Adverse events and safety issues in blood donation—A comprehensive review

A review of the haematopoietic stem cell donation experience: is there room for improvement?

“…7,9 Furthermore, a positive correlation between younger donors and increased pre-syncopal and syncopal events as demonstrated in whole blood donors, has not been established in PBSC donation. 50,55,56 This finding is surprising, given that the extracorporeal blood volume can exceed 20% of the donor's blood volume during apheresis 57 and most apheresis machines do not routinely provide saline infusions. Conversely, older PBSC donors were more likely to experience citrate-related toxicity and persistent toxicities at 1 week, 7,50 reflecting a slower recovery period than younger donors for all aspects of the donation process.…”

Prevalence and determinants of declining versus stable hemoglobin levels in whole blood donors

“…Blood donation causes a loss of iron and blood cells, which can lead to depleted iron stores and lowering of Hb levels. 29 Potential symptoms of iron deficiency include fatigue, decreased physical endurance and work capacity, and impairment in attention, concentration, and other cognitive functions. 2,[30][31][32][33] Restless legs syndrome, a neurologic disorder with irresistible need to move the legs, and pica, a disorder in which a person is craving and consuming nonnutritive substances, have also been repeatedly linked to blood donation-related iron deficiency.…”

Deferrals of volunteer stem cell donors referred for evaluation for matched-unrelated stem cell donation

“…Even with careful donor evaluation, a serious adverse event frequency of 0.11-0.6% for PBSC and 0.043-1.34% for BM donation is reported, compared with a serious adverse event frequency of 0.005% for whole blood donation. 5,8,[14][15][16] The relative uniqueness of certain HLA combinations implies that the directed donation from a designated stem cell donor may be a recipient's only chance of survival. Suitably matched mature blood cell components, on the other hand, are generally available in ample quantities.…”