Adverse Reactions due to Indocyanine Green

Hope–Ross, M.; Yannuzzi, Lawrence A.; Gragoudas, Evangelos S.; Guyer, David R.; Slakter, Jason S.; Sorenson, John A.; Krupsky, Sara; Orlock, Dennis A.; Puliafito, Carmen A.

doi:10.1016/s0161-6420(94)31303-0

Cited by 567 publications

(300 citation statements)

References 16 publications

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“…It is well tolerated, causing only mild side effects such as nausea and skin rash in 0–10% of cases. Deaths, amounting to 1 in 333,333 cases, have mainly been due to anaphylactic reactions [38]. …”

Section: Methodsmentioning

confidence: 99%

Clinical Application of Digital Indocyanine Green Angiography in Choroidal Neurofibromatosis

Rescaldani¹,

Nicolini²,

Fatigati³

et al. 1998

Ophthalmologica

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Indocyanine green angiography (ICGA) was used to investigate 2 cases of type 1 systemic neurofibromatosis that had appeared at birth with café-au-lait skin spots, gradually developing into multiple cutaneous neurofibromas. Patients underwent periodical visual acuity examinations, the fundus was checked and fluorescein angiography (FA) was done; all findings appeared extremely stable. In 1995 these 2 patients underwent ICGA to check for pathological choroidal involvement. In both cases the initial examination stages showed multiple extensive areas of hypofluorescence, their morphology and extension coinciding with the retinal pigment epithelium (RPE) lesions shown by FA and by ophthalmoscopic examination. In later stages the hypofluorescent areas became smaller, generally shrinking to small isolated dots in the middle of the original areas. These initially hypofluorescent areas appeared to be due to slow focal choroidal filling caused by deep alterations to the walls of the choroidal arterioles induced by the disease. Chronic hypoperfusion of the choriocapillaris results in impairment of the overlying RPE, causing it to atrophy. The late hypofluorescent areas could be either persistent nonperfused lobules of choriocapillaris or neurofibromatose choroidal nodules. ICGA examination showed that the FA lesions described in the literature as choroidal nodules are in fact alterations to the RPE secondary to areas of hypoperfusion in the choriocapillaris.

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Section: Methodsmentioning

confidence: 99%

Clinical Application of Digital Indocyanine Green Angiography in Choroidal Neurofibromatosis

Rescaldani¹,

Nicolini²,

Fatigati³

et al. 1998

Ophthalmologica

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“…After precipitation with ethyl ether, these dyes were obtained as deep blue solids. Final purification was performed by dialysis against water and the materials were characterized by 1 H and 13 C NMR spectroscopy and mass spectrometry (see the Supporting Information).…”

Section: Wwwchemeurjorgmentioning

confidence: 99%

“…[8] It is considered a safe imaging agent and has been used in tens of thousands of patients with a reported side-effect rate below 0.15 %, an extremely favorable index when compared to other imaging agents. [8,[11][12][13] This impressive biocompatibility has initiated a search for cyanine dye derivatives containing functional handles available for further functionalization in order to attach these dyes to peptides, targeting groups and/or drug carriers. [10] Unfortunately, the synthesis of ICG derivatives is often difficult and low yielding mainly due to low solubility and chemical stability.…”

Section: Introductionmentioning

confidence: 99%

Combining Aminocyanine Dyes with Polyamide Dendrons: A Promising Strategy for Imaging in the Near‐Infrared Region

Ornelas

Lodescar

Durandin

et al. 2011

Chemistry A European J

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Cyanine dyes are known for their fluorescence in the near-IR (NIR) region, which is desirable for biological applications. We report the synthesis of a series of aminocyanine dyes containing terminal functional groups such as acid, azide, and cyclooctyne groups for further functionalization through, for example, click chemistry. These aminocyanine dyes can be attached to polyfunctional dendrons by copper-catalyzed azide alkyne cycloaddition (CuAAC), strain-promoted azide alkyne cycloaddition (SPAAC), peptide coupling, or direct S(NR)1 reactions. The resulting dendron-dye conjugates were obtained in high yields and displayed high chemical stability and photostability. The optical properties of the new compounds were studied by UV/Vis and fluorescence spectroscopy. All compounds show large Stokes shifts and strong fluorescence in the NIR region with high quantum yields, which are optimal properties for in vivo optical imaging.

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“…Although no equivalent data exists for humans, the maximum recommended human dose is 5 mg kg À1 . The safety of intravenous ICG in humans is well documented, with severe adverse reactions occurring in only 0.05% of recipients [172]. 11.5.3.6 Tumor Imaging with ICG ICG is rapidly gaining acceptance as a diagnostic agent for tumor imaging purposes due to its NIR fluorescence characteristics.…”

Section: Binding Properties Of Icgmentioning

confidence: 99%

Biocompatible Nanoparticulate Systems for Tumor Diagnosis and Therapy

Sadoqi

Kumar

Lau‐Cam

et al. 2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Nanoscale Particulate Systems and their Building Blocks/Components Dendrimers Buckyballs and Buckytubes Quantum Dots Polymeric Micelles Liposomes Biodegradable Nanoparticles Preparation of Nanoparticles Biodegradable Optical Nanoparticles Optical Nanoparticles as a Potential Technology for Tumor Diagnosis Optical Nanoparticles as a Potential Technology for Tumor Treatment Optical Imaging and PDT Optical Imaging Fluorescence‐based Optical Imaging NIR Fluorescence Imaging NIR Dyes for Fluorescence Imaging PDT Basis of PDT Photosensitizers for PDT ICG : An Ideal Photoactive Agent for Tumor Diagnosis and Treatment Clinical Uses of ICG Structure and Physicochemical Properties of ICG Binding Properties of ICG Metabolism, Excretion and Pharmacokinetics of ICG Toxicity of ICG Tumor Imaging with ICG PDT with ICG Limitations of ICG for Tumor Diagnosis and Treatment Recent Approaches for Improving the Blood Circulation Time and Uptake of ICG by Tumors Recent Approaches for ICG Stabilization In Vitro PLGA ‐based Nanoparticulate Delivery System for ICG Rationale of Using a PLGA ‐based Nanoparticulate Delivery System for ICG In Vivo Pharmacokinetics of ICG Solutions and Nanoparticles Conclusions and Future Work

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Adverse Reactions due to Indocyanine Green

Cited by 567 publications

References 16 publications

Clinical Application of Digital Indocyanine Green Angiography in Choroidal Neurofibromatosis

Clinical Application of Digital Indocyanine Green Angiography in Choroidal Neurofibromatosis

Combining Aminocyanine Dyes with Polyamide Dendrons: A Promising Strategy for Imaging in the Near‐Infrared Region

Biocompatible Nanoparticulate Systems for Tumor Diagnosis and Therapy

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