Adverse effects of nanosilver on human health and the environment

Rezvani, Ehsan; Rafferty, Aran; McGuinness, Cormac; Kennedy, James E.

doi:10.1016/j.actbio.2019.05.042

Cited by 147 publications

(102 citation statements)

References 124 publications

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“…Therefore, the combination of graphene and AgNPs based nanocomposites has been widely produced to enhanced antibacterial and anticancer activity [35]. The AgNPs can easily enter cells, thus affect the physiology of organisms, which may have the potential toxicity both on human and animal health or ecosystems [26]. Therefore, the adverse effects of GO-AgNPs composites have been considered as a major limitation for its broad applications.…”

Section: Discussionmentioning

confidence: 99%

“…Humans could be directly exposed to AgNPs of many consumer products via the route of inhalation, dermal contact and oral ingestion [26]. Therefore, toxical effect of these products is required to ensure that they are safe to use.…”

Section: Discussionmentioning

confidence: 99%

“…spleen [24][25][26]. In addition to the dependence of toxicity on surface functionalization, graphene, GO and reduced GO differentially induced toxicity is especially dependent on their sizes and oxidation state as well as the exposure concentrations and sensitivity of the employed in vitro and in vivo models [27,28].…”

mentioning

confidence: 99%

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Graphene oxide-silver nanocomposites induce oxidative stress and apoptosis in caprine fetal fibroblast cells

Yuan¹,

Joo²,

Wang³

et al. 2020

Preprint

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Background: Graphene oxide (GO) has drawn much attention as excellent platform to which silver nanoparticles (AgNPs) can be anchored for the production of biomedical nanocomposites. Yet, the potential toxicity of reduced graphene oxide- silver nanoparticles (GO-AgNPs) nanocomposites to animal and human is complex to evaluate and remains largely unknown.Results: Our data indicated that GO-AgNPs caused cytotoxicity in dose-dependent manner. GO-AgNPs induced significant cytotoxicity by the loss of cell viability, over-production of reactive oxygen species (ROS), increased leakage of lactate dehydrogenase (LDH) and level of malondialdehyde (MDA), increased expression of pro-apoptotic genes and decreased expression of anti-apoptotic genes.Conclusions: This study demonstrated that GO-AgNPs potentially induced oxidative stress, which resulted in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. For antibacterial applications of GO-AgNPs nanocomposite in animal, the toxical effect must be further evaluated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Graphene oxide-silver nanocomposites induce oxidative stress and apoptosis in caprine fetal fibroblast cells

Yuan¹,

Joo²,

Wang³

et al. 2020

Preprint

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“…However, more information is needed about the toxicity of the conductive inks used in the neural regeneration system, including threshold limits, safe doses, and biocompatibility. For instance, although nanoscale silver particles are now in widespread use in a variety of commercial products, these particles can cause neurotoxicity, reduced neurite outgrowth, inflammation and oxidative stress . Alternative approaches using noncontact stimuli such as light, magnetic fields, or ultrasound could be promising alternatives for neural stimulation devices …”

Section: Summary Technical Challenges and Outlookmentioning

confidence: 99%

3D Printed Neural Regeneration Devices

Joung

Lavoie

Guo

et al. 2019

Adv Funct Materials

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Neural regeneration devices interface with the nervous system and can provide flexibility in material choice, implantation without the need for additional surgeries, and the ability to serve as guides augmented with physical, biological (e.g., cellular), and biochemical functionalities. Given the complexity and challenges associated with neural regeneration, a 3D printing approach to the design and manufacturing of neural devices can provide next-generation opportunities for advanced neural regeneration via the production of anatomically accurate geometries, spatial distributions of cellular components, and incorporation of therapeutic biomolecules. A 3D printing-based approach offers compatibility with 3D scanning, computer modeling, choice of input material, and increasing control over hierarchical integration. Therefore, a 3D printed implantable platform can ultimately be used to prepare novel biomimetic scaffolds and model complex tissue architectures for clinical implants in order to treat neurological diseases and injuries. Further, the flexibility and specificity offered by 3D printed in vitro platforms have the potential to be a significant foundational breakthrough with broad research implications in cell signaling and drug screening for personalized healthcare. This progress report examines recent advances in 3D printing strategies for neural regeneration as well as insight into how these approaches can be improved in future studies.spinal cord, and the peripheral nervous system (PNS), composed of the cranial and spinal nerves along with their associated ganglia that connect the CNS to the body. These systems are interconnected via an extensive network of nerves and neural cells (i.e., neurons and supporting glial cells) to facilitate communication and relay information (sensorimotor signals) to and from all parts of the body.

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“…Stoehr et al compared the cytotoxicity of AgNWs (length: 1.5-25 µm; diameter 100-160 nm) and Ag nanospheres (30 nm) against human alveolar epithelial cells (A549), finding that whereas no effects were observed for the spherical particles, significantly reduced cell viability and increased LDH release were induced by AgNWs [15]. A recent review on the safety of nanosilver has highlighted that, at the nanoscale, silver nanowires are safer than silver nanoparticles due to their hindered cellular uptake [16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications

Mori

Jones

Cretella

et al. 2020

IJMS

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In this work, we prepared silver nanowires (AgNWs) via the polyol method in the presence or absence of single wall carbon nanotubes (CNTs) and tested their physicochemical, antibacterial and cytotoxic properties. Results showed that the introduction of CNTs lead to the formation of AgNWs at lower temperature, but the final product characteristics of AgNWs and AgNWs-CNT were not significantly different. AgNWs exhibited antibacterial properties against all the studied bacterial species via the formation of oxygen reactive species (ROS) and membrane damage. Furthermore, AgNWs exhibited a dose-dependent and time-dependent toxicity at concentrations ≥ 10 µg/mL. Fibroblasts appeared to be more resistant than human colorectal adenocarcinoma (Caco-2) and osteoblasts to the toxicity of AgNWs. The cytotoxicity of AgNWs was found to be related to the formation of ROS, but not to membrane damage. Overall, these results suggest that AgNWs are potential antibacterial agents against E. coli, S. aureus, MRSA and S. saprophyticus, but their dosage needs to be adjusted according to the route of administration.

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Adverse effects of nanosilver on human health and the environment

Cited by 147 publications

References 124 publications

Graphene oxide-silver nanocomposites induce oxidative stress and apoptosis in caprine fetal fibroblast cells

Graphene oxide-silver nanocomposites induce oxidative stress and apoptosis in caprine fetal fibroblast cells

3D Printed Neural Regeneration Devices

Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications

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