Root extracts of Saussurea costus as prospective detoxifying food additive against sodium nitrite toxicity in male rats

Elshaer, Samy E.; Hamad, Gamal M.; Hafez, Elsayed E.; Baghdadi, Hoda H.; El‐Demerdash, Fatma M.; Simal-Gándara, Jesús

doi:10.1016/j.fct.2022.113225

Cited by 18 publications

(14 citation statements)

References 45 publications

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“…Who determined the Rutin, Kaempferol, and Catechin in a concentration of 5.39, 16.8, and 0.0 mg/kg, respectively. In contrast, these results disagree with results reported previously [27], which found Kaempferol, Catechine, and Rutin at 0.0 mg/kg concentration by the ethanolic extract.…”

Section: Phenolic Compound Of the Scostus Roots Extractcontrasting

confidence: 99%

Extraction and Evaluation of Active Ingredients of Saussurea costus Roots and Determination of its Antibacterial Activity

Al-Zayadi,

Shanan,

Salihi

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Saussurea costus (Sc) plant belongs to the Asteraceae family. It contains various bioactive compounds used traditionally in treating multiple diseases. This study intends to extract and evaluate the active ingredients of Sc roots (Scrs) and determine their antibacterial activities. S. costus roots were purchased from the herbal market and the chemical compositions, including protein, lipid, carbohydrates, moisture, and ash, were determined according to AOAC procedures 2016 with some modifications. HPLC and amino acids analyzer were used to determine the phenolic compounds and amino acid composition of S. costus roots extract (ScrsE). The antibacterial activities of S. costus roots extract were done according to the Kirby-Bauer disc diffusion method. The S. costus roots were revealed a fusiform (or) conical and tapering appearance, collapsing in the centre with longitudinal wrinkles revealing 11-19 cm and 1-2.5 cm for long and wide, respectively. The extraction yield was 9.52% and the weight of the concentrated crude extract was 10 g. According to Proximate analysis, the S. costus roots extract showed 3.88% and 20.12% moisture and ash contents, respectively. The compositions of carbohydrates, protein, and crude fat were 75.25%, 2.51%, and 1.85%, respectively. HPLC analysis showed that the S. costus roots Extract contained two phenolic acids and two flavonoids. Moreover, twelve amino acids were determined for the first time in the S. costus roots extract. Various antibacterial activities were seen with maximum inhibition zone for Streptococcus pyogenes & E.coli; and minimum for Bacillus subtilis & Pseudomonas aeruginosa. In conclusion, this study investigated various contents of S. costus roots extract including amino acids, carbohydrates, protein, and crude fat, in addition to its antibacterial activities. The authors recommend more future studies to investigate the therapeutic activities of S. costus roots extract.

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Section: Phenolic Compound Of the Scostus Roots Extractcontrasting

confidence: 99%

Extraction and Evaluation of Active Ingredients of Saussurea costus Roots and Determination of its Antibacterial Activity

Al-Zayadi,

Shanan,

Salihi

2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…[51] Fur-thermore, its curative effects on acute oral toxicity and myocardial infarction were investigated in vivo. [22,23] Although S. lappa has been used to treat bronchitis since many years, its effect on upper respiratory tract infections caused by coronaviruses was studied for the first time using in vitro and in vivo studies. In our study, we discovered that using S. lappa aqueous extract on a regular basis during the COVID-19 disease protects and heals animals.…”

Section: Discussionmentioning

confidence: 99%

“…At the end of 7 days, gross pathology showed no signs of toxicity or death. [22,33] In the challenge experiment, mice were given 100 mg kg −1 body weight of S. lappa extract orally once a day. [24,33]…”

Section: Determination Of S Lappa Dosagementioning

confidence: 99%

Investigation of the Antiviral Effects of Saussurea lappa Root Extract against SARS‐CoV‐2 Virus

