Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters

Helal, Eman G.E.; Almutairi, Aisha; Abdelaziz, Mohamed A.; Mohamed, Abdullah Sani

doi:10.21608/ejhm.2020.104304

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…The present study showed a decrease in glycogen content as appeared in the decreased percentage of PAS stained in rat treated with NaNo3 that result agreed with Helal et al [33] stated that the existence of nitrate ions leads to the release of glucose from glycogen, so blood glucose rises while hepatic glycogen diminishes. The administration of honey and ascorbic acid in the NaNO3-treated group increased the glycogen content as appeared by the increased percentage of PAS stained.…”

Section: ------------------------------------------------------------...supporting

confidence: 92%

Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats

Kamel¹,

Mahmoud²,

El-Hak³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Sodium nitrate has been used extensively as a meat additive to keep meat products fresh. Several strategies have been implemented in counteracting such toxicity. Objective: The goal of the current investigation was to determine if ascorbic acid and crude honey extract can protect male rats from the harmful biochemical and histopathological effects of sodium nitrate. Materials and methods: 36 male Albino rats were alienated into 6 groups; control was given saline, honey group was given (2.5g/kg/day honey, ascorbic group was given (200mg/kg /day) L-ascorbic acid, NaNO3 group was given 200mg/kg/day, honey/ NaNO3 group rats given honey and nitrate with the former doses, and Ascorbic/ NaNO3 group was given L-ascorbic acid and NaNO3 with the former doses. Organs' relative weight, liver and kidney blood biochemical determinants, serum tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), histology and histochemistry were determined. Results: The sodium nitrate had significantly increased liver, kidney and spleen relative weights while decreased thymus weight. Higher levels of AST, ALT, urea, creatinine, IL-6 and TNF-α were observed in NaNO3 treated group. Liver, kidney, and spleen of rats treated with NaNO3 revealed histological and histochemical alterations. The treatment with L-ascorbic acid and crude honeybee improved the later dysfunctions with more palliative effect for L-ascorbic acid. Conclusions: We can conclude that sodium nitrate has to be limited in use. L-ascorbic acid was therefore recommended to be used in reducing the harmful metabolic alterations induced by sodium nitrate better than the honeybee.

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confidence: 92%

Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats

Kamel¹,

Mahmoud²,

El-Hak³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…However, TG and HDL-C levels decreased significantly in NaNO2-treated rats, compared to the control group (Figure 6). These findings aligned with several reports that showed that NaNO2 administration increases urea and creatinine levels (Khalil, 2016;Helal et al, 2020). The observed elevation in markers of kidney function (urea, uric acid, and creatinine) suggests renal failure in NaNO2-treated rats (Johnson et al, 2013).…”

Section: Assessment Of Scree Impact On Kidney Function and Lipid Profilesupporting

confidence: 91%

“…The notable toxic properties of nitroso derivatives, which form in the acidic environment of the stomach and cause severe liver necrosis, could be the cause of elevated liver enzyme activity (Chain et al, 2023). In addition, elevated AST and ALT activities in the NaNO2-treated group could be related to the nitric oxide-induced free radical (ONOO-) (Helal et al, 2020). Both oxygen radicals and NO possess the potential to react further to produce other oxidants and nitro substances, such as peroxynitrite, which can be harmful to the liver and contribute to liver cell death.…”

Section: Assessment Of the Impact Of Scree On Liver Functionmentioning

confidence: 99%

Supplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis

Elshaer,

Hamad,

Sobhy

et al. 2024

Front. Pharmacol.

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Sodium nitrite (NaNO2) is a widely used food ingredient, although excessive concentrations can pose potential health risks. In the present study, we evaluated the deterioration effects of NaNO2 additives on hematology, metabolic profile, liver function, and kidney function of male Wistar rats. We further explored the therapeutic potential of supplementation with S. costus root ethanolic extract (SCREE) to improve NaNO2-induced hepatorenal toxicity. In this regard, 65 adult male rats were divided into eight groups; Group 1: control, Groups 2, 3, and 4 received SCREE in 200, 400, and 600 mg/kg body weight, respectively, Group 5: NaNO2 (6.5 mg/kg body weight), Groups 6, 7 and 8 received NaNO2 (6.5 mg/kg body weight) in combination with SCREE (200, 400, and 600 mg/kg body weight), respectively. Our results revealed that the NaNO2-treated group shows a significant change in deterioration in body and organ weights, hematological parameters, lipid profile, and hepatorenal dysfunction, as well as immunohistochemical and histopathological alterations. Furthermore, the NaNO2-treated group demonstrated a considerable increase in the expression of TNF-α cytokine and tumor suppressor gene P53 in the kidney and liver, while a significant reduction was detected in the anti-inflammatory cytokine IL-4 and the apoptosis suppressor gene BCL-2, compared to the control group. Interestingly, SCREE administration demonstrated the ability to significantly alleviate the toxic effects of NaNO2 and improve liver function in a dose-dependent manner, including hematological parameters, lipid profile, and modulation of histopathological architecture. Additionally, SCREE exhibited the ability to modulate the expression levels of inflammatory cytokines and apoptotic genes in the liver and kidney. The phytochemical analysis revealed a wide set of primary metabolites in SCREE, including phenolics, flavonoids, vitamins, alkaloids, saponins and tannins, while the untargeted UPLC/T-TOF–MS/MS analysis identified 183 metabolites in both positive and negative ionization modes. Together, our findings establish the potential of SCREE in mitigating the toxic effects of NaNO2 by modulating metabolic, inflammatory, and apoptosis. Together, this study underscores the promise of SCREE as a potential natural food detoxifying additive to counteract the harmful impacts of sodium nitrite.

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Root extracts of Saussurea costus as prospective detoxifying food additive against sodium nitrite toxicity in male rats

Elshaer

Hamad

Hafez

et al. 2022

Food and Chemical Toxicology

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Adverse Effects of Fast Green, Sodium Nitrate and Glycine on Some Physiological Parameters

Cited by 3 publications

References 15 publications

Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats

Comparative Protective Effects of L-Ascorbic Acid and Crude Honeybee Extract Supplements Against Toxic Effects Induced by Sodium Nitrate in Male Rats

Supplementation of Saussurea costus root alleviates sodium nitrite-induced hepatorenal toxicity by modulating metabolic profile, inflammation, and apoptosis

Root extracts of Saussurea costus as prospective detoxifying food additive against sodium nitrite toxicity in male rats

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