Adverse Effects of Red-Cell Transfusion

Ness, Paul M.; Triulzi, Darrell J.; Carson, Jeffrey L.

doi:10.1056/nejmc1714159

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…Among the outcome variables associated with achieving a TO, no prolonged hospital stay and no perioperative blood transfusion had lower proportions, consistent with previous findings. [9,10,17] Although blood transfusion can cause immunosuppression and affect the long and short term prognosis of patients, the adverse effect on intraoperative blood loss is more important than that of blood transfusion on the prognosis of patients [23][24][25] Therefore, delicate surgical operations can effectively reduce blood loss and prevent blood transfusions by reducing intraoperative bleeding and coagulation disorders. Furthermore, shortening hospital stay during perioperative surgery and care should be a priority to help GBC patients achieve a TO.…”

Section: Discussionmentioning

confidence: 99%

Textbook outcome in gallbladder carcinoma after curative-intent resection: a 10-year retrospective single-center study

Liu

Gao

et al. 2023

Chinese Medical Journal

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Background: Textbook outcome (TO) can guide decision-making among patients and clinicians during preoperative patient selection and postoperative quality improvement. We explored the factors associated with achieving a TO for gallbladder carcinoma (GBC) after curative-intent resection and analyzed the effect of adjuvant chemotherapy (ACT) on TO and non-TO patients. Methods: A total of 540 patients who underwent curative-intent resection for GBC at the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Xi'an Jiaotong University from January 2011 to December 2020 were retrospectively analyzed. Multivariable logistic regression was used to investigate the factors associated with TO. Results: Among 540 patients with GBC who underwent curative-intent resection, 223 patients (41.3%) achieved a TO. The incidence of TO ranged from 19.0% to 51.0% across the study period, with a slightly increasing trend over the study period. The multivariate analysis showed that non-TO was an independent risk factor for prognosis among GBC patients after resection (P = 0.003). Age ≤60 years (P = 0.016), total bilirubin (TBIL) level ≤34.1 μmol/L (P <0.001), well-differentiated tumor (P = 0.008), no liver involvement (P <0.001), and T1–2 stage disease (P = 0.006) were independently associated with achieving a TO for GBC after resection. Before and after propensity score matching (PSM), the overall survival outcomes of non-TO GBC patients who received ACT and those who did not were statistically significant; ACT improved the prognosis of patients in the non-TO group (P <0.05). Conclusion: Achieving a TO is associated with a better long-term prognosis among GBC patients after curative-intent resection, and ACT can improve the prognosis of those with non-TO.

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