Adverse Effects of Organophosphorus Insecticides on Macrophage Activity in Persons at High Risk for Parasitic Infection

Ashour, Magdy N.; Mohamed, Mohamed Essa; Elsawy, Bassem Mohamed

doi:10.3889/mjms.1857-5773.2011.0143

Cited by 3 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and delayed the healing of cutaneous leishmaniasis lesions due to alterations in the immune response. This immunotoxicity could be associated with a significant increase in the level of the anti-inflammatory mediator arginase coupled with a significant decrease in the levels of the proinflammatory mediators NO and IFN-γ, as previously reported 18 .…”

Section: Discussionsupporting

confidence: 76%

“…Some epidemiological studies report that exposure to OP pesticides may increase the rate and risk of infections in rural populations 16 , exacerbating cutaneous leishmaniasis and inducing a low response to treatment in farmers exposed to chlorpyrifos, an OP pesticide that generates DETP and DEP 17 . In vivo studies showed that these effects on the immune response may be due to a decrease in the levels of plasma nitric oxide (NO) and interferon (IFN)-γ and to the increase in the activity of arginase, which explains the inability of macrophages (MΦ) to control the parasites or induce an adequate immune response against them 18 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure

Medina-Buelvas

Estrada-Muñiz

Rodrı́guez-Sosa

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Some reports suggest that exposure to organophosphorus (OP) pesticides increases the incidence of infections. Ethylated dialkylphosphates (EtDAPs) are metabolites of OP pesticides widely distributed with immunomodulatory potential. Chagas disease is produced by Trypanosoma cruzi parasites, and resolution of this infection requires the activation of inflammatory macrophages (MΦ), which results in cardiac fibrosis. Some reports indicate that EtDAPs increase the amount of the anti-inflammatory alternatively activated MΦ (M2; CD206+F4/80+). Therefore, we analyzed the course of T. cruzi infection, MΦ profiles from peritoneal exudate cells (PECs), inflammatory cell infiltration and fibrosis in the heart of BALB/c mice exposed to diethyldithiophosphate (DEDTP), diethylthiophosphate (DETP) or diethylphosphate (DEP, 0.01 g/kg), common DAPs produced by OP pesticides, 24 h before infection with T. cruzi. We found that DEDTP increased the parasite burden in blood by 99% at the peak of the infection and enhanced the myocardial damage due to an increase in infiltrated inflammatory cells (induced by DEDTP or DETP) and fibrosis (induced by EtDAPs). In the PECs, exposure to EtDAPs increased the proportion of the MΦ subpopulations of M2a, M2b and M2d, which are associated with tissue repair. These results indicate that exposure to EtDAPs can exacerbate the acute phase of a parasitic infection and increase the long-term damage to the heart.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Increased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure

Medina-Buelvas

Estrada-Muñiz

Rodrı́guez-Sosa

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

Curcumin Combats against Organophosphate Pesticides Toxicity: A Review of the Current Evidence and Molecular Pathways

Jafari-Nozad

Jafari

Aschner

et al. 2023

CMC

View full text Add to dashboard Cite

Organophosphate compounds are regarded as a class of pesticides that are used in farming. Their extensive use, especially in developing countries, is a serious public health problem. Numerous studies have shown the effects of these toxins on various parts of the human and other vertebrates’ bodies, including the cardiovascular, hepatobiliary, renal, and reproductive systems. Curcumin is a polyphenol compound obtained from the rhizome of the Curcuma longa. Curcumin has been known as a dietary spice, food additive, and traditional medicine since many years ago. In recent decades, the medicinal characteristics, clinical aspects, and biological activity of Curcumin have been extensively examined. The most examined positive characteristics of Curcumin are its anti-inflammatory and anti-oxidant qualities. This review will deal with the pharmacological properties of Curcumin as well as an update of currently available studies in terms of Curcumin’s uses and function against organophosphate pesticides-induced toxicity on different human organs.

show abstract

A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences

Mokarizadeh

Faryabi

Rezvanfar

et al. 2015

Toxicology Mechanisms and Methods

143

View full text Add to dashboard Cite

Nowadays, in many communities, there is a growing concern about possible adverse effects of pesticides on human health. Reports indicate that during environmental or occupational exposure, pesticides can exert some intense adverse effects on human health through transient or permanent alteration of the immune system. There is evidence on the relation between pesticide-induced immune alteration and prevalence of diseases associated with alterations of the immune response. In the present study, direct immunotoxicity, endocrine disruption and antigenicity have been introduced as the main mechanisms working with pesticides-induced immune dysregulation. Moreover, the evidence on the relationship between pesticide exposure, dysregulation of the immune system and predisposition to different types of psychiatric disorders, cancers, allergies, autoimmune and infectious diseases are criticized.

show abstract

Adverse Effects of Organophosphorus Insecticides on Macrophage Activity in Persons at High Risk for Parasitic Infection

Abstract: Background: It has been suggested that acute exposure to pesticides altered the ability of macrophages to overcome the pathogen invasion.

Cited by 3 publications

References 23 publications

Increased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure

Increased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure

Curcumin Combats against Organophosphate Pesticides Toxicity: A Review of the Current Evidence and Molecular Pathways

A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences

Contact Info

Product

Resources

About