Adverse Events in Pediatric Patients Receiving Long-term Oral and Intravenous Antibiotics

Murphy, Jennifer L.; Fenn, Norman E.; Pyle, Laura; Heizer, Heather; Hughes, Shannon; Nomura, Yoshihiko; Child, Jason; Parker, Sarah K.

doi:10.1542/hpeds.2015-0069

Cited by 25 publications

(12 citation statements)

References 32 publications

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“…Our overall rate of treatment complications was lower and likely reflects the lower complication rate seen with oral regimens. Our findings are similar to those of recent studies in children that reported treatment-related complications of PO and IV therapy for other infectious diseases; increasing numbers of studies are concluding that when oral options exist for the completion of antibiotic therapy, they should be used [9,11,12].…”

Section: Discussionsupporting

confidence: 90%

Treatment-Related Complications in Children Hospitalized With Disseminated Lyme Disease

Chang

Feemster

Coffin

et al. 2017

Journal of the Pediatric Infectious Diseases Society

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We describe here treatment approaches and treatment-related complications in 138 hospitalized children with disseminated Lyme disease. The patients who received parenteral antibiotics had a higher rate of complications than those who received oral therapy (15.4 vs 4.2 per 1000 days of therapy, respectively; P < .05). Oral therapy should be used preferentially if either route is supported by current guidelines.

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Section: Discussionsupporting

confidence: 90%

Treatment-Related Complications in Children Hospitalized With Disseminated Lyme Disease

Chang

Feemster

Coffin

et al. 2017

Journal of the Pediatric Infectious Diseases Society

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“…Antibiotics, particularly beta‐lactams, were the most frequent cause. Another recent study showed similar findings (Murphy et al , ). Children and adults are at risk of chemotherapy‐associated neutropenia.…”

Section: Drug‐and Chemotherapy‐associated Neutropenia In Childrensupporting

confidence: 79%

How I manage children with neutropenia

Dale

2017

Br J Haematol

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Neutropenia, usually defined as a blood neutrophil count <1·5 × 10 /l, is a common medical problem for children and adults. There are many causes for neutropenia, and at each stage in life the clinical pattern of causes and consequences differs significantly. I recommend utilizing the age of the child and clinical observations for the preliminary diagnosis and primary management. In premature infants, neutropenia is quite common and contributes to the risk of sepsis with necrotizing enterocolitis. At birth and for the first few months of life, neutropenia is often attributable to isoimmune or alloimmune mechanisms and predisposes to the risk of severe bacterial infections. Thereafter when a child is discovered to have neutropenia, often associated with relatively minor symptoms, it is usually attributed to autoimmune disorder or viral infection. The congenital neutropenia syndromes are usually recognized when there are recurrent infections, the neutropenia is severe and there are congenital anomalies suggesting a genetic disorder. This review focuses on the key clinical finding and laboratory tests for diagnosis with commentaries on treatment, particularly the use of granulocyte colony-stimulating factor to treat childhood neutropenia.

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“…The incidence of treatment-induced neutropenia is estimated around 4 cases per 10,000 hospitalized patients [79]. Among the undesirable effects, regardless of the route of administration (oral or parenteral), the incidence of neutropenia is 6% [80]. One of the most common causes of neutropenia is the use of antibiotic therapy, particularly betalactams, sulfamethoxazole with trimethoprim and vancomycin [81].…”

Section: Antibiotic-induced Neutropeniamentioning

confidence: 99%