Ulbegi Polat,

Serhatli,

Taş Ekiz

et al. 2023

Molecular Nutrition Food Res

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Scope The purpose of this study was to look into the antiviral activity of a plant extract derived from the roots of the Saussurea lappa as a food supplement against SARS‐CoV‐2 infection. Methods and results Vero E6 cells are employed in the study to test the neutralizing effect of Saussurea lappa extract against the SARS‐CoV‐2 virus. For anti‐viral activity detection, a sensitive real‐time cell analyzer (xCELLigence RTCA) with a high repetition rate is used. A challenge experiment in mice is planned as a result of the in vitro analysis. A challenge test against SARS‐CoV‐2 is performed with 10 adult female K18‐hACE2 transgenic mice in each group for this purpose. The mice in the S. lappa Group are gavaged 2 days before the virus is administered intranasally (i.n.). The control group received PBS instead of the extract. SARS‐CoV‐2 virus is administered i.n. under anesthesia for the first 3 days of the experiment, and S. lappa extract was administered by gavage in the afternoon. On the 10th day, mice in the S. lappa group survived the study, whereas animals in the control group grew ill and/or died. In this study, the extract protects the mice against the SARS‐CoV‐2 virus in 90% of the cases. Conclusions This study demonstrates that the Saussurea plant has antiviral effects against SARS‐CoV‐2 in vitro and in animal models.

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“…For example, but not limited to medical compounds, can inhibit the growth of different pathogenic microbes and can also suppress the growth of different types of cancer cells [ 2 ]. Furthermore, herb extracts possess antioxidant properties that play an important role in reducing oxidative stress [ 3 ]. Herbs and their extracts are considered safe for usage not only in the pharmaceutical sector but are extended to include cosmetics, food additives, and nutrition sectors [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nowadays, nearly 85,000 medicinal plant species are used throughout the world. However, much more of these plants with innumerable phytochemicals are unstudied entirely; among such medicinal plants is Sausurea costus , which belongs to the Asteraceae family [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Supercritical Carbon Dioxide Extraction of Saussurea costus Oil and Its Antimicrobial, Antioxidant, and Anticancer Activities

et al. 2022

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Saussurea costus is a medicinal plant with different bioactive compounds that have an essential role in biomedicine applications, especially in Arab nations. However, traditional extraction methods for oils can lead to the loss of some volatile and non-volatile oils. Therefore, this study aimed to optimize the supercritical fluid extraction (SFE) of oils from S. costus at pressures (10, 20, and 48 MPa). The results were investigated by GC/MS analysis. MTT, DPPH, and agar diffusion methods assessed the extracted oils’ anticancer, antioxidant, and antimicrobial action. GC/MS results showed that elevated pressure from 10 to 20 and 48 MPa led to the loss of some valuable compounds. In addition, the best IC50 values were recorded at 10 MPa on HCT, MCF-7, and HepG-2 cells at about 0.44, 0.46, and 0.74 μg/mL, respectively. In contrast, at 20 MPa, the IC50 values were about 2.33, 6.59, and 19.0 μg/mL, respectively, on HCT, MCF-7, and HepG-2 cells, followed by 48 MPa, about 36.02, 59.5, and 96.9 μg/mL. The oil extract at a pressure of 10 MPa contained much more of á-elemene, dihydro-à-ionone, patchoulene, á-maaliene, à-selinene, (-)-spathulenol, cedran-diol, 8S,13, elemol, eremanthin, á-guaiene, eudesmol, ç-gurjunenepoxide-(2), iso-velleral, and propanedioic acid and had a higher antioxidant activity (IC50 14.4 μg/mL) more than the oil extract at 20 and 48 MPa. In addition, the inhibitory activity of all extracts was higher than gentamicin against all tested bacteria. One of the more significant findings from this study is low pressure in SFE enhancement, the extraction of oils from S. costus, for the first time. As a result, the SFE is regarded as a good extraction technique since it is both quick and ecologically friendly. Furthermore, SFE at 10 MPa increased the production and quality of oils, with high antioxidant activity and a positive effect on cancer cells and pathogens.

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Root extracts of Saussurea costus as prospective detoxifying food additive against sodium nitrite toxicity in male rats

Cited by 18 publications

References 45 publications

Extraction and Evaluation of Active Ingredients of Saussurea costus Roots and Determination of its Antibacterial Activity

Extraction and Evaluation of Active Ingredients of Saussurea costus Roots and Determination of its Antibacterial Activity

Investigation of the Antiviral Effects of Saussurea lappa Root Extract against SARS‐CoV‐2 Virus

Optimization of Supercritical Carbon Dioxide Extraction of Saussurea costus Oil and Its Antimicrobial, Antioxidant, and Anticancer Activities

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