Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation

Menale, Ciro; Mita, Damiano Gustavo; Diano, Nadia; Diano, Sabrina

doi:10.2174/1874070701610010122

Cited by 16 publications

(5 citation statements)

References 54 publications

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“…BPA has an important role in endocrine adipose tissue function by an effect on the secretion of leptin and adiponectin (Menale, Mita, Diano, & Diano, 2016). Leptin, a hormone produced by adipose cells, by influence on the central nervous system and hypothalamus, has a main role in regulating body weight.…”

Section: Effect Of Bpa Resveratrol and Gse On Lipid Profile And Omentioning

confidence: 99%

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Rameshrad

Razavi

Imenshahidi

et al. 2019

Phytotherapy Research

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The mechanisms of bisphenol‐A (BPA)‐induced metabolic syndrome as well as the protective role of grape seed extract (GSE) and resveratrol were investigated. Rats were treated with BPA (0 and 35 mg·kg−1·day−1, gavage) plus resveratrol (25, 50, and 100 mg·kg−1·day−1, i.p.) or GSE (3, 6, 12 mg·kg−1·day−1, i.p.) or vitamin E (200 IU/kg/every other day, i.p.). After 2 months, mean systolic blood pressure, serum lipid profile, glycaemia, and fat index were examined. By enzyme‐linked immunosorbent assay, the serum concentrations of insulin, leptin, adiponectin, and paraoxonase 1, and by real‐time polymerase chain reaction as well as western blotting, key liver elements in cholesterol hemostasis (LDLR, CYP7A1, ABCG5 and 8) and insulin signaling (p‐Akt/Akt and p‐PI3K/PI3K) were measured. BPA increased mean systolic blood pressure, total cholesterol, and low‐density lipoprotein cholesterol and reduced paraoxonase1 and the hepatic expression of both ABCG5 and ABCG8. It increased the body fat index, leptin, adiponectin, insulin, and glycaemia level and decreased the hepatic protein expression of p‐Akt/Akt and p‐PI3K/PI3k. GSE, resveratrol, or vitamin E coadministration along with BPA restored the detrimental effects of BPA in some levels. Herein, the predisposing effects of BPA‐induced metabolic syndrome were restored by GSE and resveratrol, linked to the regulation of insulin signaling, ABCG8 expression, and their antioxidant properties.

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Section: Effect Of Bpa Resveratrol and Gse On Lipid Profile And Omentioning

confidence: 99%

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Rameshrad

Razavi

Imenshahidi

et al. 2019

Phytotherapy Research

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“…Our results thus connect several crucial active metabolic pathways, identified in single myeloid lineages, while also displaying their unique combination for each lineage, as well as their inactivity in the other lineages. Direct usability for hematotoxicity studies is evident, as several xenobiotic compounds are known to selectively interact with specific metabolic pathways [101][102][103]. Likewise, elucidation of effects by endogenous compounds on hematopoiesis can also be achieved by usage of the here presented model, which may ultimately result in new therapy approaches.…”

Section: Discussionmentioning

confidence: 93%

Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways

Kaiser

Weinschrott

Quint

et al. 2020

IJMS

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Assessment of hematotoxicity from environmental or xenobiotic compounds is of notable interest and is frequently assessed via the colony forming unit (CFU) assay. Identification of the mode of action of single compounds is of further interest, as this often enables transfer of results across different tissues and compounds. Metabolomics displays one promising approach for such identification, nevertheless, suitability with current protocols is restricted. Here, we combined a hematopoietic stem and progenitor cell (HSPC) expansion approach with distinct lineage differentiations, resulting in formation of erythrocytes, dendritic cells and neutrophils. We examined the unique combination of pathway activity in glycolysis, glutaminolysis, polyamine synthesis, fatty acid oxidation and synthesis, as well as glycerophospholipid and sphingolipid metabolism. We further assessed their interconnections and essentialness for each lineage formation. By this, we provide further insights into active metabolic pathways during the differentiation of HSPC into different lineages, enabling profound understanding of possible metabolic changes in each lineage caused by exogenous compounds.

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“…The EDC with the biggest volume of production worldwide is BPA, with an emission rate of about 100 tons annually. Being the primary monomer in polycarbonate plastics, it is widely used and can enter the body orally and topically [17]. Various pieces of evidence suggest that BPA may be hazardous to human health, particularly for endocrine metabolism, including, but not limited to, glucose homeostasis [18][19][20].…”

Section: Endocrine Disrupting Chemicals (Edcs) As a Contributing Fact...mentioning

confidence: 99%

Endocrine disrupting chemicals: gestational diabetes and beyond

Mitra,

Gulati,

Ramachandran

et al. 2024

Diabetol Metab Syndr

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Gestational Diabetes Mellitus (GDM) has been on the rise for the last two decades along with the growing incidence of obesity. The ubiquitous use of Endocrine-Disrupting Chemicals (EDCs) worldwide has been associated with this increase in GDM incidence. Epigenetic modifications such as DNA methylation, histone acetylation, and methylation have been associated with prenatal exposure to EDCs. EDC exposure can also drive a sustained disruption of the hypothalamus-pituitary-thyroid axis and various other signaling pathways such as thyroid signaling, PPARγ signaling, PI3K-AKT signaling. This disruption leads to impaired glucose metabolism, insulin resistance as well as β-cell dysfunction, which culminate into GDM. Persistent EDC exposure in pregnant women also increases adipogenesis, which results in gestational weight gain. Importantly, pregnant mothers transfer these EDCs to the fetus via the placenta, thus leading to other pregnancy-associated complications such as intrauterine growth restriction (IUGR), and large for gestational age neonates. Furthermore, this early EDC exposure of the fetus increases the susceptibility of the infant to metabolic diseases in early life. The transgenerational impact of EDCs is also associated with higher vascular tone, cognitive aberrations, and enhanced susceptibility to lifestyle disorders including reproductive health anomalies. The review focuses on the impact of environmental toxins in inducing epigenetic alterations and increasing the susceptibility to metabolic diseases during pregnancy needs to be extensively studied such that interventions can be developed to break this vicious cycle. Furthermore, the use of EDC-associated ExomiRs from the serum of patients can help in the early diagnosis of GDM, thereby leading to triaging of patients based on increasing risk factor of the clinicopathological condition.

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Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation

Cited by 16 publications

References 54 publications

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways

Endocrine disrupting chemicals: gestational diabetes and beyond

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