density lipoprotein (LDL), and affect growth performance, relative organ weights, plasma and meat lipid profiles, and LP contents in plasma and tissues in broiler chickens. A total of 160 day-old male broiler chicks were randomly allotted into 16 pens with rice husk as a bedding material. Each experiment had 4 replicates, 10 chicks per replicate (n = 4 per treatment). A corn-soybean meal base diet was used as a control diet (CONT). To formulate the experimental diets, the base diet was added with LP at the levels of 10 (LP10) or 20 mg/kg (LP20), or 17 g/kg of tomato paste (TP17) which was equivalent to 5 ppm of LP. The experiment lasted 4 weeks. Growth performance and relative organ weights were not affected (p > 0.05) by any of dietary treatments. Dietary LP significantly lowered (p < 0.05) triglyceride and LDL cholesterol at 2 weeks of age, but did not affect them at 4 weeks of age. Total cholesterol in thigh meats was not altered by dietary treatments. LP was not detected in leg meats in all chicks, nor in liver or plasma of the CONT group. LP was found in liver and plasma, being the former greater in the concentration, of the chicks fed diets containing LP10, LP20, or TP17. At 2 and 4 weeks, the copper-mediated oxidation of LDL was delayed (p < 0.05) in either LP- or TP-fed chickens compared with the CONT group. In conclusion, LP lowers triglyceride and LDL cholesterol, is deposited into serum and liver, and prevents the LDL oxidation in broiler chickens, confirming the role of LP in the lipid-lowering and antioxidant properties in broiler chickens.

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Adverse effects in broiler chickens fed a high lycopene concentration supplemented diet

Cited by 13 publications

References 35 publications

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Lycopene regulates production performance, antioxidant capacity, and biochemical parameters in breeding hens

Effect of Lycopene on the Growth Performance, Antioxidant Enzyme Activity, and Expression of Gene in the Keap1-Nrf2 Signaling Pathway of Arbor Acres Broilers

Effect of lycopene on the copper-induced oxidation of low-density lipoprotein in broiler chickens

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