Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation

Abstract

Bisphenol A (BPA) is used as basic chemical compound in the production of polycarbonate food containers or epoxy resins coating metallic cans for food and beverages conservation. Its xenoestrogenic activity alters endocrine-metabolic pathways modulating glucose metabolism and increasing the risk of developing diabetes, insulin resistance, and obesity. Based on in vitro and in vivo experimental research, here we report some of the major BPA adverse effects on tissues that play a key role in the regulation on the whole body's metabolism. Evidences have shown that BPA is able to exert its endocrine disrupting action altering glucose metabolism and contributing to the onset of metabolic disorders, acting on liver functions and affecting insulin production by the pancreas. Exposure to BPA has been reported also to modulate glucose utilization in muscles, as well as to interfere with adipose tissue endocrine function. In addition, to peripheral tissues, recent studies have shown that BPA by acting in the Central Nervous System affects neuroendocrine regulation of glucose metabolism, promoting glucose metabolism dysfunction such as glucose intolerance and insulin resistance. Thus, exposure to BPA seems to be an important risk factor in the onset of obesity and metabolic syndrome.However, its mechanisms of action need to be further investigated to provide a major evaluation of risk assessment.

Metabolite patterns in human myeloid hematopoiesis result from lineage-dependent active metabolic pathways

“…Direct usability for hematotoxicity studies is evident, as several xenobiotic compounds are known to selectively interact with specific metabolic pathways. [81][82][83] Likewise, elucidation of effects by endogenous compounds on hematopoiesis can also be achieved by usage of the here presented model, which may ultimately result in new therapy approaches. Furthermore, our results enable improved interpretation of metabolic alterations, observed by different compounds.…”

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

“…BPA has an important role in endocrine adipose tissue function by an effect on the secretion of leptin and adiponectin (Menale, Mita, Diano, & Diano, ). Leptin, a hormone produced by adipose cells, by influence on the central nervous system and hypothalamus, has a main role in regulating body weight.…”

Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways

“…Our results thus connect several crucial active metabolic pathways, identified in single myeloid lineages, while also displaying their unique combination for each lineage, as well as their inactivity in the other lineages. Direct usability for hematotoxicity studies is evident, as several xenobiotic compounds are known to selectively interact with specific metabolic pathways [ 101 , 102 , 103 ]. Likewise, elucidation of effects by endogenous compounds on hematopoiesis can also be achieved by usage of the here presented model, which may ultimately result in new therapy approaches.…”